Влияние природного геропротектора на репаративные процессы в слизистой оболочке желудка крыс

Изучены репаративные свойства пептидного биорегулятора, созданного на основе экстракта из слизистой оболочки желудка животных, в экспериментальной модели преждевременного старени

Влияние природного геропротектора на компенсаторную регенерацию печени после частичной гепатэктомии у крыс

Рассматривается влияние геропротектора Вентвил, созданного на основе экстракта из печени телят на крысах в условиях эксперимент

Cambios morfologicos de la glandula Pineal luego de eliminar la estimulacion fotica en las ratas

73 p.La glándula pineal es una pequeña estructura ubicada en el techo del diencéfalo en la gran mayoría de los animales vertebrados, su principal función es la de jugar un rol importante en la regulación de ritmos circadianos, tales como sueño-vigilia, además de secretar melatonina, hormona con fuerte efecto sobre la acción gonadal, efectos oncostático, geroprotector y antioxidante. La función de producción de la melatonina está a cargo del pinealocito, célula principal de esta glándula que junto a las células intersticiales son los principales componentes celulares de la glándula. El objetivo de este estudio es la observación de los posibles cambios morfológicos a nivel histológico, representados en la densidad de pinealocitos y vasos sanguíneos de la glándula pineal, luego de eliminar la estimulación fótica en ratas, por medio de daño retiniano con alcohol etílico. Para el estudio se utilizaron 18 ratas hembras de la raza Sprague Dawley divididas en 2 grupos, el primero (Grupo I) actuó como control, y el segundo (Grupo II) fue sometido a una lesión a nivel retiniano, por medio de alcoholización bilateral de ambos bulbos oculares, las cuales luego de 3 semanas fueron sacrificadas, para analizar mediante cortes histológicos seriados teñidos con H/E, la glándula. Los resultados encontrados fueron que para el grupo II en el cual fue eliminada la estimulación fótica, la densidad de pinealocitos fue mayor (518.73) en comparación con el grupo I (345.22) en los cuales la estimulación fue normal, resultados que fueron estadísticamente significativos. En conclusión la estimulación lumínica juega un importante rol en el control de la función pineal, existiendo considerables cambios a nivel histológico, tanto a nivel vascular como celular

Fish oil supplements, longevity and aging

Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can increase lifespan, affecting pathways like inflammation and oxidation thought to be involved in the regulation of aging. Could fish oil and its omega-3 fatty acids act as geroprotectors? Probably not. A new study by Strong et al. challenges the role for fish oil supplementation in aging. Using a large cohort of genetically heterogeneous mice in three sites, part of the Interventions Testing Program of the NIA, Strong et al. show that fish oil supplementation at either low or high dosages has no effect on the lifespan of male or female mice. Although it is still possible that fish oil supplementation has health benefits for specific age-related diseases, it does not appear to slow aging or have longevity benefits

Correction by peptide bioregulators of micro- and ultramicroscopic changes in the pineal gland caused by stress under light deprivation

It has been established, that immobilizing stress causes decreasing of light cell's amount in pineal gland, which are the main source of melatonin production like under usual lighting and like under light deprivation. Light deprivation, that stimulates pineal gland function, also provides activation of pre-melatonin biosynthesis that increased production of endogenous melatonin

Oxidative stress enzymes and mitochondrial bioenergetics in wild Liza saliens exposed to heavy metals

The Esmoriz-Paramos coastal lagoon represents an ecosystem of great physical and ecological significance. However, as a result of industrial, agricultural and antropogenic activities this habitat has been progressively degrading over the last decades. The heavy metal contamination is an important factor to the decline of sediments quality and may adversely affect fish health. In the present work the leaping grey mullet Liza saliens was studied because it is the dominant endemic species in the lagoon. It is a filter feeder and also being a detritus-mud feeder, it is therefore exposed to contaminated sediments

Chiyu extract stimulates antioxidant defense ability in senescence-accelerated mice

The effect of chiyu extract on antioxidant defense alteration in senescence-accelerated mice (SAM) was examined. Comparison with AKR/N Slc mice, a strain consistent with SAM but exhibiting normal aging, showed a lower glutathione (GSH) level and glutathione/glutathione disulfide (GSH/ GSSG) ratio in the kidney and liver of SAM, whereas malondialdehyde (MDA), a lipid peroxidation product, was increased significantly. Administration of chiyu extract increased the GSH level and GSH/ GSSG ratio, and markedly suppressed MDA production. On the other hand, detection of renal enzymes related to the glutathione redox cycle showed that catalase and glutathione peroxidase activities were largely decreased in SAM, whereas chiyu extract reversed this tendency. The reduced activities of hepatic catalase and glutathione reductase were increased significantly by the extract. These findings suggest that a decline of the antioxidant defense system occurs in SAM, and that chiyu extract may have a beneficial effect in ameliorating oxidative stress or damage. 老化促進マウス(SAM)の抗酸化防御機構に対し,地楡エキスがいかなる影響を及ぼしているかについて,SAMと同じ系統ではあるが,通常の老化過程を辿るAKR/N Slcマウスと比較検討した。その結果,SAMの腎,肝グルタチオンレベルとグルクチオン/グルタチオンジスルフィド比は低下し,脂質過酸化物のマロンジアルデヒドは逆に有意に上昇していたが,地楡エキスを投与したSAMでは,これらパラメーターがいずれも改善していた。一方,グルタチオン酸化還元サイクルに関係している酵素のうち,腎ではカタラーゼとグルクチオンペルオキシダーゼ活性がSAMで著しく低下し,地楡エキス投与によってこれら酵素の活性が回復していた。肝においても低下していたカタラーゼとグルタチオンレダクターゼ活性がエキス投与により著しく回復していた。これら所見は,SAMで認められる抗酸化防御系の低下が,地楡エキスによって是正されることを示唆するものである

Season of birth influences life span of Mediterranean fruit flies, rats and mice

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Prevention of Protein Glycation by Natural Compounds

Non-enzymatic protein glycosylation (glycation) contributes to many diseases and aging of organisms. It can be expected that inhibition of glycation may prolong the lifespan. The search for inhibitors of glycation, mainly using in vitro models, has identified natural compounds able to prevent glycation, especially polyphenols and other natural antioxidants. Extrapolation of results of in vitro studies on the in vivo situation is not straightforward due to differences in the conditions and mechanism of glycation, and bioavailability problems. Nevertheless, available data allow to postulate that enrichment of diet in natural anti-glycating agents may attenuate glycation and, in consequence, ageing