Method for preparing ultra-high drug-loaded nanoparticles by means of sequence precipitation-complex coacervation

The invention discloses a kind of methods that sequence precipitation and complexation coacervation prepares superelevation medicine-carried nano particles, after first the first reactant and the second reactant are mixed in first reactor so that active pharmaceutical ingredient precipitates form medicament nano granule kernel in the first reactor;The reaction product of first reactor flows in second reactor rapidly, is mixed with third reactant, and enclosure material occurs to deposit to the surface of medicament nano granule kernel after complex coacervation reacts, and forms the superelevation medicine-carried nano particles with nucleocapsid

Nanoparticle with super high-drug loading capacity and manufacturing method thereof

A nanoparticle, a manufacturing method, and an apparatus for the manufacturing method. The nanoparticle comprises a nano-nucleus containing an active pharmaceutical ingredient, and an outer shell controlling the release of a pharmaceutical product. The mass of the active pharmaceutical ingredient comprises 30-85% of the mass of the entire nanoparticle. The nanoparticle has a diameter of 50-2,000 nm