Small-molecule Nucleic-acid-based Gene-silencing Strategies

Gene-targeting strategies based on nucleic acid have opened a new era with the development of potent and effective gene intervention strategies, such as DNAzymes, ribozymes, small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), aptamers, decoys, etc. These technologies have been examined in the setting of clinical trials, and several have recently made the successful transition from basic research to clinical trials. This chapter discusses progress made in these technologies, mainly focusing on Dzs and siRNAs, because these are poised to play an integral role in antigene therapies in the future

Heat transfer in conduction Report on Heat Sink Design

The purpose of the project is to design a heat sink with limited information given and make sure it reaches certain requirements. Design and optimization process will be done in the beginning, 2-D analytical, and 2-D numerical solution will be generated and used to check the result. Also, a fl ow simulation will be made by using SOLIDWORKS. In the end, result will be compared, diff erent between each result will be analyzed