Image Enhancement and Noise Reduction Using Modified Delay-Multiply-and-Sum Beamformer: Application to Medical Photoacoustic Imaging

Photoacoustic imaging (PAI) is an emerging biomedical imaging modality capable of providing both high contrast and high resolution of optical and UltraSound (US) imaging. When a short duration laser pulse illuminates the tissue as a target of imaging, tissue induces US waves and detected waves can be used to reconstruct optical absorption distribution. Since receiving part of PA consists of US waves, a large number of beamforming algorithms in US imaging can be applied on PA imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm in US imaging. However, make use of DAS beamformer leads to low resolution images and large scale of off-axis signals contribution. To address these problems a new paradigm namely Delay-Multiply-and-Sum (DMAS), which was used as a reconstruction algorithm in confocal microwave imaging for breast cancer detection, was introduced for US imaging. Consequently, DMAS was used in PA imaging systems and it was shown this algorithm results in resolution enhancement and sidelobe degrading. However, in presence of high level of noise the reconstructed image still suffers from high contribution of noise. In this paper, a modified version of DMAS beamforming algorithm is proposed based on DAS inside DMAS formula expansion. The quantitative and qualitative results show that proposed method results in more noise reduction and resolution enhancement in expense of contrast degrading. For the simulation, two-point target, along with lateral variation in two depths of imaging are employed and it is evaluated under high level of noise in imaging medium. Proposed algorithm in compare to DMAS, results in reduction of lateral valley for about 19 dB followed by more distinguished two-point target. Moreover, levels of sidelobe are reduced for about 25 dB.Comment: This paper was accepted and presented at Iranian Conference on Electrical Engineering (ICEE) 201

Eigenspace-Based Minimum Variance Combined with Delay Multiply and Sum Beamformer: Application to Linear-Array Photoacoustic Imaging

In Photoacoustic imaging, Delay-and-Sum (DAS) algorithm is the most commonly used beamformer. However, it leads to a low resolution and high level of sidelobes. Delay-Multiply-and-Sum (DMAS) was introduced to provide lower sidelobes compared to DAS. In this paper, to improve the resolution and sidelobes of DMAS, a novel beamformer is introduced using Eigenspace-Based Minimum Variance (EIBMV) method combined with DMAS, namely EIBMV-DMAS. It is shown that expanding the DMAS algebra leads to several terms which can be interpreted as DAS. Using the EIBMV adaptive beamforming instead of the existing DAS (inside the DMAS algebra expansion) is proposed to improve the image quality. EIBMV-DMAS is evaluated numerically and experimentally. It is shown that EIBMV-DMAS outperforms DAS, DMAS and EIBMV in terms of resolution and sidelobes. In particular, at the depth of 11 mm of the experimental images, EIBMV-DMAS results in about 113 dB and 50 dB sidelobe reduction, compared to DMAS and EIBMV, respectively. At the depth of 7 mm, for the experimental images, the quantitative results indicate that EIBMV-DMAS leads to improvement in Signal-to-Noise Ratio (SNR) of about 75% and 34%, compared to DMAS and EIBMV, respectively.Comment: arXiv admin note: substantial text overlap with arXiv:1709.0796

Photoacoustic Imaging using Combination of Eigenspace-Based Minimum Variance and Delay-Multiply-and-Sum Beamformers: Simulation Study

Delay and Sum (DAS), as the most common beamforming algorithm in Photoacoustic Imaging (PAI), having a simple implementation, results in a low-quality image. Delay Multiply and Sum (DMAS) was introduced to improve the quality of the reconstructed images using DAS. However, the resolution improvement is now well enough compared to high resolution adaptive reconstruction methods such as Eigenspace- Based Minimum Variance (EIBMV). We proposed to integrate the EIBMV inside the DMAS formula by replacing the existing DAS algebra inside the expansion of DMAS, called EIBMV-DMAS. It is shown that EIBMV-DMAS outperforms DMAS in the terms of levels of sidelobes and width of mainlobe significantly. For instance, at the depth of 35 mm, EIBMV-DMAS outperforms DMAS and EIBMV in the term of sidelobes for about 108 dB, 98 dB and 44 dB compared to DAS, DMAS, and EIBMV, respectively. The quantitative comparison has been conducted using Full-Width-Half-Maximum (FWHM) and Signal-to-Noise Ratio (SNR), and it was shown that EIBMV-DMAS reduces the FWHM about 1.65 mm and improves the SNR about 15 dB, compared to DMAS.Comment: Submitted in 24th Iranian Conference on Biomedical Engineering (ICBME 2017