6 research outputs found
Vein graft surveillance: is graft revision without angiography justified and what criteria should be used?
Vein graft surveillance: is graft revision without angiography justified and what criteria should be used?
Vein graft surveillance: is graft revision without angiography justified and what criteria should be used?
Economising vein-graft surveillance programs
Objectives:To investigate the effectiveness of two alternative vein-graft surveillance strategies. In the first strategy surveillance was restricted to patients with a possible higher risk of significant stenosis development, i.e. those with a moderate stenosis identified early after the operation. In the second strategy the effects of reducing the number of duplex tests per patient was examined.Patients and Methods:In a prospective study in three vascular surgical departments 300 patients (300 femoropopliteal or distal grafts) underwent duplex surveillance during the first year after the operation. The duplex-derived PSV-ratio was considered to represent the degree of stenosis. Arteriographic confirmation of suspected stenoses was routinely obtained, and patients without a suspected graft stenosis underwent a consented arteriogram during the first postoperative year. The decision to perform a graft revision was taken on the basis of an arteriographic stenosis of at least 70% diameter reduction. In the first strategy graft categories were defined on the basis of the first postoperative duplex examination: grafts with a PSV-ratio <1.5, grafts with a PSV-ratio <1.5–2.0, grafts with a PSV-ratio of 2.0–2.5, grafts with PSV-ratios 2.5–3.0, and grafts with PSV-ratios >3.0. The primary patency rate at 12 months was compared for these categories. In the second alternative strategy the number of examinations and the percentage of event causing de novo stenoses were analysed per surveillance interval.Results:The presence of moderate abnormalities at the initial duplex scan did not identify patients with a high risk of an event, as initial PSV-ratios of 1.5–2.0 and 2.0–2.5 (early mild-moderate lesions) had comparable 12-month primary patencies to patients with a PSV-ratio <1.5 (completely normal grafts): (63%, 73%, and 71%, respectively). The interval incidence of event causing de novo stenoses was 8% of the total number of duplex tests performed at 3 months, and 8% at 6 months after the operation. In patients who had no previous intervention for stenosis and had a normal bypass during the first 6 months postoperatively, a sharp drop in this incidence was seen at 9 and 12 months, with event causing de novo stenoses observed in only 2% and 1% of all duplex tests.Conclusions:All patients should be included in a surveillance program, as the presence of a normal vein graft at the first duplex examination does not rule out the subsequent development of graft stenosis. The duration of the surveillance period may be restricted to the first 6 months after operation in patients who have a normal bypass during that time period, as only few stenoses will be missed by this policy
Factors influencing the development of vein-graft stenosis and their significance for clinical management
AbstractObjectivesto assess the influence of clinical and graft factors on the development of stenotic lesions. In addition the implications of any significant correlation for duplex surveillance schedules or surgical bypass techniques was examined.Patients and methodsin a prospective three centre study, preoperative and peroperative data on 300 infrainguinal autologous vein grafts was analysed. All grafts were monitored by a strict duplex surveillance program and all received an angiogram in the first postoperative year. A revision was only performed if there was evidence of a stenosis of 70% diameter reduction or greater on the angiogram.Resultsthe minimum graft diameter was the only factor correlated significantly with the development of asignificant graft stenosis(PSV-ratio ≥2.5) during follow-up (p=0.002). Factors that correlated with the development ofevent-causing graft stenosis, associated with revision or occlusion, were minimal graft diameter (p=0.001), the use of a venovenous anastomosis (p=0.005) and length of the graft (p=0.025). Multivariate regression analysis revealed that the minimal graft diameter was the only independent factor that significantly correlated with anevent-causing graft stenosis(p=0.009). The stenosis-free rates for grafts with a minimal diameter <3.5 mm, between 3.5–4.5 and ≥4.5 mm were 40%, 58% and 75%, respectively (p=<0.05). Composite vein and arm-vein grafts with minimal diameters ≥3.5 mm were compared with grafts which consisted of a single uninterrupted greater saphenous vein with a minimal diameter of <3.5 mm. One-year secondary patency rates in these categories were of 94% and 76%, respectively (p=0.03).Conclusionsa minimal graft diameter <3.5 mm was the only factor that significantly correlated with the development of a graft-stenosis. However, veins with larger diameters may still develop stenotic lesions. Composite vein and arm-vein grafts should be used rather than uninterrupted small caliber saphenous veins