6,841 research outputs found

    Locked out, but not disconnected: multilingual community engagement in Australia

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    At the onset of COVID-19, many Local Government Areas (LGAs) indicated they were struggling to communicate effectively with multilingual migrant communities. Communities were isolated from vital LGA support due to factors including the digital divide, barriers to language access, and top-down communication strategies. The pandemic also provided insights into the ways migrant communities mitigate hardship by engaging in placemaking and place-shaping, using existing networks and resources to provide vital support during crisis, which requires significant invisible labour. In this article, we present three case studies from a larger community-based project which began in early 2020 with an LGA in Western Australia. We use case narratives to illustrate and analyse three common actions migrant women used to engage their communities prior to, and during, COVID-19 recovery. These simple, yet profound actions, which include visiting communities, acknowledging challenges, and identifying opportunities further evidence the ways community leaders facilitate culturally sustaining placemaking, even during crisis; they underscore the intense emotional, cultural, and linguistic labour required to enact support in contexts where resources are inaccessible or misaligned with community stories. We argue it is only in partnership with communities that LGAs can learn to address some of the long-standing issues COVID-19 highlights

    An inversely designed mode-multiplexed photonic integrated vector dot-product core

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    Photonic computing has the potential of harnessing the full degrees of freedom (DOFs) of the light field, including wavelength, spatial mode, spatial location, phase quadrature, and polarization, to achieve higher level of computation parallelization and scalability than digital electronic processors. While multiplexing using wavelength and other DOFs can be readily integrated on silicon photonics platforms with compact footprints, conventional mode-division multiplexed (MDM) photonic designs occupy areas exceeding tens to hundreds of microns for a few spatial modes, significantly limiting their scalability. Here we utilize inverse design to demonstrate an ultracompact photonic computing core that calculates vector dot-products based on MDM coherent mixing within a nominal footprint of 5 um x 3 um. Our dot-product core integrates the functionalities of 2 mode multiplexers and 1 multi-mode coherent mixers, all within the footprint, and could be applied to various computation and computer vision tasks, with high computing throughput density. We experimentally demonstrate computing examples on the fabricated core, including complex number multiplication and motion estimation using optical flow

    Supplement Number 1

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    Supplemental Information document containing additional implant details, a furnace schematic, a discussion of the importance of purge times, results of annealing Ga2O3 in forming gas, contact resistance analysis, additional XRD plots, and additional STEM images

    FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice

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    Fibroblast growth factor 21 (FGF21) is a glucose and lipid metabolic regulator. Recent research revealed that FGF21 was also induced by inflammatory stimuli. Its role in inflammatory bowel disease (IBD) has not been investigated. In this study, an experimental IBD model was established in FGF21 knockout (KO) and wild-type (WT) mice by adding 2.5% (wt/vol) dextran sodium sulfate (DSS) to their drinking water for 7 days. The severity of the colitis and the inflammation of the mouse colon tissues were analyzed. In WT mice, acute DSS treatment induced an elevation in plasma FGF21 and a significant loss of body weight in a time-dependent manner. Surprisingly, the loss of body weight and the severity of the colitis induced by DSS treatment in WT mice were significantly attenuated in FGF21 KO mice. Colon and circulating pro-inflammatory factors were significantly lower in the FGF21 KO mice compared to the WT mice. As shown by BrdU staining, the FGF21 KO mice demonstrated increased colonic epithelial cell proliferation. DSS treatment reduced intestinal Paneth cell and goblet cell numbers in the WT mice, and this effect was attenuated in the FGF21 KO mice. Mechanistically, FGF21 deficiency significantly increased the signal transducer and activator of transcription (STAT)-3 activation in intestinal epithelial cells and increased the expression of IL-22. Further study showed that the expression of suppressor of cytokine signaling-2/3 (SOCS 2/3), a known feedback inhibitor of STAT3, was significantly inhibited in the DSS-treated FGF2 KO mice compared to the WT mice. We conclude that FGF21 deficiency attenuated the severity of DSS-induced acute colitis, which is likely mediated by enhancing the activation of the IL-22-STAT3 signaling pathway in intestinal epithelial cells

    Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study

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    in this study we aimed to characterize the type and prevalence of neurological symptoms related to neurological long-COVID-19 from a large international multicenter cohort of adults after discharge from hospital for acute COVID-19

    Small vessel childhood primary angiitis of the central nervous system with positive anti-glial fibrillary acidic protein antibodies: a case report and review of literature

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    Abstract Background Small vessel childhood primary angiitis of the central nervous system (SV-cPACNS) is a rare disease characterized by inflammation within small vessels such as arterioles or capillaries. Case presentation We report a case of SV-cPACNS in an 8-year-old boy confirmed by brain biopsy. This patient was also incidentally found to have anti-glial fibrillary acidic protein (GFAP) antibodies in the cerebrospinal fluid (CSF) but had no evidence of antibody-mediated disease on brain biopsy. A literature review highlighted the rarity of SV-cPACNS and found no prior reports of CSF GFAP-associated SV-cPACNS in the pediatric age group. Conclusion We present the first case of biopsy proven SV-cPACNS vasculitis associated with an incidental finding of CSF GFAP antibodies. The GFAP antibodies are likely a clinically insignificant bystander in this case and possibly in other diseases with CNS inflammation. Further research is needed to determine the clinical significance of newer CSF autoantibodies such as anti-GFAP before they are used for medical decision-making in pediatrics

    Brooks County Hospital, Felfurrios, Texas (Back)

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    1 picture postcard, see more at https://archives.library.tmc.edu/ic091-flat-01.https://digitalcommons.library.tmc.edu/txhealthfacpostc/1595/thumbnail.jp