Pengaruh Rasio Camel Dan Corporate Governance Terhadap Praktik Manajemen Laba Di Bank Syariah

Tujuan dari Penelitian ini adalah untuk mengetahui pengaruh Rasio CAMEL dan Corporate governance terhadap manajemen laba di Bank Syariah. Rasio CAMEL diukur menggunakan Rasio CAR, RORA, ROA, NPM dan LDR, sedangkan corporate governance diukur dengan komposisi dewan komisaris, ukuran dewan komisaris, keberadaan komite audit dan dewan pengawas syariah. Data yang digunakan adalah data dari annual report yang dipublikasi di website masing-masing sampel bank syariah dari tahun 2010-2011. Metode penelitian yang dilakukan merupakan penelitian yang bersifat deskriptif kuantitatif dengan uji regresi berganda. Berdasarkan hasil penelitian pada model regresi diketahui bahwa variabel LDR dan KKA yang berpengaruh signifikan terhadap DAit (manajemen laba). 34,9% (uji dengan variabel RORA) dan 35% (uji dengan variabel ROA) artinya bahwa keragaman dari variabel dependen mampu diterangkan sebesar prosentase tersebut dan sisanya sebesar 65,1% (uji dengan variabel RORA) dan 65% (uji dengan variabel ROA) dijelaskan oleh faktor-faktor lain di luar model. Sedangkan variabel CAR, RORA, ROA, NPM, KDK, UDK dan DPS tidak berpengaruh signifikan terhadap DAit (manajemen laba)

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain

Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic analyses to localize individual genes acting pleiotropically upon these phenotypes. Methods: Whole-brain and regional GM thickness and FA values were measured from high-resolution anatomical and diffusion tensor MR images collected from 712, Mexican American participants (438 females, age=47.9±13.2 years) recruited from 73 (9.7±9.3 individuals/family) large families. The significance of the correlation between two traits was estimated using a bivariate genetic correlation analysis. Localization of chromosomal regions that jointly influenced both traits was performed using whole-genome quantitative trait loci (QTL) analysis. Gene localization was performed using SNP genotyping on Illumina 1M chip and correlation with leukocyte-based gene-expression analyses. The gene-expressions were measured using the Illumina BeadChip. These data were available for 371 subjects. Results: Significant genetic correlationwas observed amongGMthickness and FA values. Significant logarithm of odds (LOD≥3.0) QTLs were localized within chromosome 15q22–23. More detailed localization reported no significant association (p <5·10−5) for 1565 SNPs located within the QTLs. Post hoc analysis indicated that 40% of the potentially significant (p ≤10−3) SNPs were localized to the related orphan receptor alpha (RORA) and NARG2 genes. A potentially significant association was observed for the rs2456930 polymorphism reported as a significant GWAS finding in Alzheimer’s disease neuroimaging initiative subjects. The expression levels for RORA and ADAM10 genes were significantly (p <0.05) correlated with both FA and GM thickness. NARG2 expressions were significantly correlated with GM thickness (p <0.05) but failed to show a significant correlation (p =0.09) with FA. Discussion: This study identified a novel, significant QTL at 15q22–23. SNP correlation with gene-expression analyses indicated that RORA, NARG2, and ADAM10 jointly influenceGM thickness and WM–FA values

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis

BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis of patients with soft tissue sarcoma. PATIENTS AND METHODS: We considered the 14 single nucleotide polymorphisms (SNPs) of 6 core circadian genes that have a minor allele frequency >\u20095% and that are known to be associated with cancer risk or prognosis. Genotyping was performed by q-PCR. Peripheral blood and clinic-pathological data were available for 162 patients with liposarcoma or leiomyosarcoma and 610 healthy donors. Associations between the selected clock genes polymorphisms and sarcoma susceptibility or prognosis were tested assuming 3 models of inheritance: additive, recessive and dominant. Subgroup analysis based on sarcoma histotype was performed under the additive genetic model. Multivariate logistic regression and multivariate Cox proportional hazard regression analyses were utilized to assess the association between SNPs with patient susceptibility and survival, respectively. Pathway variation analysis was conducted employing the Adaptive Rank Truncated Product method. RESULTS: Six out of the 14 analyzed SNPs were statistically significantly associated with susceptibility or prognosis of soft tissue sarcoma (P <\u20090.05). The present analysis suggested that carriers of the minor allele of the CLOCK polymorphism rs1801260 (C) or of PER2 rs934945 (T) had a reduced predisposition to sarcoma (26% and 35% respectively with the additive model) and liposarcoma (33% and 41% respectively). The minor allele (A) of NPAS2 rs895520 was associated with an increased predisposition to sarcoma of 33% and leiomyosarcoma of 44%. RORA rs339972 C allele was associated with a decreased predisposition to develop sarcoma assuming an additive model (29%) and leiomyosarcoma (36%). PER1 rs3027178 was associated with a reduced predisposition only in liposarcoma subgroup (32%). rs7602358 located upstream PER2 was significantly associated with liposarcoma survival (HR: 1.98; 95% CI 1.02-3.85; P\u2009=\u20090.04). Germline genetic variation in the circadian pathway was associated with the risk of developing soft tissue sarcoma (P\u2009=\u20090.035). CONCLUSIONS: Genetic variation of circadian genes appears to play a role in the determinism of patient susceptibility and prognosis. These findings prompt further studies to fully dissect the molecular mechanisms

UPAYA PENINGKATAN KINERJA SEKRETARIS PADA RNKANTOR KEJAKSAAN TINGGI ACEH

Kesimpulan Dari permasalahan yang telah penulis uraikan pada bab-bab sebelumnya, maka penulis mengambil kesimpulan sebagai berikut :1. Tugas sekretarsis pada Kantor Kejaksaan Tinggi Aceh meliputi pengelolaan surat menyurat, pengelolaan arsip, menata ruangan pimpinan, melayani telepon, menerima tamu, mengatur jadwal rapat, mengatur perjalanan dinas pimpinan dan mengingatkan pimpinan akan janjinya.2. Fasilitas-fasilitas yang dibutuhkan oleh sekretaris dalam meningkatkan kinerjanya di Kejaksaan Tinggi Aceh adalah: Internet, komputer, faximile, printer, telepon, mesin penghancur kertas, ac (air conditioner), dan mesin photo copy.3. Upaya-upaya peningkatan kinerja sekretaris pada Kantor Kejaksaan Tinggi Aceh adalah :a. Mengadakan diklat yang dilaksanakan di Kejaksaan Agung RI untuk sekretaris mengenai peningkatan kinerja sekretaris.b. Memberikan motivasi agar sekretaris dalam melaksanakan pekerjaan akan menghasilkan kerja yang maksimal dan memperoleh manfaat yang optimal.c. Pengelolaan waktud. Mengikuti seminare. Mengembangkan sikap ingin tah

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk.

BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental disorder, autistic patients display a few key characteristics, such as the impaired social interactions and elevated repetitive behaviors, suggesting the perturbation of specific neuronal circuits resulted from abnormal signaling pathways during brain development in ASD. A comprehensive review for autistic signaling mechanisms and interactions may provide a better understanding of ASD etiology and treatment.Main bodyRecent studies on genetic models and ASD patients with several different mutated genes revealed the dysregulation of several key signaling pathways, such as WNT, BMP, SHH, and retinoic acid (RA) signaling. Although no direct evidence of dysfunctional FGF or TGF-β signaling in ASD has been reported so far, a few examples of indirect evidence can be found. This review article summarizes how various genetic and non-genetic factors which have been reported contributing to ASD interact with WNT, BMP/TGF-β, SHH, FGF, and RA signaling pathways. The autism-associated gene ubiquitin-protein ligase E3A (UBE3A) has been reported to influence WNT, BMP, and RA signaling pathways, suggesting crosstalk between various signaling pathways during autistic brain development. Finally, the article comments on what further studies could be performed to gain deeper insights into the understanding of perturbed signaling pathways in the etiology of ASD.ConclusionThe understanding of mechanisms behind various signaling pathways in the etiology of ASD may help to facilitate the identification of potential therapeutic targets and design of new treatment methods

The Effect of Color on Consumer WTP for Farmed Salmon

Atlantic salmon is recognized for its pink-red color. The color is due to deposition of color pigments in the muscles. Wild salmon absorb the pink-red color pigment astaxanthin from the crustaceans they eat. To impart the pink-red color in farmed salmon, synthetically produced astaxanthin is added to their feed. The more astaxanthin, the redder the flesh becomes. In conventional salmon farming, the relatively expensive astaxanthin constitutes approximately 15% of the total feed costs. In this study, we use a stated choice experiment with pictures to investigate consumer willingness to pay (WTP) for salmon with different degrees of redness. The results show that consumer WTP increases with the redness of the salmon. However, when consumers were informed about the origin of the color, the WTP for the above-normal-red salmon was reduced.choice experiment, color, mixed logit, salmon, WTP, Resource /Energy Economics and Policy, Q13, Q22,

Adropin: An endocrine link between the biological clock and cholesterol homeostasis

This article explores two translation models circling around the key issue “equivalence” in translation studies. They are the Jerome Model and the Horace Model. They differentiate from each other in the aspects of the translating priorities and purposes, etc. Moreover, through illustrative examples, the article points out there are intrinsic relationship between the two models, so appropriate application and combination of the two models will not only solve the problem of “equivalence”, but also build up a bridge between source language culture and target language culture