Reparative Reasoning

Peter Ochs' notion of ‘pragmatic reading’ and his wider project of articulating a ‘logic of scripture’ are described in the first part of this article. A distinction is made between Ochs' proposals for how to read scripture and his more technical claims about how scripture itself models a ‘logic of repair’. The term ‘thirdness’ is explained in the contexts of the relations and axioms, hypotheses and communities. His readings of Hans Frei and George Lindbeck are rehearsed briefly in the second section. Their attempts to show that there is nothing ‘behind’ scripture or doctrine, to which the latter supposedly refer, are presented by Ochs as ‘pragmatic’ attempts to repair the rules which generate false oppositions in discussions of scripture and doctrine

RNA content in motor and sensory neurons and surrounding neuroglia of mouse spinal cord under conditions of hypodynamia and following normalization

The differences in the dynamics of reparative processes in RNA metabolism within the neuron-neuroglia unit after the cessation of hyper- and hypodynamia is dicussed. The role of neuroglia is stressed in compensatory, reparative and trophic processes in the nervous system as well as the possibility in an adaptation at the cellular level

Moral Vulnerability and the Task of Reparations

This essay seeks to understand the domain and demands of reparative justice in terms of moral vulnerability. Significant harms raise the question of whether victims stand in truly reciprocal practices of accountability; if they do, they enjoy the power of calling others to account as well as bearing the liability of being accountable to others. In the aftermath of harms, victims’ moral vulnerability is tested: they may be exposed to the insult and injury of discovering that they do not enjoy the moral standing of holding others accountable. While the occasion of reparative justice is significant wrongs and wrongful harms and losses, this essay argues that the aim of reparative practices is not only or even primarily to redress those harms and losses, but to address the moral vulnerability of victims by affirming their status in accountability relations

Making Reparations Possible: Theorizing Reparative Justice

Roll 125a. Quonsets coming down. Image 6 of 26. (11 April, 1954) [PHO 1.125a.6]The Boleslaus Lukaszewski (Father Luke) Photographs contain more than 28,000 images of Saint Louis University people, activities, and events between 1951 and 1970. The photographs were taken by Boleslaus Lukaszewski (Father Luke), a Jesuit priest and member of the University's Philosophy Department faculty

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells

Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New York, NY). Because the toxicity of these materials is mediated by oxidative stress, it seemed possible that the protective effects of IGF-1 and TGF-β were through the enhancement of an endogenous antioxidant mechanism. Methods We used cultured dental pulp cells to determine the mechanism of the protective effects of IGF-1 and TGF-β, focusing on the glutathione system and the role of cystine/glutamate exchange (system xc-). Results We found that the toxicity of Durafill VS and Flow Line was attenuated by the addition of glutathione monoethylester, suggesting a specific role for the cellular antioxidant glutathione. Supporting this hypothesis, we found that IGF-1 and TGF-β were protective against the toxicity of the glutathione synthesis inhibitor buthionine sulfoximine. Because levels of cellular cystine are the limiting factor in the production of glutathione, we tested the effects of IGF-1 and TGF-β on cystine uptake. Both growth factors stimulated system xc–mediated cystine uptake. Furthermore, they attenuated the glutathione depletion induced by Durafill VS and Flow Line. Conclusions The results suggest that IGF-1 and TGF-β are protective through the stimulation of system xc–mediated cystine uptake, leading to maintenance of cellular glutathione. This novel action of growth factors on dental pulp cells has implications not only for preventing toxicity of dental materials but also for the general function of these cells

Punishment in society: the improbable persistence of probation and other community sanctions and measures

This paper aims to explore and explain the key "adaptations" by which community sanctions have sought legitimacy in the wake of the decline of penal welfarism and of the rehabilitative ideal. It shows how community sanctions have survived and even thrived in these shifting social, cultural and penal currents despite various predictions of their demise. The four adaptations that we identify and discuss include, respectively, managerial, punitive, rehabilitative, and reparative aspects. We conclude trying to contribute our analysis of the future prospects for community sanctions and their legitimation.</p

Affirmational and Transformational Values and Practices in the Tolkien Fanfiction Community

Fanfiction based on the legendarium of J.R.R. Tolkien has existed for at least six decades and has been, within the past two, one of the most consistently active online fanfiction communities. Despite this, the fandom has been relatively unstudied by fan studies scholars. This paper considers how Tolkien-based fanfiction corroborates and complicates current theories of fanfiction, focusing especially on a theory proposed by obsession_inc that proposes two types of fandoms: affirmational and transformational. Current thought places fanfiction at the transformational end of the continuum. Using quantitative survey data of authors and readers of Tolkien-based fanfiction, this paper offers evidence that Tolkien-based fanfiction contains significant affirmational components that are an intentional and valued part of many Tolkien fanfiction communities. Authors and readers regard authority, critical functions of fanfiction, and reparative purposes for fanfiction differently than the more commonly studied media fandoms. Yet one cannot say simply that authors of Tolkien-based fanfiction are more affirmational than other fanwriters; instead, evidence shows that authors and readers of Tolkien-based fanfiction navigate transformational and affirmational elements in complex ways, and community cultures often center upon members’ values and practices

Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia

Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that the expression of different neurodegenerative markers increases in CA1 hippocampal area of 4-months-old male rats born by cesarean section and exposed for 19 min to PA. We have also shown that a late treatment with 17β estradiol (daily dose of 250 μg/kg for 3 days) was able to revert the brain alterations observed in those animals. Based on these previous results, the main aim of the present study was to explore the mechanism by which the estrogenic treatment is involved in the reversion of the chronic neurodegenerative conditions induced by PA. We demonstrated that estradiol treatment of adult PA exposed animals induced an increase in estrogen receptor (ER) a and insulin-like growth factor receptor (IGF-1R) protein levels, an activation of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 beta/β-catenin signaling pathway and an increase in Bcl-2/Bax ratio in the hippocampus in comparison to PA exposed animals treated with vehicle. Taking together, our data suggest that the interaction between ERa and IGF-IR, with the subsequent downstream activation, underlies the beneficial effects of estradiol observed in late treatment of PA.Fil: Saraceno, Gustavo Ezequiel. Universite de Bordeaux; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Bellini, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Garcia Segura, Luis Miguel. Consejo Superior de Investigaciones Científicas; España. Instituto de Salud Carlos III; EspañaFil: Capani, Francisco. Universidad Autónoma de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentin