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    Net generation culture

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    Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production

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    Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP. Here we use a genome-scale model of human cell metabolism to investigate the potential metabolic alterations in cells using net zero ATP glycolysis. We uncover a novel pathway for ATP generation that involves reactions from the serine biosynthesis and one-carbon metabolism pathways. This pathway has a predicted two-fold higher flux rate in cells using net zero ATP glycolysis than those using standard glycolysis and generates twice as much ATP with significantly lower rate of lactate- but higher rate of alanine secretion. Thus, in cells using the standard- or the net zero ATP glycolysis pathways a significant portion of the glycolysis flux is always associated with ATP generation, and the ratio between the flux rates of the two pathways determines the rate of ATP generation and lactate and alanine secretion during glycolysis

    Generative Cooperative Net for Image Generation and Data Augmentation

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    How to build a good model for image generation given an abstract concept is a fundamental problem in computer vision. In this paper, we explore a generative model for the task of generating unseen images with desired features. We propose the Generative Cooperative Net (GCN) for image generation. The idea is similar to generative adversarial networks except that the generators and discriminators are trained to work accordingly. Our experiments on hand-written digit generation and facial expression generation show that GCN's two cooperative counterparts (the generator and the classifier) can work together nicely and achieve promising results. We also discovered a usage of such generative model as an data-augmentation tool. Our experiment of applying this method on a recognition task shows that it is very effective comparing to other existing methods. It is easy to set up and could help generate a very large synthesized dataset.Comment: 12 pages, 8 figure

    Long Text Generation via Adversarial Training with Leaked Information

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    Automatically generating coherent and semantically meaningful text has many applications in machine translation, dialogue systems, image captioning, etc. Recently, by combining with policy gradient, Generative Adversarial Nets (GAN) that use a discriminative model to guide the training of the generative model as a reinforcement learning policy has shown promising results in text generation. However, the scalar guiding signal is only available after the entire text has been generated and lacks intermediate information about text structure during the generative process. As such, it limits its success when the length of the generated text samples is long (more than 20 words). In this paper, we propose a new framework, called LeakGAN, to address the problem for long text generation. We allow the discriminative net to leak its own high-level extracted features to the generative net to further help the guidance. The generator incorporates such informative signals into all generation steps through an additional Manager module, which takes the extracted features of current generated words and outputs a latent vector to guide the Worker module for next-word generation. Our extensive experiments on synthetic data and various real-world tasks with Turing test demonstrate that LeakGAN is highly effective in long text generation and also improves the performance in short text generation scenarios. More importantly, without any supervision, LeakGAN would be able to implicitly learn sentence structures only through the interaction between Manager and Worker.Comment: 14 pages, AAAI 201
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