The orienting mouse: An input device with attitude

This paper presents a modified computer mouse, the Orienting Mouse, which delivers orientation as an additional dimension of input; when the mouse is moved on a flat surface it reports, in addition to the conventional x, y translation, angular rotation of the device in the x, y plane. The orienting mouse preserves important properties of the standard mouse; all measurements are relative and movement is tracked only while the mouse is on its flat surface. If the user lets go of the mouse, leaving it on the surface, its position and orientation do not change until it is touched again. Picking the mouse up and putting it down in a different orientation leaves the angle and position unchanged. While the concept of sensing mouse rotation is not new, our work focuses on movement and navigation in 3D, rather than on precision positioning tasks. We describe a number of sample applications developed to test its effectiveness in this context. Specific features exploited and described include (i) an algorithm for calculating the mouse angle which cancels drift between the two sensors, and (ii) the use of angular gearing which avoids unnatural and uncomfortable hand positions when moving through large angles; informal user testing validates this idea

”PENGARUH BERBAGAI DOSIS FILTRAT DAUN COCOR BEBEK \ud (Kalanchoe pinnata L.) TERHADAP PENURUNAN SUHU TUBUH TIKUS \ud PUTIH (Rattus norvegicus) HIPERTERMIA”

Fever is situation of body temperature above normal as effect of make-up of center arrangement of temperature in hipotalamus which in influencing by IL-I. Fever usually happened effect of body of terpapar infection of mikroorganisme (virus, bacterium, parasite). Fever also can \ud because of factor of[is non infection like immured complex, or inflammation (other peradangan). \ud When bacterium or virus come into body, various phabocyte type or leucocyte discharge “ Iihat vitamin cause of fever (endogen pirogen)” later on trigger production of prostaglandin E2 i] anterior hipotalamus, what later;then improve temperature nilai-ambang and happened by fever. \ud leaf of Cocor bebek (Kalanchoe pinnata L.) functioning as antipiretik. Compound Beta of sitosterol dissolve in blood and structure almost loo like with prostaglandin. \ud This research aim to to know influence various dose of filtrat leaf of cocor parrot to degradat ion of white mouse body temperature and to know most effective dose of leaf filtrat of cocor parrot to degradation of white mouse body temperature. \ud This research is executed in Chemical Laboratory UMM. this Method Research is True Experimental Research, with The Pretest-Posttest Control Group Design, sampling technique of Simple Random Sampling with plan attempt of Complete Random Device, with research sampel 24 white mouse tail of male (8 treatment group by 3 restating times). This research variable, that is free variable: dose of filtrat leaf of cocor parrot, varibel depended: degradation of mouse body temperature, control variable: mouse gender, mouse age, heavy of mouse body, vaccine dose of DPT, condition of white mouse cage, food type, and beverage. Technique data collecting is indirect perception because using materials and appliance. Data is here in after analysed with ANAVA and Test of Duncan’S Bedasarkan result of analysis of varians obtained one way F count > F tables of at level of signifikansi 1% meaning there influence various dose of filtrat leaf of cocor parrot to degradation of white mouse body temperature seen is big degradation of body temperature at perception 6 hour after fever. From result of test of Duncan’S 1% dose of filtrat leaf of cocor parrot most effective degrade mouse body temperature reach its dropsy temperature return group of H (dose of filtrat leaf of cocor parrot 4,5 ml / mouse tail) this result not differ reality with group of B (Parasetamol 0,083 mg / mouse tail). \ud Result of research of menunjukan that Leaf filtrat of cocor parrot can be used as drug of antipiretik effective at dose 4,5 ml / mouse tail after 6 hour consume leaf filtrat of cocor bebek body temperature return normally (dropsy)

Intrusion Detection Using Mouse Dynamics

Compared to other behavioural biometrics, mouse dynamics is a less explored area. General purpose data sets containing unrestricted mouse usage data are usually not available. The Balabit data set was released in 2016 for a data science competition, which against the few subjects, can be considered the first adequate publicly available one. This paper presents a performance evaluation study on this data set for impostor detection. The existence of very short test sessions makes this data set challenging. Raw data were segmented into mouse move, point and click and drag and drop types of mouse actions, then several features were extracted. In contrast to keystroke dynamics, mouse data is not sensitive, therefore it is possible to collect negative mouse dynamics data and to use two-class classifiers for impostor detection. Both action- and set of actions-based evaluations were performed. Set of actions-based evaluation achieves 0.92 AUC on the test part of the data set. However, the same type of evaluation conducted on the training part of the data set resulted in maximal AUC (1) using only 13 actions. Drag and drop mouse actions proved to be the best actions for impostor detection.Comment: Submitted to IET Biometrics on 23 May 201

Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB)

Many advances in the field of cancer biology have been made using mouse models of human cancer. The Mouse Tumor Biology (MTB, "http://tumor.informatics.jax.org":http://tumor.informatics.jax.org) database provides web-based access to data on spontaneous and induced tumors from genetically defined mice (inbred, hybrid, mutant, and genetically engineered strains of mice). These data include standardized tumor names and classifications, pathology reports and images, mouse genetics, genomic and cytogenetic changes occurring in the tumor, strain names, tumor frequency and latency, and literature citations.

Although primary source for the data represented in MTB is peer-reviewed scientific literature an increasing amount of data is derived from disparate sources. MTB includes annotated histopathology images and cytogenetic assay images for mouse tumors where these data are available from The Jackson Laboratory’s mouse colonies and from outside contributors. MTB encourages direct submission of mouse tumor data and images from the cancer research community and provides investigators with a web-accessible tool for image submission and annotation. 

Integrated searches of the data in MTB are facilitated by the use of several controlled vocabularies and by adherence to standard nomenclature. MTB also provides links to other related online resources such as the Mouse Genome Database, Mouse Phenome Database, the Biology of the Mammary Gland Web Site, Festing's Listing of Inbred Strains of Mice, the JAX® Mice Web Site, and the Mouse Models of Human Cancers Consortium's Mouse Repository. 

MTB provides access to data on mouse models of cancer via the internet and has been designed to facilitate the selection of experimental models for cancer research, the evaluation of mouse genetic models of human cancer, the review of patterns of mutations in specific cancers, and the identification of genes that are commonly mutated across a spectrum of cancers.

MTB is supported by NCI grant CA089713

Uterine natural killer cell heterogeneity: Lessons from mouse models

Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface

ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.

PurposeZBED4, a protein in cones and Müller cells of human retina, may play important functions as a transcriptional activator of genes expressed in those cells or as a co-activator/repressor of their nuclear hormone receptors. To begin investigating these potential roles of ZBED4, we studied the developmental expression and localization of both the Zbed4 mRNA and protein of mouse retina.Methodsnorthern blots showed the presence of Zbed4 mRNA in retina and other mouse tissues, and western blots showed the nuclear and cytoplasmic expression of Zbed4 at different developmental times. Antibodies against Zbed4 and specific retinal cell markers were used for retinal immunohistochemistry.ResultsZbed4 mRNA was present at different levels in all the mouse tissues analyzed. The Zbed4 protein was barely detectable at embryonic day (E)14.5 but was clearly seen at E16 at both retinal outer and vitreal borders and throughout the retina by E18 and postnatal day 0 (P0). Thereafter, Zbed4 expression was more restricted to the inner retina. While ZBED4 is localized in cones and endfeet of Müller cells of human retina, in adult mouse retina Zbed4 is only detected in Müller cell endfeet and processes. The same localization of Zbed4 was observed in rat retina. In early development, Zbed4 is mainly present in the nuclear fraction of the mouse retina, and in adulthood it becomes more enriched in the cytoplasmic fraction.ConclusionsThe patterns of spatial and temporal expression of Zbed4 in the mouse retina suggest a possible involvement of this protein in retinal morphogenesis and Müller cell function

A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1

Bi-functional shRNA (bi-shRNA), a novel RNA interference (RNAi) effector platform targeting PDX-1 utilizing a systemic DOTAP-Cholesterol delivery vehicle, was studied in three mouse models of progressive pancreatic neoplasia. Species-specific bi-functional PDX-1 shRNA (bi-shRNAPDX-1) lipoplexes inhibited insulin expression and secretion while also substantially inhibiting proliferation of mouse and human cell lines via disruption of cell cycle proteins in vitro. Three cycles of either bi-shRNA<sup>mousePDX-1</sup> or shRNA<sup>mousePDX-1</sup> lipoplexes administered intravenously prevented death from hyperinsulinemia and hypoglycemia in a lethal insulinoma mouse model. Three cycles of shRNA<sup>mousePDX-1</sup> lipoplexes reversed hyperinsulinemia and hypoglycemia in an immune-competent mouse model of pancreatic neoplasia. Moreover, three cycles of the bi-shRNA<sup>humanPDX-1</sup> lipoplexes resulted in near complete ablation of tumor volume and considerably improved survival in a human PANC-1 implanted SCID-mouse model. Human pancreatic neoplasia specimens also stained strongly for PDX-1 expression. Together, these data support the clinical development of a novel therapeutic strategy using systemic bi-shRNA<sup>PDX-1</sup> lipoplexes against pancreatic neoplasia

Identifizierung und Charakterisierung eines neuen Bindeproteins für zyklische Nukleotide

Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate are important intracellular messengers. Binding of cyclic nucleotides controls the activity of protein kinases, ion channels and guanine-nucleotide-exchange factors in many cells. The SCNBP (soluble cyclic nucleotide-binding protein) is a novel uncharacterized protein predicted to comprise a cyclic nucleotide-binding domain. This protein belongs to neither of the known families of effector proteins for cyclic nucleotides. Within 17 distinct species - from marine invertebrates to humans - genes orthologous to the mouse SCNBP are present. Hence, the SCNBP could belong to a novel class of effector proteins for cyclic nucleotides. Northern blot experiments with mouse tissue indicate that the mRNA of SCNBP is expressed predominantly in the testis and by means of in situ hybridization it was specifically detected in spermatocytes. In the present study, SCNBP expression has been analyzed in mouse testis utilizing specific antibodies. I could provide evidence that two distinct SCNBP variants are present in mouse testis. To approach the physiological function of SCNBP, I identified by immunoprecipitation and mass spectrometry proteins in mouse testis that potentially interact with SCNBP. For a comprehensive biochemical study, SCNBP was heterologously expressed in Chinese hamster ovary (CHO) cells. Following fermentation of these cells in a stirred tank bioreactor I purified SCNBP by affinity chromatography

A Comment on Budach's Mouse-in-an-Octant Problem

Budach's Mouse-in-an-Octant Problem (attributed to Lothar Budach in a 1980 article by van Emde Boas and Karpinski) concerns the behaviour of a very simple finite-state machine ("the mouse") moving on the integer two-dimensional grid. Its decidability is apparently still open. This note sketches a proof that an extended version of the problem (a super-mouse) is undecidable.Comment: 3 pages, 2 bibliographic reference