Evolution of the Radio Remnant of Supernova 1987A: Morphological Changes from Day 7000

We present radio imaging observations of supernova remnant 1987A at 9 GHz, taken with the Australia Telescope Compact Array over 21 years from 1992 to 2013. By employing a Fourier modeling technique to fit the visibility data, we show that the remnant structure has evolved significantly since day 7000 (mid-2006): the emission latitude has gradually decreased, such that the overall geometry has become more similar to a ring structure. Around the same time, we find a decreasing trend in the east-west asymmetry of the surface emissivity. These results could reflect the increasing interaction of the forward shock with material around the circumstellar ring, and the relative weakening of the interaction with the lower-density material at higher latitudes. The morphological evolution caused an apparent break in the remnant expansion measured with a torus model, from a velocity of 4600+150-200 km/s between day 4000 and 7000 to 2400+100-200 km/s after day 7000. However, we emphasize that there is no conclusive evidence for a physical slowing of the shock at any given latitude in the expanding remnant, and that a change of radio morphology alone appears to dominate the evolution. This is supported by our ring-only fits which show a constant expansion of 3890+/-50 km/s without deceleration between days 4000 and 9000. We suggest that once the emission latitude no longer decreases, the expansion velocity obtained from the torus model should return to the same value as that measured with the ring model.Comment: 11 pages, 5 figures, accepted for publication in ApJ, Figure 1 has been scaled dow

High-resolution radio observations of SNR 1987A at high frequencies

We present new imaging observations of the remnant of Supernova (SN) 1987A at 44 GHz, performed in 2011 with the Australia Telescope Compact Array (ATCA). The 0\farcs35\times0\farcs23 resolution of the diffraction-limited image is the highest achieved to date in high-dynamic range. We also present a new ATCA image at 18 GHz derived from 2011 observations, which is super-resolved to 0\farcs25. The flux density is 40$\pm$2 mJy at 44 GHz and 81$\pm$6 mJy at 18 GHz. At both frequencies, the remnant exhibits a ring-like emission with two prominent lobes, and an east-west brightness asymmetry that peaks on the eastern lobe. A central feature of fainter emission appears at 44 GHz. A comparison with previous ATCA observations at 18 and 36 GHz highlights higher expansion velocities of the remnant eastern side. The 18-44 GHz spectral index is $\alpha=-0.80$ ($S_{\nu}\propto\nu^{\alpha}$). The spectral index map suggests slightly steeper values at the brightest sites on the eastern lobe, whereas flatter values are associated with the inner regions. The remnant morphology at 44 GHz generally matches the structure seen with contemporaneous X-ray and H$\alpha$ observations. Unlike the H$\alpha$ emission, both the radio and X-ray emission peaks on the eastern lobe. The regions of flatter spectral index align and partially overlap with the optically-visible ejecta. Simple free-free absorption models suggest that emission from a pulsar wind nebula or a compact source inside the remnant may now be detectable at high frequencies, or at low frequencies if there are holes in the ionised component of the ejecta.Comment: References updated. High resolution version may be found at http://ict.icrar.org/store/staff/gio/Papers/Zanardo_2013.pd

Low Radio Frequency Observations and Spectral Modelling of the Remnant of Supernova 1987A

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. ©: 2016 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.We present Murchison Widefield Array observations of the supernova remnant (SNR) 1987A between 72 and 230 MHz, representing the lowest frequency observations of the source to date. This large lever arm in frequency space constrains the properties of the circumstellar medium created by the progenitor of SNR 1987A when it was in its red supergiant phase. As of late-2013, the radio spectrum of SNR 1987A between 72 MHz and 8.64 GHz does not show any deviation from a non-thermal power-law with a spectral index of $-0.74 \pm 0.02$. This spectral index is consistent with that derived at higher frequencies, beneath 100 GHz, and with a shock in its adiabatic phase. A spectral turnover due to free-free absorption by the circumstellar medium has to occur below 72 MHz, which places upper limits on the optical depth of $\leq$ 0.1 at a reference frequency of 72 MHz, emission measure of $\lesssim$ 13,000 cm$^{-6}$ pc, and an electron density of $\lesssim$ 110 cm$^{-3}$. This upper limit on the electron density is consistent with the detection of prompt radio emission and models of the X-ray emission from the supernova. The electron density upper limit implies that some hydrodynamic simulations derived a red supergiant mass loss rate that is too high, or a wind velocity that is too low. The mass loss rate of $\sim 5 \times 10^{-6}$ $M_{\odot}$ yr$^{-1}$ and wind velocity of 10 km s$^{-1}$ obtained from optical observations are consistent with our upper limits, predicting a current turnover frequency due to free-free absorption between 5 and 60 MHz.Peer reviewedFinal Published versio

High resolution 36 GHz imaging of the Supernova Remnant of SN1987A

The aftermath of supernova (SN) 1987A continues to provide spectacular insights into the interaction between a SN blastwave and its circumstellar en- vironment. We here present 36 GHz observations from the Australia Telescope Compact Array of the radio remnant of SN 1987A. These new images, taken in 2008 Apr and 2008 Oct, substantially extend the frequency range of an ongo- ing monitoring and imaging program conducted between 1.4 and 20 GHz. Our 36.2 GHz images have a diffraction-limited angular resolution of 0.3-0.4 arcseconds, which covers the gap between high resolution, low dynamic range VLBI images of the remnant and low resolution, high dynamic range images at frequencies between 1 and 20 GHz. The radio morphology of the remnant at 36 GHz is an elliptical ring with enhanced emission on the eastern and western sides, similar to that seen previously at lower frequencies. Model fits to the data in the Fourier domain show that the emitting region is consistent with a thick inclined torus of mean radius 0.85 arcsec, and a 2008 Oct flux density of 27 +/- 6 mJy at 36.2 GHz. The spectral index for the remnant at this epoch, determined between 1.4 GHz and 36.2 GHz, is -0.83. There is tentative evidence for an unresolved central source with flatter spectral index.Comment: 34 pages, 9 figures in single column manuscript for

Multi-frequency Radio Measurements of SN 1987A over 22 Years

We present extensive observations of the radio emission from the remnant of SN 1987A made with the Australia Telescope Compact Array (ATCA), since the first detection of the remnant in 1990. The radio emission has evolved in time providing unique information on the interaction of the supernova shock with the circumstellar medium. We particularly focus on the monitoring observations at 1.4, 2.4, 4.8 and 8.6 GHz, which have been made at intervals of 4-6 weeks. The flux density data show that the remnant brightness is now increasing exponentially, while the radio spectrum is flattening. The current spectral index value of -0.68 represents an 18+/-3% increase over the last 8 years. The exponential trend in the flux is also found in the ATCA imaging observations at 9 GHz, which have been made since 1992, approximately twice a year, as well as in the 843 MHz data set from the Molonglo Observatory Synthesis Telescope from 1987 to March 2007. Comparisons with data at different wavelengths (X-ray, H\alpha) are made. The rich data set that has been assembled in the last 22 years forms a basis for a better understanding of the evolution of the supernova remnant.Comment: 37 pages, 11 figures, accepted by Ap

A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study

<p>Abstract</p> <p>Background</p> <p>An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (<it>IGF-1R</it>).</p> <p>Methods</p> <p>In an elderly population from North-eastern Italy (<it>n </it>= 668 subjects, age range 70–106 years) we investigated the <it>IGF-1R </it>polymorphism G3174A (<it>rs2229765</it>) and the plasma concentration of free IGF-1. Frequency distributions were compared using χ²-test "Goodness of Fit" test, and means were compared by one-way analysis of variance (ANOVA); multiple regression analysis was performed using JMP7 for SAS software (SAS Institute, USA). The limit of significance for genetic and biochemical comparison was set at α = 0.05.</p> <p>Results</p> <p>Males showed an age-related increase in the A-allele of <it>rs2229765 </it>and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age (85+ group). In the male 85+ group, A/A homozygous subjects had the lowest plasma IGF-1 level. We found no clear correlation between <it>rs2229765 </it>genotype and IGF-1 in the females.</p> <p>Conclusion</p> <p>These findings confirm the importance of the <it>rs2229765 </it>minor allele as a genetic predisposing factor for longevity in Italy where a sex-specific pattern for IGF-1 attenuation with ageing was found.</p

Increased Renal Methylglyoxal Formation with Down-Regulation of PGC-1α-FBPase Pathway in Cystathionine γ-Lyase Knockout Mice

We have previously reported that hydrogen sulfide (H2S), a gasotransmitter and vasodilator has cytoprotective properties against methylglyoxal (MG), a reactive glucose metabolite associated with diabetes and hypertension. Recently, H2S was shown to up-regulate peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α, a key gluconeogenic regulator that enhances the gene expression of the rate-limiting gluconeogenic enzyme, fructose-1,6-bisphosphatase (FBPase). Thus, we sought to determine whether MG levels and gluconeogenic enzymes are altered in kidneys of 6–22 week-old cystathionine γ-lyase knockout (CSE-/-; H2S-producing enzyme) male mice. MG levels were determined by HPLC. Plasma glucose levels were measured by an assay kit. Q-PCR was used to measure mRNA levels of PGC-1α and FBPase-1 and -2. Coupled-enzymatic assays were used to determine FBPase activity, or triosephosphate levels. Experimental controls were either age-matched wild type mice or untreated rat A-10 cells. Interestingly, we observed a significant decrease in plasma glucose levels along with a significant increase in plasma MG levels in all three age groups (6–8, 14–16, and 20–22 week-old) of the CSE-/- mice. Indeed, renal MG and triosephosphates were increased, whereas renal FBPase activity, along with its mRNA levels, were decreased in the CSE-/- mice. The decreased FBPase activity was accompanied by lower levels of its product, fructose-6-phosphate, and higher levels of its substrate, fructose-1,6-bisphosphate in renal extracts from the CSE-/- mice. In agreement, PGC-1α mRNA levels were also significantly down-regulated in 6-22 week-old CSE-/- mice. Furthermore, FBPase-1 and -2 mRNA levels were reduced in aorta tissues from CSE-/- mice. Administration of NaHS, a H2S donor, increased the gene expression of PGC-1α and FBPase-1 and -2 in cultured rat A-10 cells. In conclusion, overproduction of MG in CSE-/- mice is due to a H2S-mediated down-regulation of the PGC-1α-FBPase pathway, further suggesting the important role of H2S in the regulation of glucose metabolism and MG generation

Human eosinophil adhesion and degranulation stimulated with eotaxin and RANTES in vitro: Lack of interaction with nitric oxide

<p>Abstract</p> <p>Background</p> <p>Airway eosinophilia is considered a central event in the pathogenesis of asthma. The toxic components of eosinophils are thought to be important in inducing bronchial mucosal injury and dysfunction. Previous studies have suggested an interaction between nitric oxide (NO) and chemokines in modulating eosinophil functions, but this is still conflicting. In the present study, we have carried out functional assays (adhesion and degranulation) and flow cytometry analysis of adhesion molecules (VLA-4 and Mac-1 expression) to evaluate the interactions between NO and CC-chemokines (eotaxin and RANTES) in human eosinophils.</p> <p>Methods</p> <p>Eosinophils were purified using a percoll gradient followed by immunomagnetic cell separator. Cell adhesion and degranulation were evaluated by measuring eosinophil peroxidase (EPO) activity, whereas expression of Mac-1 and VLA-4 was detected using flow cytometry.</p> <p>Results</p> <p>At 4 h incubation, both eotaxin (100 ng/ml) and RANTES (1000 ng/ml) increased by 133% and 131% eosinophil adhesion, respectively. L-NAME alone (but not D-NAME) also increased the eosinophil adhesion, but the co-incubation of L-NAME with eotaxin or RANTES did not further affect the increased adhesion seen with chemokines alone. In addition, L-NAME alone (but not D-NAME) caused a significant cell degranulation, but it did not affect the CC-chemokine-induced cell degranulation. Incubation of eosinophils with eotaxin or RANTES, in absence or presence of L-NAME, did not affect the expression of VLA-4 and Mac-1 on eosinophil surface. Eotaxin and RANTES (100 ng/ml each) also failed to elevate the cyclic GMP levels above baseline in human eosinophils.</p> <p>Conclusion</p> <p>Eotaxin and RANTES increase the eosinophil adhesion to fibronectin-coated plates and promote cell degranulation by NO-independent mechanisms. The failure of CC-chemokines to affect VLA-4 and Mac-1 expression suggests that changes in integrin function (avidity or affinity) are rather involved in the enhanced adhesion.</p