Early-life adversity accelerates cellular ageing and affects adult inflammation: experimental evidence from the European starling

Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simultaneously. We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall and begging effort for a period of 10 days. The experimental treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juvenile period. For telomere attrition, amount of food and begging effort exerted additive effects. Only the combination of low food amount and high begging effort increased DNA damage. We then measured two markers of inflammation, high-sensitivity C-reactive protein and interleukin-6, when the birds were adults. The experimental treatments affected both inflammatory markers, though the patterns were complex and different for each marker. The effect of the experimental treatments on adult interleukin-6 was partially mediated by increased juvenile DNA damage. Our results show that both nutritional input and begging effort in the nestling period affect cellular ageing and adult inflammation in the starling. However, the pattern of effects is different for different biomarkers measured at different time points

Effects of increased begging and vitamin E supplements on oxidative stress and fledging probability

Offspring often use begging displays to demand food from parents. Begging is supposed to be a costly behavior, and oxidative stress is one potential cost of begging. We experimentally manipulated the begging intensity of great tit nestlings and the availability of vitamin E, an important antioxidant. The results suggest that oxidative stress is rather a minor cost of begging. However, nestlings supplemented with vitamin E were more likely to fledg

Analysis of Beggars in Modern Nepal

This paper attempts to classify the beggars of modern Nepal according to their professional and their art of begging. By observing their principles of begging, we have classified them into 6 categories and each category has been explained in brief

Begging for Change: Research findings and recommendations on forced child begging in Albania/Greece, India and Senegal

This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide. Special emphasis is placed on labor rights, working conditions, labor market changes, and union organizing.ASI_2009_CL_Albania_Begging_for_Change.pdf: 1139 downloads, before Oct. 1, 2020

Oppy and Modal Theistic Proofs

I argue that Graham Oppy’s attempt to redefend his charge that all modal theistic arguments “must be question-begging” is unsuccessful. Oppy’s attempt to show that theism and modal concretism are compatible is not only tangential for his purposes, it is marred by a misunderstanding of theism, and vulnerable to a counterexample that actually demonstrates incompatibility. Moreover, the notion of begging the question employed by Oppy against the theist is seen to be far too permissive

Kant’s (Non-Question-Begging) Refutation of Cartesian Scepticism

Interpreters of Kant’s Refutation of Idealism face a dilemma: it seems to either beg the question against the Cartesian sceptic or else offer a disappointingly Berkeleyan conclusion. In this article I offer an interpretation of the Refutation on which it does not beg the question against the Cartesian sceptic. After defending a principle about question-begging, I identify four premises concerning our representations that there are textual reasons to think Kant might be implicitly assuming. Using those assumptions, I offer a reconstruction of Kant’s Refutation that avoids the interpretative dilemma, though difficult questions about the argument remain

Begging the Question: Permanent Income and Social Mobility

The extent of social mobility is one of three key considerations - along with living standards and the level of inequality - in any assessment of a society’s economic merits. The intergenerational correlation (IGC) between the incomes of parents and their children provides a summary statistic of income mobility, where low income correlations reflect high mobility, whilst high correlations reflect low mobility. As such it has become the primary measure of this variable. The main alternative measure, in the form of mobility matrices, is unable to provide a single measure of mobility but has the advantage of capturing variation in mobility across different parts of the income distribution.

Selection, inheritance, and the evolution of parent-offspring interactions

Very few studies have examined parent-offspring interactions from a quantitative genetic perspective. We used a cross-fostering design and measured genetic correlations and components of social selection arising from two parental and two offspring behaviors in the burying beetle Nicrophorus vespilloides. Genetic correlations were assessed by examining behavior of relatives independent of common social influences. We found positive genetic correlations between all pairs of behaviors, including between parent and offspring behaviors. Patterns of selection were assessed by standardized performance and selection gradients. Parental provisioning had positive effects on offspring performance and fitness, while remaining near the larvae without feeding them had negative effects. Begging had positive effects on offspring performance and fitness, while increased competition among siblings had negative effects. Coadaptations between parenting and offspring behavior appear to be maintained by genetic correlations and functional trade-offs; parents that feed their offspring more also spend more time in the area where they can forage for themselves. Families with high levels of begging have high levels of sibling competition. Integrating information from genetics and selection thus provides a general explanation for why variation persists in seemingly beneficial traits expressed in parent-offspring interactions and illustrates why it is important to measure functionally related suites of behaviors

Effects of begging on growth rates of nestling chicks

We investigated whether an increase in begging levels delays growth of chicks. In experiment 1, we hand-reared nine pairs of ring dove squabs, divided into a control and a begging group. All squabs received similar amounts of food, but those in the begging group had to beg for a prolonged period in order to be fed, while squabs in the control group received food without begging. Squabs stopped responding to the treatment after 10 days and, at that time, there was no effect of induced begging on their body mass. In experiment 2, we hand-reared 27 pairs of magpie chicks for 3 days. The design of experiment 2 was similar to that of experiment 1. Daily food intake and begging affected growth rates. On average, chicks in the begging group grew 0.8 g/day less than control chicks, which represents a decrease of 8.15% in growth rate. Because growth is usually positively associated with expected fitness, this demonstrates that begging is a costly behavior, an assumption routinely made in models of begging behavior.Peer Reviewe