Monitoring of atopic dermatitis using leaky coaxial cable

In our daily life, inadvertent scratching may increase the severity of skin diseases (such as atopic dermatitis, etc.). However, people rarely pay attention to this matter, so the known measurement behavior of the movement is also very little. Nevertheless, the behavior and frequency of scratching represent the degree of itching, and the analysis of scratching frequency is helpful to the doctor's clinical dosage. In this paper, a novel system is proposed to monitor the scratching motion of a sleeping human body at night. The core device of the system are just a Leaky coaxial cable (LCX) and a router. Commonly, LCX is used in the blind field or semi blind field in wireless communication. The new idea is that the leaky cable is placed on the bed, then the state information of physical layer of wireless communication channels is acquired to identify the scratching motion and other small body movements in the human sleep process. The results show that it can be used to detect the movement and its duration. Channel state information (CSI) packet is collected by card installed in the computer based on the 802.11n protocol. The characterization of the scratch motion in the collected channel state information is unique, so it can be distinguished from the wireless channel amplitude variation trend

Scratching the Bose surface

This is a `News and Views' article discussing recent proposals for ground states of many boson systems which are neither superfluids nor Mott insulators.Comment: 4 pages, 1 figur

Brain processing of contagious itch in patients with atopic dermatitis

Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined Contagious itch (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that AD-patients could profit from when they are confronted with itch-inducing situations in daily life. Therefore, this study investigated the brain processing of CI in AD-patients. 11 AD-patients underwent fMRI scans during the presentation of an itch inducing experimental video (EV) and a non-itch inducing control video (CV). Perfusion based brain activity was measured using arterial spin labeling functional MRI. As expected, the EV compared to the CV led to an increase in itch and scratching (p \u3c 0.05). CI led to a significant increase in brain activity in the supplementary motor area, left ventral striatum and right orbitofrontal cortex (threshold: p \u3c 0.001; cluster size k \u3e 50). Moreover, itch induced by watching the EV was by trend correlated with activity in memory-related regions including the temporal cortex and the (pre-) cuneus as well as the posterior operculum, a brain region involved in itch processing (threshold: p \u3c 0.005; cluster size k \u3e 50). These findings suggest that the fronto-striatal circuit, which is associated with the desire to scratch, might be a target region for non-invasive treatments in AD patients. © 2017 Schut, Mochizuki, Grossman, Lin, Conklin, Mohamed, Gieler, Kupfer and Yosipovitch

Pad Scratching in Chemical-Mechanical Polishing: The Effects of Mechanical and Tribological Properties

In chemical-mechanical polishing (CMP), even the soft pad asperities may, under certain conditions, generate scratches on the relatively hard surfaces being polished. In the present study, contact mechanics models of pad-induced scratching are formulated, and the effects of the hardness of the surface layers and of pad asperities as well as the interfacial friction are elucidated. Additionally, scratch-regime maps are proposed to provide criteria for scratching hard surface layers by the softer pad asperities. Furthermore, scratching indexes are introduced to predict the proportion of asperities in contact that are likely to scratch. The contact mechanics models of scratching have been validated by sliding experiments with two commercial CMP pads (Pad A and IC1000) and various thin-films (Al, Cu, SiO[subscript 2], Si[subscript 3]N[subscript 4], TiN and three low-k dielectrics) using deionized water as a “lubricant.” Both the theoretical models and the experimental results show that the number of scratches increases as the scratching index exceeds 0.33. Al and Cu layers are found to be more susceptible to pad scratching due to their low hardness and high interfacial friction. The scratch-regime maps provide practical guidelines for mitigating pad scratching in CMP.Samsung (Firm

The Role of Ethological Observation for Measuring Animal Reactions to Biotelemetry Devices

This paper presents a methodological approach used to assess the wearability of biotelemetry devices in animals. A detailed protocol to gather quantitative and qualitative ethological observations was adapted and tested in an experimental study of 13 cat participants wearing two different GPS devices. The aim was twofold: firstly, to ascertain the potential interference generated by the devices on the animal body and behavior by quantifying and characterizing it; secondly, to individuate device features potentially responsible for the influence registered, and establish design requirements. This research contributes towards the development of a framework for evaluating the design of wearer-centered biotelemetry interventions for animals, consistent with values advocated by Animal- Computer Interaction researchers

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.

Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the development of itch and the acute-to-chronic itch transition remain unknown. Here, we show that skin-infiltrating neutrophils are key initiators of itch in atopic dermatitis, the most prevalent chronic itch disorder. Neutrophil depletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis. Neutrophils were also required for several key hallmarks of chronic itch, including skin hyperinnervation, enhanced expression of itch signaling molecules, and upregulation of inflammatory cytokines, activity-induced genes, and markers of neuropathic itch. Finally, we demonstrate that neutrophils are required for induction of CXCL10, a ligand of the CXCR3 receptor that promotes itch via activation of sensory neurons, and we find that that CXCR3 antagonism attenuates chronic itch

MgB2 radio-frequency superconducting quantum interference device prepared by atomic force microscope lithography

A new method of preparation of radio-frequency superconducting quantum interference devices on MgB2 thin films is presented. The variable-thickness bridge was prepared by a combination of optical lithography and of the scratching by an atomic force microscope. The critical current of the nanobridge was 0.35 uA at 4.2 K. Non-contact measurements of the current-phase characteristics and of the critical current vs. temperature have been investigated on our structures.Comment: RevTeX4. Accepted in Appl. Phys. Let