Semi-Supervised Learning for Neural Machine Translation

While end-to-end neural machine translation (NMT) has made remarkable progress recently, NMT systems only rely on parallel corpora for parameter estimation. Since parallel corpora are usually limited in quantity, quality, and coverage, especially for low-resource languages, it is appealing to exploit monolingual corpora to improve NMT. We propose a semi-supervised approach for training NMT models on the concatenation of labeled (parallel corpora) and unlabeled (monolingual corpora) data. The central idea is to reconstruct the monolingual corpora using an autoencoder, in which the source-to-target and target-to-source translation models serve as the encoder and decoder, respectively. Our approach can not only exploit the monolingual corpora of the target language, but also of the source language. Experiments on the Chinese-English dataset show that our approach achieves significant improvements over state-of-the-art SMT and NMT systems.Comment: Corrected a typ

[N′-(3-Meth­oxy-2-oxidobenzyl­idene)nicotinohydrazidato]diphenyl­tin(IV)

The asymmetric unit of the title compound, [Sn(C6H5)2(C14H11N3O3)], contains two crystallographically independent mol­ecules that differ predominantly in the torsion of the phenyl rings. In both mol­ecules, the SnIV ion is in a distored trigonal-bipyramidal geometry. The Sn—O distances are in the range 2.055 (2)–2.143 (2) Å

Regional remodeling strain and its association with myocardial apoptosis after myocardial infarction in an ovine model

ObjectiveProgressive left ventricular remodeling after myocardial infarction has been viewed as an important contributor to progressive heart failure. The objective of this study was to investigate the relationship between myocardial apoptosis and strain during progressive cardiac remodeling.MethodsBefore creation of an anterolateral left ventricular infarction by ligation of diagonal arteries, 16 sonomicrometry transducers were placed in the left ventricular free wall of 8 sheep to assess regional deformation in the infarct, adjacent, and normally perfused remote myocardial regions over 8 weeks' duration. Hemodynamic, echocardiographic and sonomicrometric data were collected before infarction and then 30 minutes and 2, 6, and 8 weeks after infarction. At the end of the study, regional myocardial tissues were collected for apoptotic signaling proteins.ResultsAt terminal study, an increase in left ventricular end-diastolic pressure of 8.1 ± 0.1 mm Hg, a decrease in ejection fraction from 54.19% ± 5.68% to 30.55% ± 2.72%, and an end-diastolic volume increase of 46.08 ± 5.02 mL as compared with the preinfarct values were observed. The fractional contraction at terminal study correlated with the relative abundance of apoptotic protein expressions: cytochrome c (r2 = 0.02, P < .05), mitochondrial Bax (r2 = 0.27, P < .05), caspase-3 (r2 = 0.31, P < .05), and poly (adenosine diphosphate–ribose) polymerase (r2 = 0.30, P < .05). These myocardial apoptotic activities also correlated with remodeling strain: cytochrome c (r2 = 0.02, P < .05), mitochondrial Bax (r2 = 0.28, P < .05), caspase-3 (r2 = 0.43, P < .05), and poly (adenosine diphosphate–ribose) polymerase (r2 = 0.37, P < .05).ConclusionIncrease in regional remodeling strain led to an increase in myocardial apoptosis and regional contractile dysfunction in heart failure

Components of the Hematopoietic Compartments in Tumor Stroma and Tumor-Bearing Mice

Solid tumors are composed of cancerous cells and non-cancerous stroma. A better understanding of the tumor stroma could lead to new therapeutic applications. However, the exact compositions and functions of the tumor stroma are still largely unknown. Here, using a Lewis lung carcinoma implantation mouse model, we examined the hematopoietic compartments in tumor stroma and tumor-bearing mice. Different lineages of differentiated hematopoietic cells existed in tumor stroma with the percentage of myeloid cells increasing and the percentage of lymphoid and erythroid cells decreasing over time. Using bone marrow reconstitution analysis, we showed that the tumor stroma also contained functional hematopoietic stem cells. All hematopoietic cells in the tumor stroma originated from bone marrow. In the bone marrow and peripheral blood of tumor-bearing mice, myeloid populations increased and lymphoid and erythroid populations decreased and numbers of hematopoietic stem cells markedly increased with time. To investigate the function of hematopoietic cells in tumor stroma, we co-implanted various types of hematopoietic cells with cancer cells. We found that total hematopoietic cells in the tumor stroma promoted tumor development. Furthermore, the growth of the primary implanted Lewis lung carcinomas and their metastasis were significantly decreased in mice reconstituted with IGF type I receptor-deficient hematopoietic stem cells, indicating that IGF signaling in the hematopoietic tumor stroma supports tumor outgrowth. These results reveal that hematopoietic cells in the tumor stroma regulate tumor development and that tumor progression significantly alters the host hematopoietic compartment

Comprehensive analysis of the association between inflammation indexes and complications in patients undergoing pancreaticoduodenectomy

BackgroundDuring clinical practice, routine blood tests are commonly performed following pancreaticoduodenectomy (PD). However, the relationship between blood cell counts, inflammation-related indices, and postoperative complications remains unclear.MethodWe conducted a retrospective study, including patients who underwent PD from October 2018 to July 2023 at the First Hospital of Chongqing Medical University, and compared baseline characteristics and clinical outcomes among different groups. Neutrophil count (NC), platelet count (PLT), lymphocyte count (LC), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and the product of platelet count and neutrophil count (PPN) were derived from postoperative blood test results. We investigated the association between these indicators and outcomes using multivariable logistic regression and restricted cubic spline analysis. The predictive performance of these indicators was assessed by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and decision curve analysis (DCA).ResultA total of 232 patients were included in this study. Multivariate logistic regression and restricted cubic spline analysis showed that all indicators, except for PLT, were associated with clinical postoperative pancreatic fistula (POPF). SII, NLR, and NC were linked to surgical site infection (SSI), while SII, NLR, and PLR were correlated with CD3 complication. PLT levels were related to postoperative hemorrhage. SII (AUC: 0.729), NLR (AUC: 0.713), and NC (AUC: 0.706) effectively predicted clinical POPF.ConclusionIn patients undergoing PD, postoperative inflammation-related indices and blood cell counts are associated with various complications. NLR and PLT can serve as primary indicators post-surgery for monitoring complications

A high gain, noise cancelling 2515-4900 MHz CMOS LNA for China mobile 5G communication application

© 2020 Tech Science Press. All rights reserved. With the development of the times, people\u27s requirements for communication technology are becoming higher and higher. 4G communication technology has been unable to meet development needs, and 5G communication technology has emerged as the times require. This article proposes the design of a low-noise amplifier (LNA) that will be used in the 5G band of China Mobile Communications. A low noise amplifier for mobile 5G communication is designed based on Taiwan Semiconductor Manufacturing Company (TSMC) 0.13 μm Radio Frequency (RF) Complementary Metal Oxide Semiconductor (CMOS) process. The LNA employs self-cascode devices in current-reuse configuration to enable lower supply voltage operation without compromising the gain. This design uses an active feedback amplifier to achieve input impedance matching, avoiding the introduction of resistive negative feedback to reduce gain. A common source (CS) amplifier is used as the input of the low noise amplifier. In order to achieve the low power consumption of LNA, current reuse technology is used to reduce power consumption. Noise cancellation techniques are used to eliminate noise. The simulation results in a maximum power gain of 22.783, the reverse isolation (S12) less than -48.092 dB, noise figure (NF) less than 1.878 dB, minimum noise figure (NFmin)=1.203 dB, input return loss (S11) and output return loss (S22) are both less than -14.933 dB in the frequency range of 2515-4900 MHz. The proposed Ultra-wideband (UWB) LNA consumed 1.424 mW without buffer from a 1.2 V power supply

Crystal structure of human μ-crystallin complexed with NADPH

Human cytosolic 3,5,3′-triiodo-L-thyronine-binding protein, also called μ-crystallin or CRYM, plays important physiological roles in transporting 3,5,3′-triiodo-L-thyronine (T3) into nuclei and regulating thyroid-hormone-related gene expression. The crystal structure of human CRYM's bacterial homolog Pseudomonas putida ornithine cyclodeaminase and Archaeoglobus fulgidus alanine dehydrogenase have been available, but no CRYM structure has been reported. Here, we report the crystal structure of human CRYM bound with NADPH refined to 2.6 Å, and there is one dimer in the asymmetric unit. The structure contains two domains: a Rossmann fold–like NADPH-binding domain and a dimerization domain. Different conformations of the loop Arg83–His92 have been observed in two monomers of human CRYM in the same asymmetric unit. The peptide bond of Val89–Pro90 is a trans-configuration in one monomer but a cis-configuration in the other. A detailed comparison of the human μ-crystallin structure with its structurally characterized homologs including the overall comparison and superposition of active sites was conducted. Finally, a putative T3-binding site in human CRYM is proposed based on comparison with structural homologs