Chromospherically active stars in the ROTSE-1 database: paper 6. Variables 126 - 149

Another 24 new chromospherically active stars are presented, which were found in the ROTSE-1 database: GSC 02268-00394, GSC 01224-00894, GSC 00648-00579, GSC 02865-01987, GSC 01851-01202, GSC 00124-00551, GSC 00150-01109, GSC 01339-00572, GSC 02968-01511, GSC 03005-00885, GSC 01083-00698, GSC 03941-00354, GSC 04450-00134, GSC 05163-01764, GSC 01095-00848, GSC 04459-00659, USNO A2.0 1275-14029063, GSC 04247-00903, GSC 01656-01276, GSC 02197-01430, GSC 02227-01294, GSC 04480-00965, GSC 01159-00245, GSC 02237-01574. For one of these stars (GSC 00124-00551), further observations were made using a TeleView 509/5.0 telescope with a CCD camera SIGMA1603 and IR-cutting filter in Velden, Germany

Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence.

Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always develop tumor recurrence. Glioblastoma stem cells (GSC), a minor subpopulation within the tumor mass, have been recently characterized as tumor-initiating cells and hypothesized to be responsible for post-treatment recurrence because of their enhanced radio-/chemo-resistant phenotype and ability to reconstitute tumors in mouse brains. Genome-wide expression profile analysis uncovered molecular properties of GSC distinct from their differentiated, proliferative progeny that comprise the majority of the tumor mass. In contrast to the hyperproliferative and hyperangiogenic phenotype of glioblastoma tumors, GSC possess neuroectodermal properties and express genes associated with neural stem cells, radial glial cells, and neural crest cells, as well as portray a migratory, quiescent, and undifferentiated phenotype. Thus, cell cycle-targeted radio-chemotherapy, which aims to kill fast-growing tumor cells, may not completely eliminate glioblastoma tumors. To prevent tumor recurrence, a strategy targeting essential gene pathways of GSC must be identified and incorporated into the standard treatment regimen. Identifying intrinsic and extrinsic cues by which GSC maintain stemness properties and sustain both tumorigenesis and anti-apoptotic features may provide new insights into potentially curative strategies for treating brain cancers

Constant beamwidth generalised sidelobe canceller

In this paper, we proposed a constant beamwidth discrete Fourier transform (DFT) beamformer based on the generalised sidelobe canceller (GSC). Broadband signals are decomposed into frequency bins which are grouped into octaves and tapered individually. The resulting beampattern possesses constant beamwidth across the entire operating spectrum, thus ensuring uniform spatial resolution. Further incorporation of the GSC allows adaptive nulling of interference to coincide with uniform resolution, enhancing the beamformer’s performance. However, modification to the constraint equation of the standard GSC is required to account for the frequency-dependent weighting of sensors

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide.

BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue. Here we used MGMT-expressing glioblastoma stem cells (GSC) lines as a model for investigating the molecular mechanism underlying TMZ resistance, while aiming to explore a new treatment strategy designed to possibly overcome resistance to the clinically relevant dose of TMZ (35 μM).MethodsMGMT-expressing GSC cultures are resistant to TMZ, and IC50 (half maximal inhibitory concentration) is estimated at around 500 μM. Clonogenic GSC surviving 500 μM TMZ (GSC-500 μM TMZ), were isolated. Molecular signatures were identified via comparative analysis of expression microarray against parental GSC (GSC-parental). The recombinant protein of top downregulated signature was used as a single agent or in combination with TMZ, for evaluating therapeutic effects of treatment of GSC.ResultsThe molecular signatures characterized an activation of protective stress responses in GSC-500 μM TMZ, mainly including biotransformation/detoxification of xenobiotics, blocked endoplasmic reticulum stress-mediated apoptosis, epithelial-to-mesenchymal transition (EMT), and inhibited growth/differentiation. Bone morphogenetic protein 7 (BMP7) was identified as the top down-regulated gene in GSC-500 μM TMZ. Although augmenting BMP7 signaling in GSC by exogenous BMP7 treatment did not effectively stop GSC growth, it markedly sensitized both GSC-500 μM TMZ and GSC-parental to 35 μM TMZ treatment, leading to loss of self-renewal and migration capacity. BMP7 treatment induced senescence of GSC cultures and suppressed mRNA expression of CD133, MGMT, and ATP-binding cassette drug efflux transporters (ABCB1, ABCG2), as well as reconfigured transcriptional profiles in GSC by downregulating genes associated with EMT/migration/invasion, stemness, inflammation/immune response, and cell proliferation/tumorigenesis. BMP7 treatment significantly prolonged survival time of animals intracranially inoculated with GSC when compared to those untreated or treated with TMZ alone (p = 0.0017), whereas combination of two agents further extended animal survival compared to BMP7 alone (p = 0.0489).ConclusionsThese data support the view that reduced endogenous BMP7 expression/signaling in GSC may contribute to maintained stemness, EMT, and chemoresistant phenotype, suggesting that BMP7 treatment may provide a novel strategy in combination with TMZ for an effective treatment of glioblastoma exhibiting unmethylated MGMT

New SPB stars in the field of the young open cluster NGC 2244 discovered by the MOST photometric satellite

During two weeks of nearly continuous optical photometry of the young open cluster NGC 2244 obtained by the MOST satellite, we discovered two new SPB stars, GSC 00154-00785 and GSC 00154-01871. We present frequency analyses of the MOST light curves of these stars, which reveal two oscillation frequencies (0.61 and 0.71 c/d) in GSC 00154-00785 and two (0.40 and 0.51 c/d) in GSC 00154-01871. These frequency ranges are consistent with g-modes of $\ell \leq 2$ excited in models of main-sequence or pre-main-sequence (PMS) stars of masses 4.5 - 5 $M_{\odot}$ and solar composition $(X, Z)= (0.7, 0.02)$. Published proper motion measurements and radial velocities are insufficient to establish unambiguously cluster membership for these two stars. However, the PMS models which fit best their eigenspectra have ages consistent with NGC 2244. If cluster membership can be confirmed, these would be the first known PMS SPB stars, and would open a new window on testing asteroseismically the interior structures of PMS stars.Comment: accepted for publication in MNRA

On the Minimum Distance of Generalized Spatially Coupled LDPC Codes

Families of generalized spatially-coupled low-density parity-check (GSC-LDPC) code ensembles can be formed by terminating protograph-based generalized LDPC convolutional (GLDPCC) codes. It has previously been shown that ensembles of GSC-LDPC codes constructed from a protograph have better iterative decoding thresholds than their block code counterparts, and that, for large termination lengths, their thresholds coincide with the maximum a-posteriori (MAP) decoding threshold of the underlying generalized LDPC block code ensemble. Here we show that, in addition to their excellent iterative decoding thresholds, ensembles of GSC-LDPC codes are asymptotically good and have large minimum distance growth rates.Comment: Submitted to the IEEE International Symposium on Information Theory 201

On the role of ground state correlations in hypernuclear non-mesonic weak decay

The contribution of ground state correlations (GSC) to the non--mesonic weak decay of $^{12}_\Lambda$C and other medium to heavy hypernuclei is studied within a nuclear matter formalism implemented in a local density approximation. We adopt a weak transition potential including the exchange of the complete octets of pseudoscalar and vector mesons as well as a residual strong interaction modeled on the Bonn potential. Leading GSC contributions, at first order in the residual strong interaction, are introduced on the same footing for all isospin channels of one-- and two--nucleon induced decays. Together with fermion antisymmetrization, GSC turn out to be important for an accurate determination of the decay widths. Besides opening the two--nucleon stimulated decay channels, for $^{12}_\Lambda$C GSC are responsible for 14% of the rate $\Gamma_1$ while increasing the $\Gamma_{n}/\Gamma_{p}$ ratio by 4%. Our final results for $^{12}_\Lambda$C are: $\Gamma_{\rm NM}=0.98$, $\Gamma_{n}/\Gamma_{p}=0.34$ and $\Gamma_2/\Gamma_{\rm NM}=0.26$. The saturation property of $\Gamma_{\rm NM}$ with increasing hypernuclear mass number is clearly observed. The agreement with data of our predictions for $\Gamma_{\rm NM}$, $\Gamma_n/\Gamma_p$ and $\Gamma_2$ is rather good.Comment: 32 pages, 9 figure

GSC configuration management plan

The tools and methods used for the configuration management of the artifacts (including software and documentation) associated with the Guidance and Control Software (GCS) project are described. The GCS project is part of a software error studies research program. Three implementations of GCS are being produced in order to study the fundamental characteristics of the software failure process. The Code Management System (CMS) is used to track and retrieve versions of the documentation and software. Application of the CMS for this project is described and the numbering scheme is delineated for the versions of the project artifacts