5,705 research outputs found

    Supersymmetric Brane World Scenarios from Off-Shell Supergravity

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    Using N=2 off-shell supergravity in five dimensions, we supersymmetrize the brane world scenario of Randall and Sundrum. We extend their construction to include supersymmetric matter at the fixpoints.Comment: 15 pages, no figures, late

    Functional Properties of Subretinal Transplants in Rabbit

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    Reduced brain activation during inhibitory control in children with COMT Val/Val genotype

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    IntroductionBehavioral undercontrol is a well‐established risk factor for substance use disorder, identifiable at an early age well before the onset of substance use. However, the biological mechanistic structure underlying the behavioral undercontrol/substance use relationship is not well understood. The enzyme catechol O‐methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex and striatum, brain regions involved in behavioral control. The goal of this work was to investigate the association between genetic variation in COMT functioning and fronto‐striatal brain functioning during successful inhibitory control, a critical aspect of behavioral control.MethodsParticipants were 65 (22 female) 7–12 year olds who were genotyped for the functional COMT Val158Met (rs4680) single‐nucleotide polymorphism and underwent functional magnetic resonance imaging while performing a go/no‐go task. The majority of the sample (80%) had at least one parent with a history of alcohol use disorder and were thus at heightened risk for substance use disorders.ResultsThere was a significant main effect of genotype on brain activation in left and right putamen during successful versus failed inhibition and in right inferior frontal gyrus/insula during successful inhibition versus baseline. Follow‐up tests revealed that Met homozygotes had greater activation in each region relative to Val homozygotes.ConclusionsThese results are relevant for understanding how specific genes influence brain functioning related to underlying risk factors for substance use disorders and other disinhibitory psychopathologies.The goal of this work was to investigate the association between genetic variation in COMT functioning and fronto‐striatal brain functioning during inhibitory control, a critical aspect of behavioral control. Participants were 65 (22 female) 7–12 year olds who were genotyped for the functional COMT Val158Met (rs4680) single‐nucleotide polymorphism and underwent functional magnetic resonance imaging while performing a go/no‐go task. There was a significant main effect of genotype on brain activation in left and right putamen during successful versus failed inhibition and in right inferior frontal gyrus/insula during successful inhibition versus baseline; follow‐up tests revealed that Met homozygotes had greater activation in each region relative to Val homozygotes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135697/1/brb3577_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135697/2/brb3577.pd

    A Bayesian Approach to Locating the Red Giant Branch Tip Magnitude (Part I)

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    We present a new approach for identifying the Tip of the Red Giant Branch (TRGB) which, as we show, works robustly even on sparsely populated targets. Moreover, the approach is highly adaptable to the available data for the stellar population under study, with prior information readily incorporable into the algorithm. The uncertainty in the derived distances is also made tangible and easily calculable from posterior probability distributions. We provide an outline of the development of the algorithm and present the results of tests designed to characterize its capabilities and limitations. We then apply the new algorithm to three M31 satellites: Andromeda I, Andromeda II and the fainter Andromeda XXIII, using data from the Pan-Andromeda Archaeological Survey (PAndAS), and derive their distances as 731(−4)−17(+5)+18731^{(+ 5) + 18}_{(- 4) - 17} kpc, 634(−2)−14(+2)+15634^{(+ 2) + 15}_{(- 2) - 14} kpc and 733(−11)−22(+13)+23733^{(+ 13)+ 23}_{(- 11) - 22} kpc respectively, where the errors appearing in parentheses are the components intrinsic to the method, while the larger values give the errors after accounting for additional sources of error. These results agree well with the best distance determinations in the literature and provide the smallest uncertainties to date. This paper is an introduction to the workings and capabilities of our new approach in its basic form, while a follow-up paper shall make full use of the method's ability to incorporate priors and use the resulting algorithm to systematically obtain distances to all of M31's satellites identifiable in the PAndAS survey area.Comment: 11 pages, 18 figure

    A Keck/DEIMOS spectroscopic survey of faint Galactic satellites: searching for the least massive dwarf galaxies

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    [abridged] We present the results of a spectroscopic survey of the recently discovered faint Milky Way satellites Boo, UMaI, UMaII and Wil1. Using the DEIMOS spectrograph on Keck, we have obtained samples that contain from 15 to 85 probable members of these satellites for which we derive radial velocities precise to a few km/s down to i~21-22. About half of these stars are observed with a high enough S/N to estimate their metallicity to within \pm0.2 dex. From this dataset, we show that UMaII is the only object that does not show a clear radial velocity peak. However, the measured systemic radial velocity (v_r=115\pm5 km/s) is in good agreement with recent simulations in which this object is the progenitor of the recently discovered Orphan Stream. The three other satellites show velocity dispersions that make them highly dark-matter dominated systems. In particular the Willman 1 object is not a globular cluster given its metallicity scatter over -2.0<[Fe/H]<-1.0 and is therefore almost certainly a dwarf galaxy or dwarf galaxy remnant. We measure a radial velocity dispersion of only 4.3_{-1.3}^{+2.3} km/s around a systemic velocity of -12.3\pm2.3 km/s which implies a mass-to-light ratio of ~700 and a total mass of ~5x10^5 Msun for this satellite, making it the least massive satellite galaxy known to date. Such a low mass could mean that the 10^7 Msun limit that had until now never been crossed for Milky Way and Andromeda satellite galaxies may only be an observational limit and that fainter, less massive systems exist within the Local Group. However, more modeling and an extended search for potential extra-tidal stars are required to rule out the possibility that these systems have not been significantly heated by tidal interaction.Comment: 24 pages, 11 figures, MNRAS accepte

    Stability of the Higgs mass in theories with extra dimensions

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    We analyze the ultraviolet stability of the Higgs mass in recently proposed Kaluza-Klein models compactified on S_1/Z_2 or S_1/(Z_2\times Z_2'), both at the field theory and string theory level. Fayet-Iliopoulos terms of U(1) hypercharge are shown to be of vital importance for this discussion. Models with a single Higgs doublet seem to be generically affected by quadratic divergences.Comment: Contribution to the Proceedings of Durham IPPP meeting May 2001.(12 pages, LaTeX

    Adaptive thermal compensation of test masses in advanced LIGO

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    As the first generation of laser interferometric gravitational wave detectors near operation, research and development has begun on increasing the instrument's sensitivity while utilizing the existing infrastructure. In the Laser Interferometer Gravitational Wave Observatory (LIGO), significant improvements are being planned for installation in ~2007, increasing strain sensitivity through improved suspensions and test mass substrates, active seismic isolation, and higher input laser power. Even with the highest quality optics available today, however, finite absorption of laser power within transmissive optics, coupled with the tremendous amount of optical power circulating in various parts of the interferometer, result in critical wavefront deformations which would cripple the performance of the instrument. Discussed is a method of active wavefront correction via direct thermal actuation on optical elements of the interferometer. A simple nichrome heating element suspended off the face of an affected optic will, through radiative heating, remove the gross axisymmetric part of the original thermal distortion. A scanning heating laser will then be used to remove any remaining non-axisymmetric wavefront distortion, generated by inhomogeneities in the substrate's absorption, thermal conductivity, etc. A proof-of-principle experiment has been constructed at MIT, selected data of which are presented.Comment: 11 pages, 7 figures, submitted to Classical and Quantum Gravit

    Histomorphometric Analysis of the Rat Proximal Tibial Metaphysis by “Linear Scanning”

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    Twenty-four female Sprague-Dawley rats (10 weeks old, 200g BW) were either sham-operated (n = 6) or ovariectomized (ovx). Ovx rats were divided into 3 groups (n = 6 each) : ovx; ovx + 1,25(OH) 2D3; ovx + l,25(OH)2D3 + 1,24,25(OH)3D3. The vitamin D metabolites were fed orally starting the day after surgery. After 7 weeks all rats were sacrificed and the proximal tibiae were processed undecalcified for quantitative histomorphometry. Conventional histomorphometric analysis of the distal zone (\u3e 1 mm from the growth cartilage) of the tibial metaphysis revealed a dramatic loss of cancellous bone mass in ovx rats. Both l,25(OH)2D3 and the combination of l,25(OH)2D3 with l,24,25(OH)3D3 prevented the bone loss in the distal zone in ovx animals. Measurements in the proximal zone (\u3c 1 mm from the growth cartilage) of the tibial metaphysis were performed with a newly developed technique that utilizes the advantages of automatic image analysis, and that we propose to name linear scanning . This method revealed a significantly decreased hard tissue mass at about 100 ÎŒm and within 800 to 950 ÎŒm distance from the growth plate in ovx rats. However, ovx rats reached normal amounts of hard tissue within 250 to 450 ÎŒm from the growth plate. The results obtained by linear scanning suggest that the obvious loss of cancellous bone mass in the distal zone of the tibial metaphysis in growing ovx rats is not a consequence of structural changes in the proximal zone

    Universal contributions to scalar masses from five dimensional supergravity

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    We compute the effective Kahler potential for matter fields in warped compactifications, starting from five dimensional gauged supergravity, as a function of the matter fields localization. We show that truncation to zero modes is inconsistent and the tree-level exchange of the massive gravitational multiplet is needed for consistency of the four-dimensional theory. In addition to the standard Kahler coming from dimensional reduction, we find the quartic correction coming from integrating out the gravity multiplet. We apply our result to the computation of scalar masses, by assuming that the SUSY breaking field is a bulk hypermultiplet. In the limit of extreme opposite localization of the matter and the spurion fields, we find zero scalar masses, consistent with sequestering arguments. Surprisingly enough, for all the other cases the scalar masses are tachyonic. This suggests the holographic interpretation that a CFT sector always generates operators contributing in a tachyonic way to scalar masses. Viability of warped su- persymmetric compactifications necessarily asks then for additional contributions. We discuss the case of additional bulk vector multiplets with mixed boundary conditions, which is a partic- ularly simple and attractive way to generate large positive scalar masses. We show that in this case successful fermion mass matrices implies highly degenerate scalar masses for the first two generations of squarks and sleptons.Comment: 23 pages. v2: References added, new section on effect of additional bulk vector multiplets and phenomenolog

    Ultracompact, low-loss directional couplers on InP based on self-imaging by multimode interference

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    We report extremely compact (494-”m-long 3 dB splitters, including input/output bends), polarization-insensitive, zero-gap directional couplers on InP with a highly multimode interference region that are based on the self-imaging effect. We measured cross-state extinctions better than 28 dB and on-chip insertion losses of 0.5 dB/coupler plus 1 dB/cm guide propagation loss at 1523 nm wavelength
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