Hemodynamics and Endothelial Cell Biology in Cardiovascular Diseases

Atherosclerotic plaques develop preferentially in curved and branching arteries in-vivo. Lipids and inflammatory cells accumulation in the intimal layer of the arterial wall is considered as the main driving mechanism in the disease progression. Evidences suggest that this focal distribution of plaques may result from the combination of systemic risk factors including high plasma cholesterol, smoking, diabetis, hypertension or genetic pre-disposition and local hemodynamic risk factors such as low and oscillatory flows. The exact mechanism of the biological and biomechanical interactions between the endothelium, blood flow and the growing lesion underneath still remains unclear. This thesis is a study on the relationship between biomechanical factors found in proatherogenic flow and endothelial inflammation. The thesis focuses in particular on the effect of secondary flows on wall shear stress and mass transport distribution. To that end, we have combined different techniques from flow imaging, 3D flow reconstruction, vascular biology and mathematical simulation of biological network. In particular, shear stress is involved in the regulation of the pro-inflammatory transcription factor nuclear factor -kB (NF-kB) and the vasoregulator Nitric Oxide. The role of endothelial Nitric Oxide and wall shear stress on NF-kB activation is still controversial. We investigated here the hypothesis that NO negatively regulates NF- kB activation in flow chamber with sheared endothelial cells and using a mathematical model of the NF-kB-NO pathway. Understanding the underlying relationship between hemodynamic factors and inflammatory cells transport to the wall may contribute to the development of better therapies or interventional practices to treat patients with atherosclerotic diseases

Ellalou Dimmock Honors Voice Recital, November 8, 2005

This is the concert program of the Ellalou Dimmock Honors Voice Recital performance on Tuesday, November 8, 2005 at 8:00 p.m., at the Concert Hall, 855 Commonwealth Avenue. Works performed were "La ci darem la mano" from "Don Giovanni" by Wolfgang Amadeus Mozart, "Amore traditore, Cupido, du verräter" BWV 203 by Johann Sebastian Bach, "Ariettes Oubliées" by Claude Debussy, "In der Fremde," "Intermezzo," "Waldesgespräch," "Mondnacht," "Auf einer Burg," and "Frühlingsnacht" from "Liederkreis," Op. 39 by Robert Schumann, "The Lilacs," Op. 21 No. 5 by Sergey Rachmaninov, "Oh, nver sing to me again," Op. 4 No. 4 by S. Rachmaninov, "Spring Waters," Op. 14 No. 11 by S. Rachmaninov, "Don Quichotte à Dulcinée by Maurice Ravel, and "Caro! Bella!" from "Giulio Cesare" by George Frideric Handel. Digitization for Boston University Concert Programs was supported by the Boston University Center for the Humanities Library Endowed Fund

Utilisation de l'urée pour l'alimentation des veaux au sevrage

A Madagascar, au Centre de Kianjasoa, 66 jeunes bovins (3/4 brahma X 1/4 Zébu Malgache) ont été alimentés durant leur sevrage avec une ration à base de foin, donné à volonté, et additionné d'urée. Les résultats pondéraux ainsi que les bilans nutritionnel et économique sont donnés et discutés. L'effet favorable de l'urée dans une alimentation des veaux à base de foin s'est vu entièrement confirmé. (Résumé d'auteur

Realistic shell-model calculations for proton particle-neutron hole nuclei around 132Sn

We have performed shell-model calculations for nuclei with proton particles and neutron holes around 132Sn using a realistic effective interaction derived from the CD-Bonn nucleon-nucleon potential. For the proton-neutron channel this is explicitly done in the particle-hole formalism. The calculated results are compared with the available experimental data, particular attention being focused on the proton particle-neutron hole multiplets. A very good agreement is obtained for all the four nuclei considered, 132Sb, 130Sb, 133Te and 131Sb. We predict many low-energy states which have no experimental counterpart. This may stimulate, and be helpful to, future experiments.Comment: 8 pages, 6 figures, to be published on Physical Review

Correlation Functions in 2-Dimensional Integrable Quantum Field Theories

In this talk I discuss the form factor approach used to compute correlation functions of integrable models in two dimensions. The Sinh-Gordon model is our basic example. Using Watson's and the recursive equations satisfied by matrix elements of local operators, I present the computation of the form factors of the elementary field $\phi(x)$ and the stress-energy tensor $T_{\mu\nu}(x)$ of the theory.Comment: 19pp, LATEX version, (talk at Como Conference on ``Integrable Quantum Field Theories''

An Evening of Song, January 30, 1996

This is the concert program of the An Evening of Song performance on Tuesday, January 30, 1996 at 6:00 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts. Works performed were "Die Liebende Schreibt" from Six Songs, Op. 86, No. 3 by Felix Mendelssohn-Bartholdy; from Lieder aus Wilhelm Meister, Op. 98 by Robert Schumann; "Der Gang zum Liebschen" from Sieben Lieder, Op. 48, No. 1, "Minnelied" from Fünf Lieder, Op. 71, No. 5, and "Meine Liebe ist grün" from Lieder, Op. 63, No. 5 by Johannes Brahms; "Pantomime" from Quatre Chansons de Jeunesse, "Apparition" from Quatre Chansons de Jeunesse, and "Erstes Lied der Ophelia" from Drei Lieder der Ophelia, Op. 67, No. 1 by Richard Strauss; Suleikas zweiter Gesang, Op. 31, No. 2 by Franz Schubert; "Lied der Suleika" from Myrthen, Op. 25, No. 9 by Robert Schumann; "Suleika" from Six Songs by Robert, Op. 34, No. 4 by Felix Mendelssohn-Bartholdy; Drei Ophelia Lieder by Hermann Reutter; from Quatre Chansons de Jeunesse by Claude Debussy; "Ständchen" from Fünf Lieder, Op. 106, No. 1 nd "Therese" from Fünf Lieder, Op. 86, No. 1 by Johannes Brahms; La Diva de l'Empire by Erik Satie; from Don Quichotte à Dulcinée by Maurice Ravel, and from Sieben Frühe Lieder by Alban Berg. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund

Note sur les essais de charge de pâturage en République du Sénégal

Depuis quelques années, de nombreux pâturages ouest-africains ont été étudiés et cartographiés par photo-interprétation et on a établi des parcelles témoins pour leur étude dynamique. On a effectué des expériences de charge durant de courtes ou longues périodes; mais en tenant compte des grandes fluctuations de charge d'une année sur l'autre et d'une région à l'autre, aucune charge moyenne n'a pu être déterminée; de 3,4 à 8 ha annuels peuvent être nécessaires pour un animal de 200 kg. Parallèlement on a calculé la digestibilité du foin naturel qui, s'il a un coefficient de digestibilité bas en matières azotées (de 20,40 à 25,85 p. 100) a des coefficients de cellulose et d'extraction non azotée très élevés, respectivement 58,71 à 65,96 p. 100 et 44,24 à 52,60 p. 100. La valeur fourragère varie de 0,37 à 0,46 U.F., ce qui équivaut à un bon foin produit dans les pays tempéré

Surname studies with genetics

Genetic studies of surnames are briefly reviewed. In particular, such DNA studies can sometimes provide clues to a surname's meaning. A few surnames are being found to include unusually large single families, which are far more populous than computer simulations for monogamous families predict, suggesting that they might best be explained by their getting off to a fast start through polygyny or concubines: Brehon Law in Ireland and medieval Welsh Law were relatively accepting of polygyny. The Plant surname in the Welsh Marches largely comprises an abnormally large single family and this favours the Welsh meaning '[many] children', though various other meanings for this surname have been suggested. The surnames Meates, Meats, Mates, Mate and Myatt in north Staffordshire and Ireland belong to a single family and appear to have derived from the female forename Maiot