Sparse whole-genome sequencing identifies two loci for major depressive disorder.

Major depressive disorder (MDD), one of the most frequently encountered forms of mental illness and a leading cause of disability worldwide, poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified, despite analysis of more than 9,000 cases. Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10(-10)), the other in an intron of the LHPP gene (P = 6.45 × 10(-12)). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness

Southern Regional Health Consortium

Georgia Health Policy Center performed an assessment of Georgia's public health system to more clearly define public health's "core business" especially as it relates to the broader system of health and health care in the state; gain an accurate understanding of the public's perception of the role of public health; examine the areas of existing service overlap; and investigate opportunities for increased collaboration with various health care providers and stakeholders

HELIN Consortium OPAC Report

Report of the HELIN OPAC Task Force, a group appointed by the HELIN Directors to review the Innovative Interfaces online public access catalog under 2006 release driven by WebPAC Pro. The task force met during the fall of 2006

State and Local Government Sweatfree Consortium: Why the Consortium is Good for Business

This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide. Special emphasis is placed on labor rights, working conditions, labor market changes, and union organizing.ilrf_businesstalkingpoints.pdf: 11 downloads, before Oct. 1, 2020

Case Summary: Gina Form Bra (Thailand)

WRC report on its investigation of working conditions in the Gina Form Bra factory in Thailand. Includes a discussion of the closure of the factory despite pressure by the WRC and workers’ efforts to keep it open

Worker Rights Consortium Assessment re Far East Garment Textile and First Apparel (Thailand): Findings, Recommendations, and Status Report

WRC reports on its assessment of labor violations at the Far East factory in Thailand. Includes a discussion of logistics of the assessment and recommendations for the company to remediate the problems

Worker Rights Consortium Assessment re Hugger de Honduras and Vision Tex (Honduras): Findings, Recommendations and Status Report

WRC report on its investigation of the failure of two factories in Honduras to provide compensation to their workers. Also describes WRC’s efforts to pressure Nike to obtain compliance to labor standards from its contractors

Case Summary: Teerapat Industries (Thailand)

WRC report on its investigation of labor violations at a Teerapat Industries factory in Thailand following complaints by concerned workers. Includes a description of WRC’s intervention on behalf of workers