Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD

Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently reinforced behavior. During methylphenidate treatment, impulsivity and hyperactivity are decreased in adolescents with ADHD, but there is little information concerning levels of impulsivity and hyperactivity in adulthood after adolescent methylphenidate treatment is discontinued. The current study evaluated impulsivity, hyperactivity as well as cocaine sensitization during adulthood after adolescent methylphenidate treatment was discontinued in the Spontaneously Hypertensive Rat (SHR) model of ADHD. Treatments consisted of oral methylphenidate (1.5mg/kg) or water vehicle provided Monday-Friday from postnatal days 28-55. During adulthood, impulsivity was measured in SHR and control strains (Wistar Kyoto and Wistar rats) using differential reinforcement of low rate (DRL) schedules. Locomotor activity and cocaine sensitization were measured using the open-field assay. Adult SHR exhibited decreased efficiency of reinforcement under the DRL30 schedule and greater levels of locomotor activity and cocaine sensitization compared to control strains. Compared to vehicle, methylphenidate treatment during adolescence reduced hyperactivity in adult SHR, maintained the lower efficiency of reinforcement, and increased burst responding under DRL30. Cocaine sensitization was not altered following adolescent methylphenidate in adult SHR. In conclusion, adolescent treatment with methylphenidate followed by discontinuation in adulthood had a positive benefit by reducing hyperactivity in adult SHR rats; however, increased burst responding under DRL compared to SHR given vehicle, i.e., elevated impulsivity, constituted an adverse consequence associated with increased risk for cocaine abuse liability.P50 DA005312 - NIDA NIH HHS; R01 DA011716 - NIDA NIH HHS; P50 DA05312 - NIDA NIH HH

Mobile phone dependence, social support and impulsivity in Chinese university students

This study examined the frequency of mobile phone dependence in Chinese university students and explored its association with social support and impulsivity. Altogether, 909 university students were consecutively recruited from a large university in China. Mobile phone use, mobile phone dependence, impulsivity, and social support were measured with standardized instruments. The frequency of possible mobile phone use and mobile phone dependence was 78.3% and 7.4%, respectively. Multinomial logistic regression analyses revealed that compared with no mobile phone dependence, possible mobile phone dependence was significantly associated with being male (p = 0.04, OR = 0.7, 95% CI: 0.4–0.98), excessive mobile phone use (p \u3c 0.001, OR = 1.2, 95% CI: 1.09–1.2), and impulsivity (p \u3c 0.001, OR = 1.05, 95% CI: 1.03–1.06), while mobile phone dependence was associated with length of weekly phone use (p = 0.01, OR = 2.5, 95% CI: 1.2–5.0), excessive mobile phone use (p \u3c 0.001, OR = 1.3, 95% CI: 1.2–1.4), and impulsivity (p \u3c 0.001, OR = 1.08, 95% CI: 1.05–1.1). The frequency of possible mobile phone dependence and mobile phone dependence was high in this sample of Chinese university students. A significant positive association with impulsivity was found, but not with social support

Binge eating disorder In adolescence: the role of alexithymia and impulsivity

Binge Eating Disorder (BED) is a disorder, recently included in DSM-5, often present in adolescence. Several studies highlight that adolescents with BED had high levels of impulsivity and alexithymia. Even though studies have underlined the importance of these variables, no studies have investigated their role on adolescents’ emotional-behavioral functioning. This study proposes to verify if adolescents affected by BED show higher levels of alexithymia and impulsivity than adolescents without diagnosis, and what is their role on adolescents’ emotional-behavioral functioning. Thanks to the collaboration with clinical centers for eating disorders, a group composed by 60 adolescents diagnosed with BED was paired to a 60 healthy controls. Participants completed validated self-report questionnaires investigating levels of alexithymia, impulsivity and emotional-behavioral functioning. Adolescents diagnosed with BED showed higher scores on alexithymia, impulsivity and maladaptive emotional-behavioral functioning than healthy controls. Moreover, alexithymia had a mediating effect on the relationship between impulsivity and emotional-behavioral functioning. These results show that alexithymia is a key variable influencing the emotional-behavioral functioning of adolescents affected by BED. Further studies are needed to also check other variables that might lead to the onset of BED. On the other hand, our findings can help clinicians suggesting the importance of promoting prevention and treatment polices focused on alexithymia

Impulsivity in Sexual Trauma Survivors and their Use of Alcohol and Substances

Impulsivity in Sexual Trauma Survivors and their Use of Alcohol and Substances Kayla McLean, Dept. of Psychology, with Dr. Jasmin Vassileva, Depts. of Psychology and Psychiatry The current study investigates the associations of neurocognitive ‘choice’ impulsivity (delay discounting) and personality ‘trait’ impulsivity (UPPS Impulsive Behavior Scale) with alcohol and substance use among female college students reporting history of sexual trauma. Participants included 2476 students enrolled in the Spit for Science study of college student mental health at VCU. Bivariate correlations were used to examine the associations between lifetime use of alcohol and different types of drugs with delay discounting and trait impulsivity among female students reporting history of sexual trauma (N=688). The results revealed that only cannabis (r=0.10, p\u3c.05) and prescription stimulants (r=0.11, p\u3c.05) were significantly correlated with delay discounting, particularly of rewards of small magnitude. Emotion-related factors of the UPPS trait impulsivity (negative urgency, positive urgency, and sensation seeking), showed positive relationships with cannabis (r=0.34, p\u3c.01), opioids (r=0.27, p\u3c.05), stimulants (r=0.23, p\u3c.05), prescription sedatives (r=0.43, p\u3c.05) and prescription anxiolytics (r=0.43, p\u3c.05). These results may indicate substance use as a means of coping with the emotional effects of sexual trauma.https://scholarscompass.vcu.edu/uresposters/1324/thumbnail.jp

Sleep disturbance and serum ferritin levels associate with high impulsivity and impulse control disorders in male Parkinson\u27s Disease patients

Impulse control disorders (ICDs) occur in a subset of Parkinson’s disease (PD) patients on dopaminergic medications however there are currently no reliable markers to identify patients at risk. Sleep disturbances are more common in patients with an ICD. Serum ferritin levels have been associated with PD disease stage and progression, but have not previously been associated with impulsivity levels. The objective of this study was to determine if serum ferritin levels and sleep disturbance are associated with high traits of impulsivity and ICD in a cohort of PD patients attending a movement disorders clinic. This study assessed impulsiveness in 87 PD patients using the Barratt Impulsiveness Scale. Severity of sleep disturbance was determined using the sleep-related items of the MDS-UPDRS. Serum ferritin, iron and transferrin levels were measured in patients, as well as 36 age-matched healthy controls. Serum ferritin levels were significantly elevated in male PD patients in the high impulsivity group compared to patients in the low (p=.022) and normal range groups (p=.024) and showed a linear increase across the three groups. Sleep disturbance also demonstrated a linear trend, which was most severe in the high impulsivity group (p=.030). A subgroup of 11 male PD patients who fulfilled the DSM-5 criteria for an ICD had significantly higher ferritin levels and more severe sleep disturbance when compared with the remaining male PD cohort. Serum ferritin levels and sleep disturbance severity are highlighted as potential markers for abnormal impulsivity and ICD in PD patients

Impulsivity, Rejection Sensitivity, and Reactions to Stressors in Borderline Personality Disorder

This research investigated baseline impulsivity, rejection sensitivity, and reactions to stressors in individuals with borderline personality disorder compared to healthy individuals and those with avoidant personality disorder . The borderline group showed greater impulsivity than the avoidant and healthy groups both in a delay-discounting task with real monetary rewards and in self-reported reactions to stressors; moreover, these findings could not be explained by co-occurring substance use disorders. Distress reactions to stressors were equally elevated in both personality disorder groups (relative to the healthy group). The borderline and avoidant groups also reported more maladaptive reactions to a stressor of an interpersonal versus non-interpersonal nature, whereas the healthy group did not. Finally, self-reported impulsive reactions to stressors were associated with baseline impulsivity in the delay-discounting task, and greater self-reported reactivity to interpersonal than non-interpersonal stressors was associated with rejection sensitivity. This research highlights distinct vulnerabilities contributing to impulsive behavior in borderline personality disorder

How do impulsivity traits influence problem gambling through gambling motives? The role of perceived gambling risk/benefits.

Although substantial research suggests that motivations have been found to mediate the relationships between impulsivity traits and various forms of substance use, no studies have examined how gambling motives may mediate the relationships between impulsivity traits and problem gambling. The primary purpose of this study was to test an integrative model linking impulsivity traits and gambling problems, evaluating the mediating effects of gambling motives. Participants were 594 students (73% male; mean age =19.92; SD=2.91) enrolled in public high schools or universities. Young people who tend to act rashly in response to extremely positive moods, showed higher enhancement and coping motives, which in turn were positively related to gambling problems. Individuals with higher levels of sensation seeking were more likely to have higher levels of enhancement motives, which in turn were also positively related to gambling problems. The model was examined in several groups, separately for the level of perceived gambling risk/benefits (lower perceived gambling risk, higher perceived gambling risk, lower perceived gambling benefits, and higher perceived gambling benefits). There were significant differences between these groups for this division. These findings suggest that prevention and/or treatment strategies might want to consider the model’s variables, including impulsivity traits and gambling motives, in accordance with individual levels of perceived gambling risk/benefits

Impulsivity, Emotional Intelligence, and Alcohol Consumption in Young People: A Mediation Analysis

Alcohol consumption in young people is a public health problem. Due to the harmful consequences and the large population using alcoholic substances, it would be important to determine the biological, psychological, and social factors associated with alcohol use and abuse. The main object of this study is to explore which components of impulsivity, according to the main theoretical models, have predictive power regarding alcohol consumption in young people. A secondary objective is to determine if emotional intelligence has a mediating role between the components of impulsivity and alcohol consumption, and thus specifically contribute to the knowledge about the mediation processes between those variables that are involved in the initiation and maintenance of alcohol consumption. For this purpose, 384 participants were recruited (83.1% females, n = 319), with mean age of 20.46 years (SD = 1.90; range 18-25). All participants were alcohol consumers at the beginning of the study. Data collection was conducted via online survey; impulsivity was evaluated by several questionnaires (Sensation Seeking Scale Form V, Barratt Impulsivity Scales 11, and Sensitivity to Punishment and Sensitivity to Reward), and emotional intelligence was evaluated by the Trait Meta-Mood Scale. The results reveal that the dimension of disinhibition (a dimension of the sensation search scale) significantly has the highest predictive value on alcohol consumption. Moreover, our data show that the total effect and direct effect of disinhibition on frequency of alcohol consumption were both significant. The mediating role of emotional intelligence in this process was also significant. These findings show which variables should be considered to prevent alcohol consumption in young peopl