Modelling and simulation of magnetic induction in magnetic particle imaging system

In the last century, tomographic imaging has become an essential tool for disease diagnosis. There are several dominant tomographic imaging methods used for medical application such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and single photon emission computed tomography (SPECT)

A Compressed Sensing Algorithm for Sparse-View Pinhole Single Photon Emission Computed Tomography

Single Photon Emission Computed Tomography (SPECT) systems are being developed with multiple cameras and without gantry rotation to provide rapid dynamic acquisitions. However, the resulting data is angularly undersampled, due to the limited number of views. We propose a novel reconstruction algorithm for sparse-view SPECT based on Compressed Sensing (CS) theory. The algorithm models Poisson noise by modifying the Iterative Hard Thresholding algorithm to minimize the Kullback-Leibler (KL) distance by gradient descent. Because the underlying objects of SPECT images are expected to be smooth, a discrete wavelet transform (DWT) using an orthogonal spline wavelet kernel is used as the sparsifying transform. Preliminary feasibility of the algorithm was tested on simulated data of a phantom consisting of two Gaussian distributions. Single-pinhole projection data with Poisson noise were simulated at 128, 60, 15, 10, and 5 views over 360 degrees. Image quality was assessed using the coefficient of variation and the relative contrast between the two objects in the phantom. Overall, the results demonstrate preliminary feasibility of the proposed CS algorithm for sparse-view SPECT imaging

Role Of Tc99m-Besilesomab Scan With The Added Benefit Of Single Photon Emission Computed Tomography/ Computed Tomography (Spect/Ct) In Localising Infection

Imbasan Tc99m-besilesomab dengan manfaat tambahan Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT) untuk mengenal pasti fokus lokasi infeksi dalam tubuh pesakit Role of Tc99m-besilesomab scan with the added benefit of Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT) in localising infectio

On the data dependent filtration techniques in the single-photon emission computed tomography

We develop space variant data dependent filtration techniques for single-photon emission computed tomography (SPECT) data modeled as the 2D attenuated ray transform with Poisson noise. In these studies we proceed, in particular, from some results of our recent work [J.-P.Guillement, R.G.Novikov, A noise property analysis of single-photon emission computed tomography data, Inverse Problems 20, pp.175-198, (2004)]. We illustrate our filtrations in the framework of simulated SPECT imaging involving (generalized and classical) FBP algorithms

Probable Early-Onset Alzheimer's Disease in an Apolipoprotein E2 Homozygote

Objective: To describe a case of early-onset Alzheimer's disease (AD) in an apolipoprotein (Apo) epsilon 2/epsilon 2 homozygote. Background: Apo epsilon 2/epsilon 2 is the rarest of the ApoE genotypes, representing only 1.4% of the population. Cognitive decline in ApoE epsilon 2 homozygotes has rarely been reported. Case Report/Methods: We report a 58-year-old Apo epsilon 2/epsilon 2 female who meets clinical criteria for probable AD as confirmed by neuropsychological testing, positron emission/computed tomography scan, CSF analysis and genetic screening for known mutations. Results: The clinical course is typical of AD, with progressive cognitive and functional decline. Conclusion: Clinically confirmed early-onset AD is atypical in ApoE2 homozygotes but can occur. Copyright (C) 2010 S. Karger AG, Base

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography

Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT). More recently, the radioiodinated (R,S)-stereoisomer of 123I-INER, 123I-NKJ64, has been synthesized and preliminary evaluation in rats has been reported. This article reports the brain distribution and pharmacokinetic properties of 123I-NKJ64 in baboons and compares results with 123I-INER data in the same species. SPECT studies were conducted in two ovariectomized adult female baboons using two different protocols: (1) bolus of 123I-INER or 123I-NKJ64; and (2) bolus plus constant infusion of 123I-NKJ64 with reboxetine (2.0 mg/kg) administration at equilibrium. Following bolus injection, both radiotracers rapidly and avidly entered the baboon brain. The regional brain accumulation of 123I-NKJ64 did not match the known distribution of NAT in baboon brain, contrasting with previous results obtained in rats. Conversely, the regional distribution of 123I-INER was consistent with known distribution of NAT in baboon brain. No displacement of 123I-NKJ64 was observed following administration of reboxetine. This contrasts with previous data obtained for 123I-INER, where 60% of specific binding was displaced by a lower dose of reboxetine. These data suggest that 123I-NKJ64 may lack affinity and selectivity for NAT in baboon brain and 123I-INER is the most promising iodinated reboxetine analogue developed to date for in vivo imaging of NAT in brain using SPECT. This study highlights the importance of species differences during radiotracer development and the stereochemical configuration of analogues of reboxetine in vivo. Synapse, 2012. -® 2012 Wiley Periodicals, In

Sternal vascularity after harvesting of the internal thoracic artery

Reply to "Assessment of Sternal Vascularity With Single Photon Emission Computed Tomography After Harvesting of the Internal Thoracic Artery" by Cohen et al.peer-reviewe