A New Catalytic Prins Cyclization Leading to Oxa- and Azacycles

4 páginas, 2 esquemas, 5 tablas.A new Prins cyclization process that builds up one carbon−carbon bond, one heteroatom-carbon bond, and one halogen-carbon bond, (in an oxa- and azacycle) relies on an iron catalyst system formed from Fe(acac)3 and trimethylsilyl halide. The method displays a broad substrate scope and is economical, environmentally friendly, and experimentally simple. This catalytic method permits the construction of chloro, bromo and iodo heterocycles, by the suitable combination of iron(III) source, the corresponding trimethylsilyl halide and the solvent, in high yields.This research was supported by the Ministerio de Educación y Ciencia of Spain, cofinanced by the European Regional Development Fund (CTQ2005- 09074-C02-01/BQU), FICIC, the Spanish MSC ISCIII (RETICS RD06/0020/1046) and the Canary Islands Government. R.M.C. thanks the Spanish MEC for a FPU fellowship.Peer reviewe