21,687 research outputs found
Rapid Intensification and Propagation of the Dayside Aurora: Large Scale Interplanetary Pressure Pulses (fast shocks)
Previously we described a BRCA1 carrier with a neuronal migration defect and postulated that the brain abnormality was caused by functional nullisomy for BRCA1.1 We now describe another family in which a similar type of neuronal migration defect has occurred in one of female identical twins with a BRCA1 gene mutation (MIM 113705). One twin developed unusually early onset multiple primary breast cancers while the second twin remains cancer free over a decade later. The second twin had long standing epilepsy and focal subcortical heterotopia. We hypothesise that the neuronal migration defect is due to focal nullisomy of the BRCA1 and that the modified breast cancer risk is due to the anti-oestrogenic effects of long term anticonvulsant therapy
Capturing DSN software error messages to improve software, operations and data delivery
Case report: Three patients presented to the Sjogren's syndrome ( SS) Clinic at the National Institute of Dental and Craniofacial Research for screening. The records of patients with SS with a diagnosis of lymphoma were examined to determine whether the diagnosis was made in any of the cases as a result of labial salivary gland (LSG) biopsies. All patients had typical features of primary SS according to the American-European Consensus Group criteria. B cell mucosa associated lymphoid tissue ( MALT) lymphoma was diagnosed based upon the LSG biopsy. Conclusion: This report underlines the advantages of performing LSG biopsies as a routine part of screening for SS, and shows that it may in some instances lead to early diagnosis of MALT lymphomas in patients who show no signs of pre-existing lymphom
Design and implementation of an inter-agency, multi-mission space flight operations network interface
textabstractIn industrialised countries, mortality and morbidity are dominated by age
related chronic degenerative diseases. The health and health care needs of
future populations will be heavily determined by these conditions of old
age. Two opposite scenarios of future morbidity exist: morbidity might
decrease ("compress"), because life span is limited, and the incidence of
disease is postponed. Or morbidity might increase ("expand"), because
death is delayed more than disease incidence. Optimality theory in
evolutionary biology explains senescence as a by product of an optimised
life history. The theory clarifies how senescence is timed by the
competing needs for reproduction and survival, and why this leads to a
generalised deterioration of many functions at many levels. As death and
disease are not independent, future morbidity will depend on duration and
severity of the process of senescence, partly determined by health care,
palliating the disease severity but increasing the disease duration by
postponing death. Even if morbidity might be compressed, health care needs
will surely expand
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