Monte-Carlo Simulation of Domain-Wall Network in Two-dimensional Extended Supersymmetric Theory

We will show that 2-dimensional N=2-extended supersymmetric theory can have solitonic solution using the Hamilton-Jacobi method of classical mechanics. Then it is shown that the Bogomol'nyi mass bound is saturated by these solutions and triangular mass inequality is satisfied. At the end, we will mention domain-wall structure in 3-dimensional spacetime.Comment: Talk given at International Symposium on Non-Equilibrium and Nonlinear Dynamics in Nuclear and Other Finite Systems held at May 21-25, 2001 in Beijing. 7 pages, 4 figure

Operator ordering and Classical soliton path in Two-dimensional N=2 supersymmetry with Kahler potential

We investigate a 2-dimensional N=2 supersymmetric model which consists of n chiral superfields with Kahler potential. When we define quantum observables, we are always plagued by operator ordering problem. Among various ways to fix the operator order, we rely upon the supersymmetry. We demonstrate that the correct operator order is given by requiring the super Poincare algebra by carrying out the canonical Dirac bracket quantization. This is shown to be also true when the supersymmetry algebra has a central extension by the presence of topological soliton. It is also shown that the path of soliton is a straight line in the complex plane of superpotential W and triangular mass inequality holds. And a half of supersymmetry is broken by the presence of soliton.Comment: 13 pages, typos correcte

Physiological pathway of differentiation of hematopoietic stem cell population into mural cells

Endothelial cells (ECs), which are a major component of blood vessels, have been reported to develop in adulthood from hematopoietic cell populations, especially those of the monocyte lineage. Here we show that mural cells (MCs), another component of blood vessels, develop physiologically during embryogenesis from a hematopoietic stem cell (HSC) population, based on the in vitro culture of HSCs and histological examination of acute myeloid leukemia 1 mutant embryos, which lack HSCs. As in the embryo, HSCs in adult bone marrow differentiate into CD45+CD11b+ cells before differentiating into MCs. Moreover, CD45+CD11b+ cells are composed of two populations, CD11bhigh and CD11blow cells, both of which can differentiate into MCs as well as ECs. Interestingly, in a murine ischemia model, MCs and ECs derived from the CD11blow population had a long-term potential to contribute to the formation of newly developed blood vessels in vivo compared with the CD11high population, which could not. Moreover, injection of the CD11bhigh population induced leaky blood vessels, but the CD11blow population did not. With respect to the permeability of vessels, we found that angiopoietin 1, which is a ligand for Tie2 receptor tyrosine kinase expressed on ECs and is suggested to induce cell adhesion between ECs and MCs, is produced by the CD11blow population and plays a critical role in the formation of nonleaky vessels. These observations suggested that the CD11low cell population serves as a good source of cells for in vivo blood vessel regeneration

The association between adiponectin, HDL-cholesterol and α1-antitrypsin-LDL in female subjects without metabolic syndrome

<p>Abstract</p> <p>Background</p> <p>Oxidized low-density lipoprotein (LDL) may act as an atheroprotective (anti-atherosclerotic) agent under some conditions. While the α1-antitrypsin (AT)-LDL complex is considered a type of oxidized LDL, its clinical relevance remains unknown. The aim of the present study was to investigate the association between AT-LDL and anti-atherosclerotic variables such as HDL-cholesterol and adiponectin in subjects with and without metabolic syndrome (MetS).</p> <p>Methods</p> <p>In asymptomatic females (n = 194; mean age, 54 years) who were divided into non-MetS (n = 108) and MetS groups (n = 86), the fasting levels of serum AT-LDL, adiponectin and glucose/lipid panels were measured, in addition to body mass index (BMI) and blood pressure.</p> <p>Results</p> <p>The MetS group showed significantly higher BMI, blood pressure, glucose and triglyceride levels as well as significantly lower levels of HDL-cholesterol and adiponectin than the non-MetS group. A multivariate-adjusted analysis revealed that in the non-MetS group, AT-LDL was significantly, independently and positively correlated with adiponectin (β = 0.297, P < 0.05), along with HDL-cholesterol (β = 0.217, P < 0.05). In the MetS group, AT-LDL was significantly, independently and positively correlated with LDL-cholesterol only (β = 0.342, P < 0.05).</p> <p>Conclusions</p> <p>These data suggest that AT-LDL may exert anti-atherosclerotic effects in female subjects without MetS. More studies are required to clarify the clinical roles of AT-LDL in relation to the pathophysiology of MetS.</p

Effects of respiration on the vectorcardiogram obtained with the Frank lead system

Vectorcardiograms were recorded with the Frank lead system using electrodes positioned at the level of the 5 th intercostal space with the subject in the supine position. Deep inspiration produced the following significant changes compared with deep expiration: (1) the maximum leftward forces of the P, QRS, and T vectors decreased, whereas the maximum anterior and posterior forces of the QRS and T vectors increased; (2) the maximum spatial QRS vector decreased in magnitude; (3) the maximum spatial P, QRS, and T vectors shifted vertically, posteriorly and vertically, and anteriorly, respectively; and (4) the spatial QRS-T angle increased remarkably. The spatial instantaneous QRS vectors were analyzed at 5 msec intervals in 35 of the 61 subjects. With inspiration, the 35- through 50-msec vectors shifted posteriorly with markedly reduced leftward forces and increased posterior forces. It was suggested that the respiration-related vectorcardiographic changes reflected cardiac anatomic positional change, distortion of lead-field potential by lung gases, and other mechanisms. Since the respiratory effect is potentially important for vectorcardiographic interpretation, vectorcardiograms should be recorded under identical respiratory status.</p