Obesity as unfavorable background of asthma

Asthma accompanied by increased of content of proinflam- matory cytokines TNF-α (2.6 fold) and IL-6 of (1.4 times), while the comor- bidity of asthma and obesity worsens the revealed violations (an increase of 3.7 and 1.9 times, respectively), which can be considered as a negative factor supporting the inflammatory process in bronchopulmonary system

Calcium homeostasis changes in patients with chronic colitis and arterial hypertension

In patients with chronic colitis and hypertension observed negative dynamics of calcium homeostasis. It is therefore appropriate to include calcium in the complex treatment of drugs for the prevention or correction osteopenic conditions and osteoporosis

Nonalcoholic Fatty Liver Disease and Arterial Hypertension: Pathogenetic Factors of Formation and Progression

A combination of the most common and socially significant diseases of internal organs, such as arterial hypertension (AH) and nonalcoholic fatty liver disease (NAFLD), may lead to changes in the pathogenetic links of diseases. In this case, the purpose of the work was to determine the mechanisms of formation and progression of AH in patients with NAFLD. The work included 36 patients with concomitant AH and NAFLD and 21 patients with isolated AH. We determined the content of interleukins-1, -2, -4, -6 and -8, circulating immune complexes, the sum of the complement system and the level of the autosensibilization of lymphocytes to self antigens. It is found that the combination of AH and NAFLD leads to changes in the immunological spectrum of blood, which is characterized by an increase in the parameters of inflammatory process (proinflammatory cytokines, the total value of the complement system), resulting in the formation of steatohepatitis. Thus, in the combination of AH and NAFLD there are prerequisites for progression of the pathological process, with the heart, kidneys and liver as a target organs