30,792 research outputs found

    Mechanistic insights into the regulation of inflammatory pathology by A20

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    Nanocomposite cotton gauze cloth with in situ generated silver, copper and their binary metal nanoparticles by bioreduction method

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    ¬© 2022 Taylor & Francis Group, LLC. This is the accepted manuscript version of an article which has been published in final form at: https://doi.org/10.1080/24701556.2021.2025096In the present work, the authors prepared nanocomposite cotton gauze cloth (NCGC) by in situ generating the nanoparticles of silver (ANPs) and copper (CuNPs) and their binary metallic nanoparticles (BMNPs) using aqueous extraction of Azadirachta indica leaves as a reducing agent. The NCGCs had roughly spherical AgNPs, CuNPs and BMNPs in the size range of 50‚Äď120 nm. The corresponding mean size of the spherical AgNPs, CuNPs and BMNPs was 94, 89 and 87 nm respectively. The participation of the hydroxyl and amino groups of the leaf extract in the generation of the metal nanoparticles in the NCGCs was established by studying the chemical interactions. All the NCGC specimens exhibited significant antibacterial activity. However, the NCGCs with BMNPs had higher antibacterial efficiency when compared to those with homo metal nanoparticles. Hence, the NCGC with generated BMNPs can be effectively used as antibacterial wound dressing material.Peer reviewe

    Environmental surveillance for Salmonella Typhi as a tool to estimate the incidence of typhoid fever in low-income populations.

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    Background: The World Health Organisation recommends prioritised use of recently prequalified typhoid conjugate vaccines in countries with the highest incidence of typhoid fever. However, representative typhoid surveillance data are lacking in many low-income countries because of the costs and challenges of diagnostic clinical microbiology. Environmental surveillance (ES) of Salmonella Typhi in sewage and wastewater using molecular methods may offer a low-cost alternative, but its performance in comparison with clinical surveillance has not been assessed. Methods: We developed a harmonised protocol for typhoid ES and its implementation in communities in India and Malawi where it will be compared with findings from hospital-based surveillance for typhoid fever. The protocol includes methods for ES site selection based on geospatial analysis, grab and trap sample collection at sewage and wastewater sites, and laboratory methods for sample processing, concentration and quantitative polymerase chain reaction (PCR) to detect Salmonella Typhi. The optimal locations for ES sites based on digital elevation models and mapping of sewage and river networks are described for each community and their suitability confirmed through field investigation. We will compare the prevalence and abundance of Salmonella Typhi in ES samples collected each month over a 12-month period to the incidence of blood culture confirmed typhoid cases recorded at referral hospitals serving the study areas. Conclusions: If environmental detection of Salmonella Typhi correlates with the incidence of typhoid fever estimated through clinical surveillance, typhoid ES may be a powerful and low-cost tool to estimate the local burden of typhoid fever and support the introduction of typhoid conjugate vaccines. Typhoid ES could also allow the impact of vaccination to be assessed and rapidly identify circulation of drug resistant strains

    Diagnostic Survey of Honeybee Diseases, Pests and Predators in Bale Zone Southeast Oromia Region, Ethiopia

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    A cross-sectional study was conducted on parasitic honeybee diseases, pests and predators in Bale. For the study questionnaires and diagnostic survey were employed.  A sample of adult worker bees and brood for major honeybee diseases were taken and analyzed in veterinary laboratory of respective districts of the study. SPSS version 20 was used for data analysis using descriptive statistics (frequency, percentage and chi-square. From the present study, the major challenge declared by beekeepers includes pests and predators, lack of bee forage, absconding and mass death of bee colonies. Regarding to honeybee pests and predators, the most important identified were honey badger, spiders ant, wax moth, bee-eater birds, small hive beetles and monkeys. The study indicated the overall mean prevalence of Nosema apis, Amoeba mellifera, Varro mites,  bee lice, wax moth, small hives beetles  were 79.17 %, 79.16%, 72.22%, 18.06%, 40.27% and 54.2 % respectively. However, the current diagnosis was not detected AFB, EFB, and trachea mites during laboratory sample analysis. Agro ecology and hive types were identified as risk factors for prevalence of honeybee diseases and pests.  Further study on prevalence of seasonal honeybee diseases and outbreak of honeybee diseases and pests is could be very important. Keywords: Honeybee, Nosema apis, Malpighamoeba mellificae, diagnostic, disease, pests DOI: 10.7176/JBAH/13-6-01 Publication date: April 30th 202

    SARS-CoV-2 Infection in Captive Hippos (Hippopotamus amphibius), Belgium.

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    Two adult female hippos in Zoo Antwerp who were naturally infected with SARS-CoV-2 showed nasal discharge for a few days. Virus was detected by immunocytochemistry and PCR in nasal swab samples and by PCR in faeces and pool water. Serology was also positive. No treatment was necessary

    A review of process intensified CO2 capture in RPB for sustainability and contribution to industrial net zero

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    Carbon dioxide (CO2), a significant greenhouse gas released from power plants and industries, substantially impacts climate change; minimizing it and achieving carbon net zero is essential globally. In the direction of reducing CO2 emissions into the atmosphere, post-combustion carbon capture from large point CO2 emitters by chemical absorption involving the absorption of this gas in a capturing fluid is a commonly used and efficacious mechanism. Researchers have worked on the process using conventional columns. However, process intensification technology is required because of the high capital cost, the absorption column height, and the traditional columns’ low energy efficiency. Rotating packed bed (RPB) process intensification equipment has been identified as a suitable technology for enhanced carbon capture using an absorbing fluid. This article reviews and discusses recent model developments in the post-combustion CO2 capture process intensification using rotating packed beds. In the literature, various researchers have developed steady-state mathematical models regarding mass balance and energy balance equations in gas and liquid phases using ordinary or partial differential equations. Due to the circular shape, the equations are considered in a radial direction and have been solved using a numerical approach and simulated using different software platforms, viz. MATLAB, FORTRAN, and gPROMS. A comparison of various correlations has been presented. The models predict the mole fraction of absorbed CO2 and correspond well with the experimental results. Along with these models, an experimental data review on rotating packed bed is also included in this work

    Northern Powerhouses: the homes of the industrial elite, c.1780-1875

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    This thesis explores the world of the industrial elites of Manchester and Liverpool in the period c.1780-1875, through their houses. The homes of the industrial elites, namely merchants and manufacturers, were extremely important tangible communicators of wealth, taste, and comfort. Whilst status-building was closely connected to the house, this thesis argues that the industrial elites carved their own identities into their domestic spheres and that emulation was not solely linked with aspiration. The findings of this thesis are based around its three research aims regarding the changing location of houses in Manchester and Liverpool in the eighteenth and nineteenth centuries, the appearance and use of houses, and the daily routines and involvement of the industrial elite in their domestic routines. An analysis of elite residential patterns in Manchester and Liverpool across the eighteenth and nineteenth centuries has created a more nuanced look at urban geographies of the region in this period. Though some residential patterns differed because of economic and political structure, a key finding has been that the process of suburbanisation in and around Manchester and Liverpool commenced earlier than previous scholarship has suggested. Suburbanisation among the elites began in the latter decades of the eighteenth century and into the early decades of the nineteenth century, with elite suburban communities being firmly established by the 1820s. This thesis discovered that despite socio-economic and political differences, the industrial elites of Manchester and Liverpool used their houses, gardens, and landed estates in very similar ways. This was a result of conformity which arose from emulation at both a community-based level and the emulation and aspiration of elite, gentrified lifestyle. Also, the merchants and manufacturers analysed within this work were involved in their home at every level of domesticity, from the construction of the house to the financial management of the household, although this latter theme was often a cooperative effort between spouses and family members, adding more to our understanding of gender, domesticity, and familial relations. Through detailed case studies and a combination of sources, the private lives of the industrial elites have been revaluated and redefined, including showing how their houses functions metaphorically and in reality

    Supernatural crossing in Republican Chinese fiction, 1920s‚Äď1940s

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    This dissertation studies supernatural narratives in Chinese fiction from the mid-1920s to the 1940s. The literary works present phenomena or elements that are or appear to be supernatural, many of which remain marginal or overlooked in Sinophone and Anglophone academia. These sources are situated in the May Fourth/New Culture ideological context, where supernatural narratives had to make way for the progressive intellectuals‚Äô literary realism and their allegorical application of supernatural motifs. In the face of realism, supernatural narratives paled, dismissed as impractical fantasies that distract one from facing and tackling real life. Nevertheless, I argue that the supernatural narratives do not probe into another mystical dimension that might co-exist alongside the empirical world. Rather, they imagine various cases of the characters‚Äô crossing to voice their discontent with contemporary society or to reflect on the notion of reality. ‚ÄúCrossing‚ÄĚ relates to characters‚Äô acts or processes of trespassing the boundary that separates the supernatural from the conventional natural world, thus entailing encounters and interaction between the natural and the supernatural. The dissertation examines how crossing, as a narrative device, disturbs accustomed and mundane situations, releases hidden tensions, and discloses repressed truths in Republican fiction. There are five types of crossing in the supernatural narratives. Type 1 is the crossing into ‚Äúhaunted‚ÄĚ houses. This includes (intangible) human agency crossing into domestic spaces and revealing secrets and truths concealed by the scary, feigned ‚Äėhaunting‚Äô, thus exposing the hidden evil and the other house occupiers‚Äô silenced, suffocated state. Type 2 is men crossing into female ghosts‚Äô apparitional residences. The female ghosts allude to heart-breaking, traumatic experiences in socio-historical reality, evoking sympathetic concern for suffering individuals who are caught in social upheavals. Type 3 is the crossing from reality into the characters‚Äô delusional/hallucinatory realities. While they physically remain in the empirical world, the characters‚Äô abnormal perceptions lead them to exclusive, delirious, and quasi-supernatural experiences of reality. Their crossings blur the concrete boundaries between the real and the unreal on the mental level: their abnormal perceptions construct a significant, meaningful reality for them, which may be as real as the commonly regarded objective reality. Type 4 is the crossing into the netherworld modelled on the real world in the authors‚Äô observation and bears a spectrum of satirised objects of the Republican society. The last type is immortal visitors crossing into the human world. This type satirises humanity‚Äôs vices and destructive potential. The primary sources demonstrate their writers‚Äô witty passion to play with super--natural notions and imagery (such as ghosts, demons, and immortals) and stitch them into vivid, engaging scenes using techniques such as the gothic, the grotesque, and the satirical, in order to evoke sentiments such as terror, horror, disgust, dis--orientation, or awe, all in service of their insights into realist issues. The works also creatively tailor traditional Chinese modes and motifs, which exemplifies the revival of Republican interest in traditional cultural heritage. The supernatural narratives may amaze or disturb the reader at first, but what is more shocking, unpleasantly nudging, or thought-provoking is the problematic society and people‚Äôs lives that the supernatural (misunderstandings) eventually reveals. They present a more compre--hensive treatment of reality than Republican literature with its revolutionary consciousness surrounding class struggle. The critical perspectives of the supernatural narratives include domestic space, unacknowledged history and marginal individuals, abnormal mentality, and pervasive weaknesses in humanity. The crossing and supernatural narratives function as a means of better understanding the lived reality. This study gathers diverse primary sources written by Republican writers from various educational and political backgrounds and interprets them from a rare perspective, thus filling a research gap. It promotes a fuller view of supernatural narratives in twentieth-century Chinese literature. In terms of reflecting the social and personal reality of the Republican era, the supernatural narratives supplement the realist fiction of the time

    Translating erasure: Proposing auto-theory as a practice for artistic enquiry and analysis while comprehending personal grief

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    Erasure as an artistic technique has developed in my moving image work after my father's passing. I export videos into sequences of thousands of images and erase outlines of the targeted objects in each frame. The repetitive and low conscious labour is a way to ease the agony and to grieve my father. Hours compressed into thousands of frames, turning into a glimpse of illusion and leaving a ghostly emptiness on the images. Both its visual presentation and making reflect the life events and encounters I've experienced in the UK and Taiwan in the past years. I consider an artwork embodies interconnected relationships between one's personal impulses and artistic training. As an art student, I have found it challenging to describe such a creative process with conventional academic writing. Within a construct that inclines to present thoughts as reasonable and rational arguments, my personal experiences and the intensity of feeling seem out of place. Within an academic framework, how can I make an argument out of how I have developed the erasure in my artwork to perform the grief, fading memories of a loved one, existential crisis and what's in-between? Through auto-theoretical approaches to writing and making of moving image work, this research aims to build a structure that can express both the intimate and intellectual aspects of an art practice. This writing up process interweaves my personal stories that motivate my artistic expression into art theories. The memories about my late father, my relationship with languages, and my lives between the UK and Taiwan meet with different artists' uses of erasure. As the conversations between the introspections and theoretical analysis accumulate, my writing and moving image work unravel an art journey that encompasses the nuances and struggles I've experienced as an international student. Within the search for an ideal model to illustrate an art practice, this research further generates profound understandings of memory, grief, loss, language, conflicted identities and cultural belonging

    Desarrollo de materiales bioactivos con potencial aplicación odontológica mediante impregnación asistida por CO2 supercrítico

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    Tesis (DCI)--FCEFN-UNC, 2021En esta tesis se estudi√≥ el proceso de incorporaci√≥n de eugenol en fibras de poliamida 6 (PA6) mediante la impregnaci√≥n asistida por CO2 supercr√≠tico para desarrollar un material con propiedades antimicrobianas con una potencial aplicaci√≥n odontol√≥gica. Para este prop√≥sito, se construy√≥ un equipo de alta presi√≥n en el que se llevaron a cabo m√ļltiples ensayos de impregnaci√≥n de eugenol y de sorci√≥n de CO2 en un hilo dental comercial de PA6 en distintas condiciones de presi√≥n y temperatura (40 ‚Äď 60 ¬įC y 8 ‚Äď 12 MPa). Con el fin de encontrar las mejores condiciones del proceso de impregnaci√≥n, se evalu√≥ la influencia de diferentes variables operativas (presi√≥n, temperatura, tiempo de contacto y velocidad de despresurizaci√≥n) sobre la cantidad de eugenol impregnada en el material. Adem√°s, se estudiaron los principales fen√≥menos difusivos que ocurren en el proceso de impregnaci√≥n del eugenol en condiciones supercr√≠ticas. Para ello, se hicieron ensayos de cin√©tica de sorci√≥n del CO2 y del eugenol en PA6 a diferentes condiciones de presi√≥n y temperatura y se determin√≥ el coeficiente de difusi√≥n aparente para ambas especies en este pol√≠mero. Por otra parte, se evaluaron las propiedades finales del material impregnado, analizando las propiedades mec√°nicas, t√©rmicas y morfol√≥gicas del material original, presurizado con CO2 e impregnado con eugenol. Adicionalmente se evalu√≥ la actividad antimicrobiana del material impregnado frente a dos bacterias comunes (Escherichia coli y Staphylococcus aureus). Asimismo, se estudi√≥ la migraci√≥n del compuesto activo impregnado en aire y en saliva artificial, obteniendo datos importantes para el potencial desarrollo de un producto comercial, como la estimaci√≥n de la vida √ļtil, el tipo de envase, y tipo de aplicaci√≥n del producto. Finalmente, se hizo un dise√Īo y dimensionamiento de un proceso industrial para la impregnaci√≥n de eugenol en bobinas de fibras de PA6 en CO2 supercr√≠tico, a partir de los datos de eficiencia de impregnaci√≥n y par√°metros difusivos del hilo impregnado con eugenol previamente obtenidos, realizando el dise√Īo de la bobina, el equipo impregnador y los c√°lculos de sus principales requerimientos de masa y energ√≠a.Fil: Mosquera Ruiz, Jos√© Euliser. Universidad Nacional de C√≥rdoba. Facultad de Ciencias Exactas, F√≠sicas y Naturales; Argentina.Fil: Mosquera Ruiz, Jos√© Euliser. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Instituto de Investigaci√≥n y Desarrollo en Ingenier√≠a de Procesos y Qu√≠mica Aplicada; Argentina
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