Steady state and (bi-) stability evaluation of simple protease signalling networks

Signal transduction networks are complex, as are their mathematical models. Gaining a deeper understanding requires a system analysis. Important aspects are the number, location and stability of steady states. In particular, bistability has been recognised as an important feature to achieve molecular switching. This paper compares different model structures and analysis methods particularly useful for bistability analysis. The biological applications include proteolytic cascades as, for example, encountered in the apoptotic signalling pathway or in the blood clotting system. We compare three model structures containing zero-order, inhibitor and cooperative ultrasensitive reactions, all known to achieve bistability. The combination of phase plane and bifurcation analysis provides an illustrative and comprehensive understanding of how bistability can be achieved and indicates how robust this behaviour is. Experimentally, some so-called “inactive” components were shown to have a residual activity. This has been mostly ignored in mathematical models. Our analysis reveals that bistability is only mildly affected in the case of zero-order or inhibitor ultrasensitivity. However, the case where bistability is achieved by cooperative ultrasensitivity is severely affected by this perturbation

Bistability in Feshbach Resonance

A coupled atom-molecule condensate with an intraspecies Feshbach resonance is employed to explore matter wave bistability both in the presence and in the absence of a unidirectional optical ring cavity. In particular, a set of conditions are derived that allow the threshold for bistability, due both to two-body s-wave scatterings and to cavity-mediated two-body interactions, to be determined analytically. The latter bistability is found to support, not only transitions between a mixed (atom-molecule) state and a pure molecular state as in the former bistability, but also transitions between two distinct mixed states.Comment: 6 pages + 3 figures; To appear in Jounal of Modern Optics, Special Issue - Festschrift in Honor of Lorenzo Narducc

Power and wavelength polarization bistability with very wide hysteresis cycles in a 1550nm-VCSEL subject to orthogonal optical injection

We have measured optical power and wavelength polarization bistability in a 1550nm-Vertical Cavity Surface-Emitting Laser (VCSEL) subject to orthogonally-polarized optical injection into the orthogonal polarization of the fundamental transverse mode. Optical bistability with very wide hysteresis cycles, up to four times wider than previously reported results has been measured for both the optical power and wavelength domain. We also report the experimental observation of three different shapes of polarization bistability, anticlockwise, clockwise and X-Shape bistability, all of them with wide hysteresis cycles. This rich variety of behaviour at the important wavelength of 1550 nm offers promise for the use of VCSELs for all-optical signal processing and optical switching/routing applications. ©2009 Optical Society of America

Optical bistability for two-level atoms in a standing-wave cavity

Observations of optical bistability are reported for a system composed of multiple atomic beams passing through a high-finesse optical cavity. Both the transmitted power and the intracavity fluorescent intensity have been recorded as functions of incident laser power for zero cavity and atomic detunings. A quantitative study has been made of the evolution of the steady-state switching intensities from well below the critical onset of bistability to well above this point. The results show reasonable agreement with a Gaussian-beam theory of optical bistability, but systematic departures are noted

Bistability for asymmetric discrete random walks

We show that asymmetric time-continuous discrete random walks can display bistability for equal values of Jauslin's shifting parameters. The bistability becomes more pronounced at increased asymmetry parameterComment: Follow-up note to hep-th/9411026[PRE 51, 5112 (May 95)], one fig. include