Het taalniveau van kinderen met primaire taalontwikkelingsstoornissen

Dit artikel betreft de vraag of kinderen met een primaire taalontwikkelingsstoornis gekenmerkt worden door een receptief-expressieve, dan wel een expressieve taalontwikkelingsstoornis. Om deze onderzoeksvraag te kunnen beantwoorden werden de Reynell Test voor Taalbegrip en de Schlichting Test voor Taalproduktie bij een groep kinderen met primaire taalontwikkelingsstoornissen afgenomen (N = 41). De scores van de kinderen met taalontwikkelingsstoornissen (TOS) werden door middel van matching op leeftijd, geslacht en sociaal-economische status vergeleken met die van kinderen uit een voor de Nederlandse populatie representatieve steekproef (de ijkingssteekproef (IJK) van beide tests). De voornaamste resultaten zijn dat de TOS-groep bij alle onderdelen van taalbegrip en -produktie significant lager scoorde dan de IJK-groep. Het grootste verschil kwam voor bij de produktietest Zinsontwikkeling; het kleinste verschil bij de taalbegripstest. Het intelligentieniveau van beide groepen bleek niet significant te verschillen

Ketogenic diet for epilepsy and obesity:Is it the same?

The term “ketogenic diet” (KD) is used for a wide variety of diets with diverse indications ranging from obesity to neurological diseases, as if it was the same diet. This terminology is confusing for patients and the medical and scientific community. The term “ketogenic” diet implies a dietary regimen characterized by increased levels of circulating ketone bodies that should be measured in blood (beta-hydroxybutyrate), urine (acetoacetate) or breath (acetone) to verify the “ketogenic metabolic condition”. Our viewpoint highlights that KDs used for epilepsy and obesity are not the same; the protocols aimed at weight loss characterized by low-fat, low-CHO and moderate/high protein content are not ketogenic by themselves but may become mildly ketogenic when high calorie restriction is applied. In contrast, there are standardized protocols for neurological diseases treatment for which ketosis has been established to be part of the mechanism of action. Therefore, in our opinion, the term ketogenic dietary therapy (KDT) should be reserved to the protocols considered for epilepsy and other neurological diseases, as suggested by the International Study Group in 2018. We propose to adjust the abbreviations in VLCHKD for Very Low CarboHydrate Ketogenic Diet and VLEKD for Very Low Energy Ketogenic Diet, to clarify the differences in dietary composition. We recommend that investigators describe the researchers describing efficacy or side effects of KDs, to clearly specify the dietary protocol used with its unique acronym and level of ketosis, when ketosis is considered as a component of the diet's mechanism of action.</p

Health-related quality of life among adult HIV positive patients : assessing comprehensive themes and interrelated associations

Acknowledgements We would like to thank all HIV doctors, HIV nurses and clinical nurse specialists for their help with the inclusion of patients in the study. We are further grateful to all patients who filled out the questionnaires.Peer reviewedPublisher PD

Tunneling Between Parallel Two-Dimensional Electron Gases

The tunneling between two parallel two-dimensional electron gases has been investigated as a function of temperature $T$, carrier density $n$, and the applied perpendicular magnetic field $B$. In zero magnetic field the equilibrium resonant lineshape is Lorentzian, reflecting the Lorentzian form of the spectral functions within each layer. From the width of the tunneling resonance the lifetime of the electrons within a 2DEG has been measured as a function of $n$ and $T$, giving information about the density dependence of the electron-impurity scattering and the temperature dependence of the electron-electron scattering. In a magnetic field there is a general suppression of equilibrium tunneling for fields above $B=0.6$ T. A gap in the tunneling density of states has been measured over a wide range of magnetic fields and filling factors, and various theoretical predictions have been examined. In a strong magnetic field, when there is only one partially filled Landau level in each layer, the temperature dependence of the conductance characteristics has been modeled with a double-Gaussian spectral density.Comment: LaTeX requires REVTeX macros. Eighteen pages. Fourteen postscript figures are included. (All figures have been bitmapped to save space. The original can be requested by email from [email protected]). Accepted for publication in Phys. Rev.

Optical Spectroscopy of Active Galactic Nuclei in SA57

The cosmological evolution of X-ray-selected and optically selected Active Galactic Nuclei (AGNs) show different behaviours interpreted in terms of two different populations. The difference is evident mainly for low luminosity AGNs (LLAGNs), many of which are lost by optical photometric surveys. We are conducting a spectroscopical study of a composite sample of AGN candidates selected in SA57 following different searching techniques, to identify low luminosity AGNs and break down the sample into different classes of objects. AGN candidates were obtained through optical variability and/or X-ray emission. Of special interest are the extended variable objects, which are expected to be galaxies hosting LLAGNs. Among the 26 classified objects a fair number (9) show typical AGN spectra. 10 objects show Narrow Emission Line Galaxy spectra, and in most of them (8/10) optical variability suggests the presence of LLAGNs.Comment: 7 pages, 8 figures, to appear in A&

Reduction in Phencyclidine Induced Sensorimotor Gating Deficits in the Rat Following Increased System Xc − Activity in the Medial Prefrontal Cortex

Rationale: Aspects of schizophrenia, including deficits in sensorimotor gating, have been linked to glutamate dysfunction and/or oxidative stress in the prefrontal cortex. System xc −, a cystine–glutamate antiporter, is a poorly understood mechanism that contributes to both cellular antioxidant capacity and glutamate homeostasis. Objectives: Our goal was to determine whether increased system xc − activity within the prefrontal cortex would normalize a rodent measure of sensorimotor gating. Methods: In situ hybridization was used to map messenger RNA (mRNA) expression of xCT, the active subunit of system xc −, in the prefrontal cortex. Prepulse inhibition was used to measure sensorimotor gating; deficits in prepulse inhibition were produced using phencyclidine (0.3–3 mg/kg, sc). N-Acetylcysteine (10–100 μM) and the system xc − inhibitor (S)-4-carboxyphenylglycine (CPG, 0.5 μM) were used to increase and decrease system xc − activity, respectively. The uptake of 14C-cystine into tissue punches obtained from the prefrontal cortex was used to assay system xc − activity. Results: The expression of xCT mRNA in the prefrontal cortex was most prominent in a lateral band spanning primarily the prelimbic cortex. Although phencyclidine did not alter the uptake of 14C-cystine in prefrontal cortical tissue punches, intraprefrontal cortical infusion of N-acetylcysteine (10–100 μM) significantly reduced phencyclidine- (1.5 mg/kg, sc) induced deficits in prepulse inhibition. N-Acetylcysteine was without effect when coinfused with CPG (0.5 μM), indicating an involvement of system xc −. Conclusions: These results indicate that phencyclidine disrupts sensorimotor gating through system xc − independent mechanisms, but that increasing cystine–glutamate exchange in the prefrontal cortex is sufficient to reduce behavioral deficits produced by phencyclidine

A catalogue of the Chandra Deep Field South with multi-colour classification and photometric redshifts from COMBO-17

We present the COMBO-17 object catalogue of the Chandra Deep Field South for public use, covering a field which is 31.5' x 30' in size. This catalogue lists astrometry, photometry in 17 passbands from 350 to 930 nm, and ground-based morphological data for 63,501 objects. The catalogue also contains multi-colour classification into the categories 'Star', 'Galaxy' and 'Quasar' as well as photometric redshifts. We include restframe luminosities in Johnson, SDSS and Bessell passbands and estimated errors. The redshifts are most reliable at R<24, where the sample contains approximately 100 quasars, 1000 stars and 10000 galaxies. We use nearly 1000 spectroscopically identified objects in conjunction with detailed simulations to characterize the performance of COMBO-17. We show that the selection of quasars, more generally type-1 AGN, is nearly complete and minimally contaminated at z=[0.5,5] for luminosities above M_B=-21.7. Their photometric redshifts are accurate to roughly 5000 km/sec. Galaxy redshifts are accurate to 1% in dz/(1+z) at R<21. They degrade in quality for progressively fainter galaxies, reaching accuracies of 2% for galaxies with R~222 and of 10% for galaxies with R>24. The selection of stars is complete to R~23, and deeper for M stars. We also present an updated discussion of our classification technique with maps of survey completeness, and discuss possible failures of the statistical classification in the faint regime at R>24.Comment: submitted to Astronomy & Astrophysics, public data set available at http://www.mpia.de/COMBO/combo_index.htm

Extended Lyman alpha emission around bright quasars

Quasars trace the most massive structures at high redshifts and their presence may influence the evolution of the massive host galaxies. We study the extended Lyman alpha emission line regions (EELRs) around seven bright, mostly radio-quiet quasars (QSOs) at 2.7<z<4.5, and compare luminosities with EELRs around radio-loud QSOs reported in the literature. Using integral field spectroscopy, we analyse the morphology and kinematics of the quiescent Lya EELRs around the QSOs. We find evidence for the presence of EELRs around four radio-quiet and one radio-loud QSO. All EELRs appear asymmetric and the optically brightest QSOs also have the brightest Lya nebulae. For the two brightest nebulae we find velocities between ~600 km s^-1 at the QSO position to ~200 km s^-1 at a distance of 3-4 arcsec from the QSO and surface flux densities up to 2-3*10^{-16} erg cm^-2 s^-1 arcsec^-2. The five EELRs have total Lya luminosities which correspond to ~0.5% of the luminosities from the QSOs broad Lya emission lines. This fraction is an order of magnitude smaller than found for EELRs around radio-loud, steep spectrum QSOs reported in the literature. While the nebulae luminosities are correlated with the QSO Lya luminosities, we find that nebulae luminosities are not correlated with the central QSO ionising fluxes. The presence of gas in the EELRs can be interpreted based on two competing scenarios: either from quasar feedback mechanisms, or from infalling matter. Apart from these two effects, the Lya flux around radio-loud objects can be enhanced due to interactions with the radio jets. The relatively fainter nebulae around radio-quiet QSOs compared to lobe-dominated radio-loud QSOs can be ascribed to this effect, or to significant differences in the environments between the two classes.Comment: 15 pages, A&A accepted. Section 4 revise