Health Conversion Foundations

The phenomenon of nonprofit to for-profit conversion in the health industry represents the largest redeployment of charitable assets in history. Because the converting nonprofit health organization is presumed to have provided public benefit before the conversion and because the nonprofit assets have been built by and on behalf of the public, state laws typically require that converting organizations preserve their charitable assets in order to maintain the level of public benefit provided before the conversion. Often these assets are used to endow a new foundation. These foundations -- commonly called conversion foundations -- are the subject of this paper. Over the past two decades, billions of dollars in charitable assets have transferred from the health care industry into organized philanthropy, and billions more will no doubt do so.The trend of health conversions is a very recent but quickly accelerating one: The first conversion foundation was created in 1973, and over the next ten years, only four were created; most were established in the mid-1980s or mid- to late 1990s. Most are fewer than ten years old: 59% were formed between 1994 and 1999, and an additional 11% since 1999

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrPres

Prion diseases are associated with the conversion of the normal cellular prion protein, PrPc, to the abnormal, disease-associated form, PrPSc. This conversion can be mimicked in vitro by using a cell-free conversion assay. It has recently been shown that this assay can be modified to use bacterial recombinant PrP as substrate and mimic the in vivo transmission characteristics of rodent scrapie. Here, it is demonstrated that the assay replicates the ovine polymorphism barriers of scrapie transmission. In addition, the recently identified ovine PrP variant ARL168Q, which is associated with resistance of sheep to experimental BSE, modulates the cell-free conversion of ovine recombinant PrP to PrPres by three different types of PrPSc, reducing conversion efficiencies to levels similar to those of the ovine resistance-associated ARR variant. Also, the equivalent variant in mice (L164) is resistant to conversion by 87V scrapie. Together, these results suggest a significant role for this position and/or amino acid in conversion

The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD.

Hippocampal pathology occurs early in Alzheimer disease (AD), and atrophy, measured by volumes and volume changes, may predict which subjects will develop AD. Measures of the temporal horn (TH), which is situated adjacent to the hippocampus, may also indicate early changes in AD. Previous studies suggest that these metrics can predict conversion from amnestic mild cognitive impairment (MCI) to AD with conversion and volume change measured concurrently. However, the ability of these metrics to predict future conversion has not been investigated. We compared the abilities of hippocampal, TH, and global measures to predict future conversion from MCI to AD. TH, hippocampi, whole brain, and ventricles were measured using baseline and 12-month scans. Boundary shift integral was used to measure the rate of change. We investigated the prediction of conversion between 12 and 24 months in subjects classified as MCI from baseline to 12 months. All measures were predictive of future conversion. Local and global rates of change were similarly predictive of conversion. There was evidence that the TH expansion rate is more predictive than the hippocampal atrophy rate (P=0.023) and that the TH expansion rate is more predictive than the TH volume (P=0.036). Prodromal atrophy rates may be useful predictors of future conversion to sporadic AD from amnestic MCI

Solar energy conversion

If solar energy is to become a practical alternative to fossil fuels, we must have efficient ways to convert photons into electricity, fuel, and heat. The need for better conversion technologies is a driving force behind many recent developments in biology, materials, and especially nanoscience

Low-noise on-chip frequency conversion by four-wave-mixing Bragg scattering in SiNx waveguides

Low-noise, tunable wavelength-conversion through non-degenerate four-wave mixing Bragg scattering in SiNx waveguides is experimentally demonstrated. Finite element method simulations of waveguide dispersion are used with the split-step Fourier method to predict device performance, and indicate a strong dependence of the conversion efficiency on phase matching, which is controlled by the waveguide geometry. Two 1550 nm wavelength band pulsed pumps are used to achieve tunable conversion of a 980 nm signal over a range of 5 nm with a peak conversion efficiency of \approx 5 %. The demonstrated Bragg scattering process is suitable for frequency conversion of quantum states of light.Comment: 4 pages, two columns, 3 figure

Radix Conversion for IEEE754-2008 Mixed Radix Floating-Point Arithmetic

Conversion between binary and decimal floating-point representations is ubiquitous. Floating-point radix conversion means converting both the exponent and the mantissa. We develop an atomic operation for FP radix conversion with simple straight-line algorithm, suitable for hardware design. Exponent conversion is performed with a small multiplication and a lookup table. It yields the correct result without error. Mantissa conversion uses a few multiplications and a small lookup table that is shared amongst all types of conversions. The accuracy changes by adjusting the computing precision

A conversion disorder

Interrogating the relationship between reading, writing and ‘conversion disorder’, this creative-critical essay explores the eversion of the glove in the work of Woolf, Genet, Freud and Derrida. Gathering together reflections on gloves and glove anaesthesia, doubles and pairs, and flowers and the death knell (glas), it offers a series of literary, philosophical and psychoanalytic conversions in order to return to and rethink the question of ‘disorder’

Photon-graviton pair conversion

We consider the conversion of gravitons and photons as a four-wave mixing process. A nonlinear coupled systems of equations involving two gravitons and two photons is obtained, and the energy exchange between the different degrees of freedom is found. The scattering amplitudes are obtained, from which a crossection for incoherent processes can be found. An analytical example is given, and applications to the early Universe are discussed.Comment: 5 pages, slightly modified as compared to v1, to appear in Class. Quantum Grav. as a Letter to the Edito