28,451 research outputs found

    Laboratory data as a quality indicator of health-care-associated infections in England.

    Get PDF
    Routine diagnostic laboratory results, e.g. numbers of meticillin-resistant Staphylococcus aureus (MRSA) bacteraemias, have been used as health-care-associated infection quality indicators for decades. The English health-care-associated infection quality indicator system was one of the earliest in the world to mandate the collection and public reporting of such data and has been associated with a reduction of MRSA bacteraemias and Clostridium difficile infections but has shown mixed results for other infections. Diagnostic laboratory data vary greatly between hospitals depending not only on the underlying frequency of the infection of interest, but on the case mix, numbers of samples processed and laboratory factors, which limits benchmarking. Further, over-reliance on laboratory reports has led to unintended negative consequences in England. So, while acknowledging the successes of the English system, the authors believe that it should be appraised in light of the goals of quality of care, patient safety, fairness and providing meaningful data, and alternative healthcare-associated infection quality indicator measurements considered

    Planches du Mobilier de la nécropole du Gourjade [planches 103 à 180]

    Get PDF
    Planche 103 Planche 104 Planche 105 Planche 106 Planche 107 Planche 108 Planche 109 Planche 110 Planche 111 Planche 112 Planche 113 Planche 114 Planche 115 Planche 116 Planche 117 Planche 118 Planche 119 Planche 120 Planche 121 Planche 122 Planche 123 Planche 124 Planche 125 Planche 126 Planche 127 Planche 128 Planche 129 Planche 130 Planche 131 Planche 132 Planche 133 Planche 134 Planche 135 Planche 136 Planche 137 Planche 138 Planche 139 Planche 140 Pla..

    Planches du Mobilier de la nécropole du Martinet [Planches 181 à 218]

    Get PDF
    Planche 181 Planche 182 Planche 183 Planche 184 Planche 185 Planche 186 Planche 187 Planche 188 Planche 189 Planche 190 Planche 191 Planche 192 Planche 193 Planche 194 Planche 195 Planche 196 Planche 197 Planche 198 Planche 199 Planche 200 Planche 201 Planche 202 Planche 203 Planche 204 Planche 205 Planche 206 Planche 207 Planche 208 Planche 209 Planche 210 Planche 211 Planche 212 Planche 213 Planche 214 Planche 215 Planche 216 Planche 217 Planche 21

    Planches du Mobilier de la nécropole du Causse [Planches 1 à 102]

    Get PDF
    Planche 1 Planche 2 Planche 3 Planche 4 Planche 5 Planche 6 Planche 7 Planche 8 Planche 9 Planche 10 Planche 11 Planche 11 Planche 13 Planche 14 Planche 15 Planche 16 Planche 17 Planche 18 Planche 19 Planche 20 Planche 21 Planche 22 Planche 23 Planche 24 Planche 25 Planche 26 Planche 27 Planche 28 Planche 29 Planche 30 Planche 31 Planche 32 Planche 33 Planche 34 Planche 35 Planche 36 Planche 37 Planche 38 Planche 39 Planche 40 Planche 41 Planche 42 Pla..

    Victorian Gothic Drama

    Get PDF

    Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.

    No full text
    BACKGROUND: Interferon-gamma (IFNγ) is of key importance in the immune response to Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and novel treatment strategies are needed. We performed a randomized controlled trial to determine whether addition of IFNγ to standard therapy increased the rate of clearance of cryptococcal infection in HIV-associated cryptococcal meningitis. METHODS: Patients were randomized to amphotericin B 1 mg/kg per day and 5FC 100 mg/kg per day for 2 weeks (standard therapy), standard therapy and IFNγ1b 100 μg days 1 and 3 (IFNγ two doses), or standard therapy and IFNγ1b 100 μg days 1, 3, 5, 8, 10 and 12 (IFNγ six doses). Primary outcome was rate of clearance of cryptococcus from the cerebrospinal fluid (CSF) (early fungicidal activity, EFA) calculated from serial quantitative cultures, previously shown to be independently associated with survival. RESULTS: Rate of fungal clearance was significantly faster in IFNγ containing groups than with standard treatment. Mean EFA [log colony forming unit (CFU)/ml per day] was -0.49 with standard treatment, -0.64 with IFNγ two doses, and -0.64 with IFNγ six doses. Difference in EFA was -0.15 [confidence interval (95% CI) -0.02 to -0.27, P=0.02] between standard treatment and IFNγ two doses, and -0.15 (95% CI -0.05 to -0.26, P=0.006) between standard treatment and IFNγ six doses. Mortality was 16% (14/88) at 2 weeks and 31% (27/87) at 10 weeks, with no significant difference between groups. All treatments were well tolerated. CONCLUSION: Addition of short-course IFNγ to standard treatment significantly increased the rate of clearance of cryptococcal infection from the CSF, and was not associated with any increase in adverse events. Two doses of IFNγ are as effective as six doses

    『リチャード二世』(1857)と年代記

    Get PDF

    Volume status in severe malaria (letter)

    Get PDF

    Generically multiple transitive algebraic group actions

    Full text link
    With every nontrivial connected algebraic group GG we associate a positive integer gtd(G){\rm gtd}(G) called the generic transitivity degree of GG and equal to the maximal nn such that there is a nontrivial action of GG on an irreducible algebraic variety XX for which the diagonal action of GG on XnX^n admits an open orbit. We show that gtd(G)2{\rm gtd}(G)\leqslant 2 (respectively, gtd(G)=1{\rm gtd}(G)=\nobreak 1) for all solvable (respectively, nilpotent) GG, and we calculate gtd(G){\rm gtd}(G) for all reductive GG. We prove that if GG is nonabelian reductive, then the above maximal nn is attained for X=G/PX=G/P where PP is a proper maximal parabolic subgroup of GG (but not only for such homogeneous spaces of GG). For every reductive GG and its proper maximal parabolic subgroup PP, we find the maximal rr such that the diagonal action of GG (respectively, a Levi subgroup LL of ~PP) on (G/P)r(G/P)^r admits an open GG-orbit (respectively, LL-orbit). As an application, we obtain upper bounds for the multiplicities of trivial components in some tensor product decompositions. As another application, we classify all the pairs (G,P)(G, P) such that the action of GG on (G/P)3(G/P)^3 admits an open orbit, answering a question of {\sc M. Burger}.Comment: Revised version, 30 page
    corecore