HIV-1 did not contribute to the 2019-nCoV genome

When a new pathogen that causes a global epidemic in humans, one key question is where it comes from. This is especially important for a zoonotic infectious disease that jumps from animals to humans. Knowing the origin of such a pathogen is critical to develop means to block further transmission and to develop vaccines. Discovery of the origin of a newly human pathogen is a sophisticated process that requires extensive and vigorous scientific validations and generally takes many years, such as the cases for HIV-1, SARS and MERS. Unfortunately, before the natural sources of new pathogens are clearly defined, conspiracy theories that the new pathogens are man-made often surface as the source. However, in all cases, such theories have been debunked in history

Transforming Multidisciplinary Customer Requirements to Product Design Specifications

With the increasing of complexity of complex mechatronic products, it is necessary to involve multidisciplinary design teams, thus, the traditional customer requirements modeling for a single discipline team becomes difficult to be applied in a multidisciplinary team and project since team members with various disciplinary backgrounds may have different interpretations of the customers’ requirements. A new synthesized multidisciplinary customer requirements modeling method is provided for obtaining and describing the common understanding of customer requirements (CRs) and more importantly transferring them into a detailed and accurate product design specifications (PDS) to interact with different team members effectively. A case study of designing a high speed train verifies the rationality and feasibility of the proposed multidisciplinary requirement modeling method for complex mechatronic product development. This proposed research offersthe instruction to realize the customer-driven personalized customization of complex mechatronic product

Integrating View Conditions for Image Synthesis

In the field of image processing, applying intricate semantic modifications within existing images remains an enduring challenge. This paper introduces a pioneering framework that integrates viewpoint information to enhance the control of image editing tasks. By surveying existing object editing methodologies, we distill three essential criteria, consistency, controllability, and harmony, that should be met for an image editing method. In contrast to previous approaches, our method takes the lead in satisfying all three requirements for addressing the challenge of image synthesis. Through comprehensive experiments, encompassing both quantitative assessments and qualitative comparisons with contemporary state-of-the-art methods, we present compelling evidence of our framework's superior performance across multiple dimensions. This work establishes a promising avenue for advancing image synthesis techniques and empowering precise object modifications while preserving the visual coherence of the entire composition

Dimethyl 2-(2-quinolylmeth­yl)malonate

In the title compound, C15H15NO4, the quinoline ring system and one of the malonate side chains are essentially coplanar (r.m.s. deviation = 0.0297 Å). The two malonate C—C(=O)—O—CH3 side chains are oriented at right angles [89.68 (8)°] with respect to each other. The crystal packing is stabilized by weak non-classical inter­molecular C—H⋯O hydrogen bonds, which link the mol­ecules into dimers about inversion centers