11,943 research outputs found
Unenhanced whole-body MRI versus PET-CT for the detection of prostate cancer metastases after primary treatment
The aim of this study was to evaluate the accuracy of unenhanced whole-body MRI, including whole-body Diffusion Weighted Imaging (DWI), used as a diagnostic modality to detect pathologic lymph nodes and skeletal metastases in patients with prostate cancer (PCa) undergoing restaging after primary treatment
Transfected poly(I:C) activates different dsRNA receptors leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells
Background: Castration-resistant prostate cancer (CRPC) is refractory to chemo-radiotherapy.
Results: Transfection of the synthetic analog of dsRNA poly(I:C) simultaneously stimulates apoptosis and IFN- expression
through different pathways in androgen-independent prostate cancer (PCa) cells.
Conclusion: Dual parallel pathways triggered by distinct receptors activate direct and immunologically mediated antitumor
effects in advanced PCa.
Significance: The proapoptotic/immunoadjuvant poly(I:C)-Lipofectamine complex may offer new therapeutic insights into CRPC
Brca germline mutations in prostate cancer: The future is tailored
: Prostate cancer (PCa) is the second most common neoplasm in men and the fifth leading cause of death worldwide [...]
The Interaction of Botanicals and AMPK Signaling in the Inhibition of Castrate-Resistant Prostate Cancer
Reprogramming of metabolic pathways and abnormal acetylation of DNA are two common features of cancer, including prostate cancer (PCa)
Role of genetic testing for inherited prostate cancer risk: Philadelphia prostate cancer consensus conference 2017
Purpose: Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-dri
New strategy for the identification of prostate cancer: The combination of Proclarix and the prostate health index
Prostate health index (PHI) and, more recently, Proclarix have been proposed as serum biomarkers for prostate cancer (PCa). In this study, we aimed to evaluate Proclarix and PHI for predicting clinically significant prostate cancer (csPCa)
Beyond the immune suppression: the immunotherapy in prostate cancer
Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune
suppression have an important role in their development.We briefly describe the host components that interact with the tumor to
generate an immune suppressive environment involved in PCa promotion and progression.Different tools provide to overcome the
mechanisms of immunosuppression including vaccines and immune checkpoint blockades. With regard to this, we report results
of most recent clinical trials investigating immunotherapy in metastatic PCa (Sipuleucel-T, ipilimumab, tasquinimod, Prostvac-VF,
and GVAX) and provide possible future perspectives combining the immunotherapy to the traditional therapie
Quick assessment of cell-free DNA in seminal fluid and fragment size for early non-invasive prostate cancer diagnosis
Liquid biopsy consists in the quantification and qualification of circulating cell-free DNA (cfDNA) and tumor-derived DNA (ctDNA) for cancer recognition. Recently, the characterization of seminal cfDNA (scfDNA) has been reported as a possible biomarker for prostate cancer (PCa) diagnosis
Signalling pathways and gene expression profiles in prostate cancer
In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathways to progress through the uncontrolled proliferation of cancerous cells. Although the mechanisms of how the cells evade intrinsic or extrinsic signals of death and keep on dividing is not completely understood, there is a plethora of evidence that point to certain signalling molecules that are crucial conveyors of the fine tuning that slightly differs in cancer in comparison to control states. The present chapter provides a detailed description of the key regulators of PCa cell life and unveils their closely communicating proteins that aid in the fine tuning of the cancerous state
- …