Effect of Rice Fissure on Taste Quality of Cooked Rice

According to the change of texture attribute of cooked-rice under different fissure rate of rice, the relationship between fissure rate of rice and taste value of cooked rice were studied using correlation analysis and path analysis methods. The data of correlation analysis showed that the influence of texture attribute was significant on taste. Fissure rate had an effect on taste through hardness, gumminess, chewiness, and springiness. The data of path analysis suggested that the direct effect of gumminess was significant on taste, and the other indicators of texture attribute had indirect effect through gumminess. A regression model was constructed based on the indicators viz fissure rate, texture attributes

An Exposome Atlas of Serum Reveals the Risk of Chronic Diseases in the Chinese Population

Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, and some of them exceed safe ranges. Multi-exposure models reveal significant risk effects of exposure on hyperlipidemia, metabolic syndrome and hyperuricemia. Overall, this study provides a comprehensive human serum exposome atlas and disease risk information, which can guide subsequent in-depth cause-and-effect studies between environmental exposures and human health

Statistical Study on the Sources of Jovian Decametric Radio Emissions Based on the Radio Observations of Remote Instruments

To better understand the physical processes associated with Jovian decametric (DAM) radio emissions, we present the statistical study of DAMs and inferred characteristics of DAM sources based on multi-view observation from Wind and STEREO spacecraft. The distribution of the apparent rotation speed of DAMs derived from multiple spacecraft suggests that the rotation speed of Io-related DAMs is in range of 0.15-0.6{\Omega}_J and that of non-Io-DAMs is between 0.7-1.2{\Omega}_J. Based on the method of Wang et al. (2020), we locate the sources of the DAMs and infer their emission angles and associated electron energies. The statistical results show that the DAM source locations have three preferred regions, two in the southern hemisphere and one in the northern hemisphere, which is probably caused by the non-symmetrical topology of Jupiter's magnetic field. The difference between Io-DAM source footprints and Io auroral spots changes with the Io's position in longitude, consistent with the previous results from Hess et al. (2010), Bonfond et al. (2017) and Hinton et al. (2019). In addition, the emission angles for non-Io-DAMs are smaller than that for Io-DAMs from the same source regions and all the emission angles range from 60{\deg} to 85{\deg}. Correspondingly, the electron energy is mainly distributed between 0.5 and 20 keV.Comment: 35 pages, 16 figures, 2 table

An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker

Abstract Background The gene TIMELESS, which is involved in the circadian clock and the cell cycle, has recently been linked to various human cancers. Nevertheless, the association between TIMELESS expression and the prognosis of individuals afflicted with pan-cancer remains largely unknown. Objectives The present study aims to exhaustively scrutinize the expression patterns, functional attributes, prognostic implications, and immunological contributions of TIMELESS across diverse types of human cancer. Methods The expression of TIMELESS in normal and malignant tissues was examined, as well as their clinicopathologic and survival data. The characteristics of genetic alteration and molecular subtypes of cancers were also investigated. In addition, the relationship of TIMELESS with immune infiltration, tumor mutation burden (TMB), microsatellite instability (MSI), and drug sensitivity was illustrated. Immunohistochemistry (IHC) was used to validate the expression of TIMELESS in clinical patients with several types of cancer. Results In contrast to the matching normal controls, most tumor types were found to often overexpress TIMELESS. Abnormal expression of TIMELESS was significantly related to more advanced tumor stage and poorer prognosis of breast cancer, as well as infiltrating immune cells such as cancer-associated fibroblast infiltration in various tumors. Multiple cancer types exhibited abnormal expression of TIMELESS, which was also highly correlated with MSI and TMB. More crucially, TIMELESS showed promise in predicting the effectiveness of immunotherapy and medication sensitivity in cancer therapy. Moreover, cell cycle, DNA replication, circadian rhythm, and mismatch repair were involved in the functional mechanisms of TIMELESS on carcinogenesis. Furthermore, immunohistochemical results manifested that the TIMELESS expression was abnormal in some cancers. Conclusions This study provides new insights into the link between the circadian gene TIMELESS and the development of various malignant tumors. The findings suggest that TIMELESS could be a prospective prognostic and immunological biomarker for pan-cancer