The gender impact of pension reform : a cross-country analysis

Pension systems may have a different impact on gender because women are less likely than men to work in formal labor markets and earn lower wages when they do. Recent multipillar pension reforms tighten the link between payroll contributions and benefits, leading critics to argue that they will hurt women. In contrast, supporters of these reforms argue that it will help women by the removal of distortions that favored men and the better targeted redistributions in the new systems. To test these conflicting claims and to analyze more generally the gender effect of alternative pension systems, the authors examine the differential impact of the new and old systems in three Latin American countries-Argentina, Chile, and Mexico. Based on household survey data, they simulate the wage and employment histories of representative men and women, the pensions they are likely to generate under the new and old rules, and the relative gains or losses of men and women because of the reform. The authors find that women do accumulate private annuities that are only 30-40 percent those of men in the new systems. But this effect is mitigated by sharp targeting of the new public pillars toward low earners, many of whom are women, and by restrictions on payouts from the private pillars, particularly joint annuity requirements. As a result of these transfers, total lifetime retirement benefits for women reach 60-80 percent those of men, and for"full career"women they equal or exceed benefits of men. Also as a result, women are the biggest gainers from the pension reform. For women who receive these transfers, female/male ratios of lifetime benefits in the new systems exceed those in the old systems in all three countries. Private intra-household transfers from husband to wife in the form of joint annuities play the largest role.Pensions&Retirement Systems,Public Health Promotion,Health Monitoring&Evaluation,Population&Development,Gender and Development,Health Monitoring&Evaluation,Pensions&Retirement Systems,Population&Development,Agricultural Knowledge&Information Systems,Anthropology

The Role Of Folate In The Association Between Perinatal Air Pollution Exposure And Birth Outcomes In Lanzhou, China

Background: China’s rapid economic and industrial development over the past few decades has been accompanied by tremendous increases in air pollutant emissions and come at a serious cost to the environment and public health. Recent research has revealed an increased risk of adverse birth outcomes associated with perinatal air pollution exposure. Although the mechanisms by which air pollutants contribute to adverse birth outcomes have not yet been established, folate intake has been shown to counteract several of the hypothesized biological pathways. Hypothesis: Dietary folate intake and folic acid supplementation modify the association between perinatal air pollution exposure (PM10, NO2, SO2) and risk of preterm birth and low birth weight. Methods: A hospital-based cohort study in Lanzhou, China was conducted between 2010-2012. Demographic information and dietary intake during pregnancy were collected during an in-person interview near the time of delivery, and pregnancy outcomes and complications were abstracted from medical records. All 8,969 participants’ air pollutant exposures throughout pregnancy were calculated utilizing daily PM10, NO2, and SO2 levels from local air monitoring stations and inverse-distance weighting based on both residential and work addresses. Unconditional logistic regression modeling was used to examine the association between perinatal air pollution exposure and adverse birth outcomes and the role of folate as a potential effect modifier. Results: Mothers exposed to PM10 and SO2 levels above the Chinese NAAQS were at a higher unadjusted risk of adverse birth outcomes than mothers with exposure levels under the standards. Both folate supplementation and high dietary folate intake during pregnancy were significantly protective against both preterm birth and low birth weight without adjustment. Compared to women with air pollutant exposures below the China NAAQS who took folic acid supplements, mothers who did not supplement and had average PM10 and SO2 exposures during pregnancy above the NAAQS were at the highest risk of preterm birth and low birth weight. Women who supplemented with folic acid and were exposed to pollution above the NAAQS had the next highest observed risk, followed by women whose exposures were below the NAAQS but did not supplement. Similar results were observed for dietary folate intake. Mothers with low dietary folate intake and average PM10 and SO2 exposures above the China NAAQS were at the highest risk of both preterm birth and low birth weight, followed by mothers over the NAAQS with high dietary folate intake, and mothers under the NAAQS with low dietary folate intake. These trends were not observed for NO2. There was no significant interaction between folic acid supplementation or dietary folate intake and any of the air pollutant exposure variables in any of the models. Conclusion: Our findings support the hypothesis that perinatal exposure to PM10 and SO2 increases the risk of low birth weight and preterm birth. The highest observed risks of adverse birth outcomes were among women highly exposed to PM10 and SO2 with low dietary folate intake and who did not take folic acid supplements. These findings have important public health implications, as birth outcomes like birth weight and gestational age may be indicative of health outcomes later in life, and are relevant for future air pollution policies and standards as well as maternal nutrition recommendations

Mesenchymal Stem Cells: Angels or Demons?

Mesenchymal stem cells (MSCs) have been used in cell-based therapy in various disease conditions such as graft-versus-host and heart diseases, osteogenesis imperfecta, and spinal cord injuries, and the results have been encouraging. However, as MSC therapy gains popularity among practitioners and researchers, there have been reports on the adverse effects of MSCs especially in the context of tumour modulation and malignant transformation. These cells have been found to enhance tumour growth and metastasis in some studies and have been related to anticancer-drug resistance in other instances. In addition, various studies have also reported spontaneous malignant transformation of MSCs. The mechanism of the modulatory behaviour and the tumorigenic potential of MSCs, warrant urgent exploration, and the use of MSCs in patients with cancer awaits further evaluation. However, if MSCs truly play a role in tumour modulation, they can also be potential targets of cancer treatment

Extrinsic Factors Involved in the Differentiation of Stem Cells into Insulin-Producing Cells: An Overview

Diabetes mellitus is a chronic disease with many debilitating complications. Treatment of diabetes mellitus mainly revolves around conventional oral hypoglycaemic agents and insulin replacement therapy. Recently, scientists have turned their attention to the generation of insulin-producing cells (IPCs) from stem cells of various sources. To date, many types of stem cells of human and animal origins have been successfully turned into IPCs in vitro and have been shown to exert glucose-lowering effect in vivo. However, scientists are still faced with the challenge of producing a sufficient number of IPCs that can in turn produce sufficient insulin for clinical use. A careful choice of stem cells, methods, and extrinsic factors for induction may all be contributing factors to successful production of functional beta-islet like IPCs. It is also important that the mechanism of differentiation and mechanism by which IPCs correct hyperglycaemia are carefully studied before they are used in human subjects

Does a Recession have an Impact on Alcohol Consumption?

The hypothesis of this paper is alcohol consumption will decrease when a country experiences a recession. We have used data covering the yearly consumption (in litres per capita) of alcohol from the World Health Organization (2015), combined with yearly & quarterly GDP data from the OECD website (2015) to firstly identify years where there have been more than 2 periods of negative growth (recession), and to compare these data sets to see if any relationship exists.We have used correlation analysis between the financial data and the consumption data, as well as scatter graphs to see if there is a high correlation (0.7) or a trend, for 3 countries that have experienced a recession over the last 15 years (US, Finland & Greece). What we found is that some types of alcohol did appear to show both positive and negative relationships to GDP or recession but this relationship differed between countries. There are other factors that must be considered including cultural relationship to alcohol in different locations, as well as any government or social programs

Assessing risk to fresh water resources from long term CO2 injection- laboratory and field studies

In developing a site for geologic sequestration, one must assess potential consequences of failure to adequately contain injected carbon dioxide (CO2). Upward migration of CO2 or displacement of saline water because of increased pressure might impact protected water resources 100s to 1000s of meters above a sequestration interval. Questions posed are: (1) Can changes in chemistry of fresh water aquifers provide evidence of CO2 leakage from deep injection/sequestration reservoirs containing brine and or hydrocarbons? (2) What parameters can we use to assess potential impacts to water quality? (3) If CO2 leakage to freshwater aquifers occurs, will groundwater quality be degraded and if so, over what time period? Modeling and reaction experiments plus known occurrences of naturally CO2-charged potable water show that the common chemical reaction products from dissolution of CO2 into freshwater include rapid buffering of acidity by dissolution of calcite and slower equilibrium by reaction with clays and feldspars. Results from a series of laboratory batch reactions of CO2 with diverse aquifer rocks show geochemical response within hours to days after introduction of CO2. Results included decreased pH and increased concentrations of cations in CO2 experimental runs relative to control runs using argon (Ar). Some cation (Ba, Ca, Fe, Mg, Mn, and Sr) concentrations increased over and an order of magnitude during CO2 runs. Results are aquifer dependant in that experimental vessels containing different aquifer rocks showed different magnitudes of increase in cation concentrations. Field studies designed to improve understanding of risk to fresh water are underway in the vicinity of (1) SACROC oilfield in Scurry County, Texas, USA where CO2 has been injected for enhanced oil recovery (EOR) since 1972 and (2) the Cranfield unit in Adams County, Mississippi, USA where CO2 EOR is currently underway. Both field studies are funded by the U.S. Department of Energy (DOE) regional carbon sequestration partnership programs and industrial sponsors. Preliminary results of groundwater monitoring are currently available for the SACROC field study where researchers investigated 68 water wells and one spring during five field excursions between June 2006 and July 2008. Results to date show no trend of preferential degradation below drinking water standards in areas of CO2 injection (inside SACROC) as compared to areas outside of the SACROC oil field.Bureau of Economic Geolog

Modifying monolayer behaviour by incorporating subphase additives and improving Langmuir–Blodgett thin film deposition on optical fibres

Experiments showing the possibility of modifying the behaviour of calix[4]resorcinarene monolayers at the air–water interface and optimising the deposition of multilayer coatings onto optical fibres are presented. The nature of the subphase is fundamental to the behaviour of monolayers and their utility in coating and sensing applications. Here we show initial studies exploring the modification of the calix[4]resorcinarene monolayer–water interaction through the introduction of dipole altering alcohol additives to the aqueous subphase. We explored the effect of this modification for three small alcohols. The resulting isotherms of the materials showed a reduction in the surface pressure and area per molecule required in order for the monolayer to reach its point of collapse. Incorporation of alcohols shifted the point of collapse, leading to the application of ethanol being successful in improving the transfer of material via Langmuir–Blodgett coating onto optical fibres at lower pressures. This method may prove useful in allowing greater control over future sensor surface coatings

The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes

© The Author(s) 2017. Methylated cytosines (5mCs) are frequently mutated in the genome. However, no studies have yet comprehensively analysed mutation-methylation associations across cancer types. Here we analyse 916 cancer genomes, together with tissue type-specific methylation and replication timing data. We describe a strong mutation-methylation association across colorectal cancer subtypes, most interestingly in samples with microsatellite instability (MSI) or Polymerase epsilon (POLE) exonuclease domain mutations. By analysing genomic regions with differential mismatch repair (MMR) efficiency, we suggest a possible role for MMR in the correction of 5mC deamination events, potentially accounting for the high rate of 5mC mutation accumulation in MSI tumours. Additionally, we propose that mutant POLE asserts a mutator phenotype specifically at 5mCs, and we find coding mutation hotspots in POLE-mutant cancers at highly-methylated CpGs in the tumour-suppressor genes APC and TP53. Finally, using multivariable regression models, we demonstrate that different cancers exhibit distinct mutation-methylation associations, with DNA repair influencing such associations in certain cancer genomes. Taken together, we find differential associations with methylation that are vital for accurately predicting expected mutation loads across cancer types. Our findings reveal links between methylation and common mutation and repair processes, with these mechanisms defining a key part of the mutational landscape of cancer genomes.Link_to_subscribed_fulltex