A Novel Split-Course High-Dose Palliative Radiotherapy Regimen for Locally Advanced Sinonasal Cancer: A Case Report

Sinonasal malignancies (SNMs) are rare heterogeneous malignancies that frequently present with locally advanced disease. The prognosis is poor when the disease is considered extensive and unresectable. In such cases, a high-dose palliative radiotherapy regimen is often required, but the ideal dose and fractionation have not been established. We detail a 33-year-old male who initially presented with a progressively growing mass over the right cheek. A biopsy of the lesion revealed squamous cell carcinoma (SCC). Imaging revealed a very advanced and unresectable disease with the involvement of several head and neck subsites. He progressed further after receiving induction chemotherapy from an outside institution. The patient requested prompt tumor and symptom control to travel back to his home country. We offered him high-dose split-course palliative radiotherapy in the form of a quad Shot of 14.80 Gy in four fractions twice daily, followed by 30 Gy in five fractions every other day with a 2-week interval. Treatment resulted in excellent clinical response with symptomatic relief in a short time, and the patient could travel back home safely

Association between Social Jetlag and glycemic control in diabetic patients at King Saud University Medical City

Introduction: Social Jetlag has been linked to many cardiovascular and metabolic diseases, as it disturbs the circadian rhythm. Methodology: case-control matched by age and gender conducted among 511 subjects. Control group: Diabetic with HbA1c <7.5%, while cases: Diabetic with HbA1c 7.5% or more. We used Munich Chronotype Questionnaire to assess the Social Jetlag. Results: Social Jetlag status was similar among both cases and control participants which indicate that there was no significant association between Social Jetlag and HbA1c (P-value = 0.394). The prevalence of Social Jetlag in the studied population is 58.4%. Conclusion: We suggest future studies to have a more precise estimation of sleep duration and Social Jetlag and focusing on Social Jetlag and its related problems

Arabic patient-reported outcome measures for xerostomia and oral mucositis: Translation and cross-cultural adaptation

Introduction: Xerostomia and oral mucositis (OM) are common oral complications of head-and-neck cancer (HNC) radiotherapy. Aims: This study aimed to translate and assess the key validity and reliability properties of the Summated Xerostomia Inventory (SXI) and the patient-reported OM symptom (PROMS) in the Arabic patient cohort. Materials and Methods: This observational study was conducted at King Saud University Medical City, Riyadh, Saudi Arabia. Six expert clinicians translated both instruments and assessed them for content validity. They then evaluated validity (face and construct validity) and reliability (internal consistency and test–retest reliability) with adult participants who received radiotherapy for HNC. Results and Discussion: Thirty-eight patients (males = 19, females = 19) were recruited with a mean age of 50 years (±16). The Arabic SXI (SXI-Ar) and Arabic PROMS (PROMS-Ar) were considered relevant, sufficient, and understandable. Furthermore, high internal consistency was demonstrated by SXI-Ar (α = 0.851) and PROMS-Ar (α = 0.957). However, there were moderate to poor agreements between both instruments’ 1st and 2nd-week completions, as shown by the average correlation coefficients of 0.407 and −0.364, respectively. It was also evident that both xerostomia and OM scores were significantly correlated (r = 0.372, P = 0.043). Conclusions: SXI-Ar and PROMS-Ar showed preliminary satisfactory measurement properties. Both instruments could be used in daily clinical consultations and clinician-reported assessments in oncology, nutritional, and maxillofacial care settings. However, further assessments of hypotheses testing, criterion validity, and responsiveness with a large patient cohort are needed