A Translucent Nodule of the Nipple in an Elderly Male Patient.

OBSERVATION. A male patient in his 70s presented an asymptomatic, slightly eroded, translucent nodule on his right nipple (Figure 1). There was a family history of cutaneous melanoma in his two sisters, daughter, and nephew; breast cancer in his mother and sister. There were no detected genetic mutations in family members’ serum to predispose them to melanoma skin cancer or breast cancer. The main genes tested were the following: BRCA1, BRCA2, PALB2, CHEK2 and TP53. Dermoscopy showed a translucent lesion with arborizing vessels and erosion (Figure 2). A punch biopsy was performed. [...

Liposarcoma of the Arygepiglottic Fold: Teaching point: A mosaic tumor pattern mixing fatty and non-fatty enhancing components suggests liposarcoma, even in very rare locations such as neck spaces.

Liposarcoma of the larynx and hypopharynx is very rare. Computed tomography (CT) and magnetic resonance imaging (MRI) examinations may synergistically disclose suggestive features of a fat-containing tumor with non-fatty enhancing sub-areas. Diagnosis relies on histological examination of a biopsic specimen. This rare pathology should ultimately be kept in mind when dealing with an laryngeal/hypopharyngeal mass

Fine needle aspiration cytology of the breast: Impact of experience on accuracy, using standardized cytologic criteria

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Actinomycosis and osteonecrosis of the jaw : every why hides a why

Actinomycosis and osteonecrosis of the jaw : every why hides a wh

Lassueur-Graham Little-Piccardi syndrome: a 20-year follow-up.

Lassueur-Graham Little-Piccardi (LGLP) syndrome is a distinctive entity associating a scarring patchy alopecia of the scalp, a non-cicatricial axillary and pubic hair loss and a lichenoid follicular eruption. We present a 20-year follow-up of a demonstrative case, which had begun as typical lichen planus. In the literature, the relationship with lichen planus remains unclear. The diagnosis of LGLP syndrome should be evoked for all scarring alopecias

Actinomycosis and osteonecrosis of the jaw: Every why hides a why

Osteonecrosis of the jaws (ONJ) is a chronic and challenging disease for most clinicians. Two types of ONJ are described with different etiologies and pathophysiological mechanisms: osteoradionecrosis (ORN) and Medication-Related Osteonecrosis of the Jaws (MRONJ). Actinomyces is a Gram positive, filamentous, facultative and anaerobic bacteria that exists in the normal flora of oral cavity, gastrointestinal tract and female genital tract. It belongs to Actinomycetaceae, Propionibacteriaceae and Bifidobacteriacea species with Actinomyces israelii, Actinomyces rencseriae and Actinomyces naeslundii / viscosus representing more than 75% of them. However, the most common agent found into the oral cavity is Actinomyces israelii. Actinomyces infection causes on the head and neck region a suppurative and granulomatous infectious reaction with abscess formation, tissue fibrosis, and occasionally a soft tissue tumor-like mass. It usually follows a dental disease or a jaw osteomyelitis commonly called the “lumpy jaw syndrome

Not All Cases of Mammary Paget's Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!

Mammary Paget's disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resulted in an initial misdiagnosis and, subsequently, a delay in the patient's follow-up. Additional immunohistochemistry for GATA binding protein 3 (GATA3) and human epidermal growth factor receptor 2 (HER2), as well as a second opinion of a breast pathologist, resulted in the diagnosis of mammary Paget's disease. The aim of this article is to raise awareness among pathologists and prevent them from misdiagnosing CK7-negative Paget disease of the breast