Intra-Atrial Tumor Embolus in Hepatocellular Carcinoma

A case of hepatocellular carcinoma with a massive tumor embolus in the right atrium is reported. Although hepatocellular carcinoma often invades into portal and hepatic vein and may extend into the inferior vena cava, it is rare that the tumor grows out to fill the right atrium. The literature on the intracardiac metastasis of hepatocellular carcinoma as well as other carcinomas is reviewed

Multiorgan Involvement of Light Chain Deposition Disease : Report of an Autopsy Case

An autopsy case of light chain deposition disease is reported here. A 60-year-old female with plasmacytosis of the bone marrow was disclosed to have amorphous eosinophilic deposits in the kidneys and lungs. Glomerular deposits in kidneys were reminiscent of diabetic nodular glomerulosclerosis. Immunohistochemistry disclosed that they were composed of κ-light chain. Systemic deposition of κ-light chain may occur and should be kept in mind whenever eosinophilic amorphous substance is found in the background of plasma cell dyscrasias

PROSTATE-SPECIFIC ANTIGEN A Clue for the Prostatic Origin of Metastasis

The prostate-specific antigen is a recently purified glycoprotein which is present only in the prostatic gland. In order to confirm the usefulness of this protein in isolating prostatic carcinomas from socalled metastatic carcinomas of unknown primary site, we immunohistochemically studied 19 non-neoplastic prostatic tissue, 18 primary carcinomas of the prostate, and 32 non-prostatic adenocarcinomas. From our study, we concluded that PSA is highly specific for the prostatic carcinomas. The absence of PSA, however, does not necessarily rule out its prostatic origin when the tumor is poorly differentiated. In our laboratory, from now on, PSA will be applied routinely in cases of metastatic carcinomas of unknown origin

Bile Duct Carcinoma in Association with a Choledochal Cyst : Report of a Case

A case of bile duct carcinoma associated with a pre-existing type I-A choledochal cyst is reported here. A 38-year-old man who had received a Roux-en-Y hepaticojejunostomy for a cyst of the common bile duct 11 years earlier was revealed to have metastatic carcinoma in the lungs. The primary site of the carcinoma was clinically undetermined, but was found by autopsy to be in the bile duct. Although the relation between these two lesions was unclear, circumstantial evidence suggested that they were related to each other. A persistent chronic inflammatory irritation in this area was considered to be responsible for development of the tumor

Immunohistologic Analysis of Malignant Lymphoma 1. Accuracy of Histological Diagnosis and Usefulness of Monoclonal Antibodies

In order to test whether B cell or T cell origin of malignant lymphomas can be reliably suspected on histological basis alone, and to know the usefulness of some antibodies to lymphocytic cells which are currently available commercially, we reviewed 30 cases of malignant lymphomas both histologically and immunohistochemically. Hematoxylin- eosin stained sections from those cases were reclassified using Lukes and Collins\u27 classification with minor modification. Then, monoclonal antibodies; LCA, MT-1, and MB-1 have been applied to paraffin sections from same cases. In addition, four cases of plasmacytoma and a case of metastatic carcinoma which resembled malignant lymphoma were studied immunohistochemically. Our results indicate that (1) in most cases, T and B cell origin of lymphoma may be accurately classified by H-E stainecd section although further study with more cases is definitely necessary to reach this conclusion. (2) LCA immunoreactivity seemed to be stronger in lymphomas of T cell system. (3) MT-1 and MB-1 immunoreactivity did not correlate perfectly with LCA positivity. And (4) MT-1 ant MB-1 provide useful tools to dictate markers for T and B cell lymphomas in routinely fixed and paraffin-embedded tissue