A Supervised STDP-based Training Algorithm for Living Neural Networks

Neural networks have shown great potential in many applications like speech recognition, drug discovery, image classification, and object detection. Neural network models are inspired by biological neural networks, but they are optimized to perform machine learning tasks on digital computers. The proposed work explores the possibilities of using living neural networks in vitro as basic computational elements for machine learning applications. A new supervised STDP-based learning algorithm is proposed in this work, which considers neuron engineering constrains. A 74.7% accuracy is achieved on the MNIST benchmark for handwritten digit recognition.Comment: 5 pages, 3 figures, Accepted by ICASSP 201

Automatic generation of hardware Tree Classifiers

Machine Learning is growing in popularity and spreading across different fields for various applications. Due to this trend, machine learning algorithms use different hardware platforms and are being experimented to obtain high test accuracy and throughput. FPGAs are well-suited hardware platform for machine learning because of its re-programmability and lower power consumption. Programming using FPGAs for machine learning algorithms requires substantial engineering time and effort compared to software implementation. We propose a software assisted design flow to program FPGA for machine learning algorithms using our hardware library. The hardware library is highly parameterized and it accommodates Tree Classifiers. As of now, our library consists of the components required to implement decision trees and random forests. The whole automation is wrapped around using a python script which takes you from the first step of having a dataset and design choices to the last step of having a hardware descriptive code for the trained machine learning model

Automatic differentiation in machine learning: a survey

Derivatives, mostly in the form of gradients and Hessians, are ubiquitous in machine learning. Automatic differentiation (AD), also called algorithmic differentiation or simply "autodiff", is a family of techniques similar to but more general than backpropagation for efficiently and accurately evaluating derivatives of numeric functions expressed as computer programs. AD is a small but established field with applications in areas including computational fluid dynamics, atmospheric sciences, and engineering design optimization. Until very recently, the fields of machine learning and AD have largely been unaware of each other and, in some cases, have independently discovered each other's results. Despite its relevance, general-purpose AD has been missing from the machine learning toolbox, a situation slowly changing with its ongoing adoption under the names "dynamic computational graphs" and "differentiable programming". We survey the intersection of AD and machine learning, cover applications where AD has direct relevance, and address the main implementation techniques. By precisely defining the main differentiation techniques and their interrelationships, we aim to bring clarity to the usage of the terms "autodiff", "automatic differentiation", and "symbolic differentiation" as these are encountered more and more in machine learning settings.Comment: 43 pages, 5 figure

Machine learning-guided directed evolution for protein engineering

Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying physics or biological pathways. To demonstrate ML-guided directed evolution, we introduce the steps required to build ML sequence-function models and use them to guide engineering, making recommendations at each stage. This review covers basic concepts relevant to using ML for protein engineering as well as the current literature and applications of this new engineering paradigm. ML methods accelerate directed evolution by learning from information contained in all measured variants and using that information to select sequences that are likely to be improved. We then provide two case studies that demonstrate the ML-guided directed evolution process. We also look to future opportunities where ML will enable discovery of new protein functions and uncover the relationship between protein sequence and function.Comment: Made significant revisions to focus on aspects most relevant to applying machine learning to speed up directed evolutio

Machine Learning for Software Engineering: Models, Methods, and Applications

Machine Learning (ML) is the discipline that studies methods for automatically inferring models from data. Machine learning has been successfully applied in many areas of software engineering ranging from behaviour extraction, to testing, to bug fixing. Many more applications are yet be defined. However, a better understanding of ML methods, their assumptions and guarantees would help software engineers adopt and identify the appropriate methods for their desired applications. We argue that this choice can be guided by the models one seeks to infer. In this technical briefing, we review and reflect on the applications of ML for software engineering organised according to the models they produce and the methods they use. We introduce the principles of ML, give an overview of some key methods, and present examples of areas of software engineering benefiting from ML. We also discuss the open challenges for reaching the full potential of ML for software engineering and how ML can benefit from software engineering methods