Performance of an induction motor

Thesis (B.S.)--University of Illinois, 1902.Typescript

"Wenn Ihnen der liebe Gott zwei Zehntelsekunden oder das 'Mhm' schenken würde, dann könnten Sie die Welt verändern." Stephan Wolff im Gespräch mit René Salomon

Stephan WOLFF zeichnet in diesem Interview die Entwicklung seines eigenen theoretischen und methodischen Vorgehens und akademischen Werdegangs nach. Dabei wird deutlich, dass es WOLFF gelungen ist, die Ethnomethodologie als eine äußerst gewinnbringende, aber eben auch flexible Haltung zu betrachten. Dies ermöglichte ihm, auf verschiedene sozial- und gesellschaftstheoretische Angebote zurückzugreifen und diese durch eine ethnomethodologische Grundhaltung so zu operationalisieren, dass sie ethnografische Studien in verschiedensten Feldern informieren konnten. Stephan WOLFF schaffte es dadurch wie kaum ein anderer deutscher Soziologe, den ethnomethodologischen Ansatz für andere Fachdisziplinen fruchtbar zu machen und in diese hineinzutragen. Das Interview bietet einen Einblick in die Situation der bundesrepublikanischen geisteswissenschaftlichen Theorie- und Forschungslandschaft seit den 1970er Jahren und zeichnet detailliert die Rezeptionsgeschichte der Ethnomethodologie nach. Dabei wird deutlich, wie schwerfällig die deutsche Soziologie auf die Ethnomethodologie reagierte und wie sehr eine Rezeptionsgeschichte von dem Engagement einzelner Personen abhängen kann

Information Behavior towards False Information and “Fake News” on Facebook: The Influence of Gender, User Type and Trust in Social Media

In this paper, we present a survey study with 119 participants conducted in German, which investigates respondents’ Facebook behavior. In particular, the survey provides insight into how the individual factors gender, user type and trust in social media influence information behavior with respect to false information on Facebook. Our participants’ Facebook use is predominantly passive, the trust in social media is mediocre and most users claim to encounter false information on a weekly basis. If the truthfulness of information is verified it is mostly done by checking alternative sources and for the most part, users do not react actively to false information on Facebook. Of the different categories of Facebook users studied, more active and intensive users of Facebook (posters and heavy users) encounter false information the most. These users are the only user group to report posts with false information to Facebook or interact with the post. Participants with higher trust in social media tend to check the comments of a post to verify information

Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients

Background: This study assessed the human epidermal growth factor receptor-2 (HER2) protein expression and its relationship with gene amplification in invasive bladder carcinoma, using the same criteria than for breast cancer

Exploring Snowfall Variability through the High-Latitude Measurement of Snowfall (HiLaMS) Field Campaign

The High-Latitude Measurement of Snowfall (HiLaMS) campaign explored variability in snowfall properties and processes at meteorologically distinct field sites located in Haukeliseter, Norway, and Kiruna, Sweden, during the winters of 2016/17 and 2017/18, respectively. Campaign activities were founded upon the sensitivities of a low-cost, core instrumentation suite consisting of Micro Rain Radar, Precipitation Imaging Package, and Multi-Angle Snow Camera. These instruments are highly portable to remote field sites and, considered together, provide a unique and complementary set of snowfall observations including snowflake habit, particle size distributions, fall speeds, surface snowfall accumulations, and vertical profiles of radar moments and snow water content. These snow-specific parameters, used in combination with existing observations from the field sites such as snow gauge accumulations and ambient weather conditions, allow for advanced studies of snowfall processes. HiLaMS observations were used to 1) successfully develop a combined radar and in situ microphysical property retrieval scheme to estimate both surface snowfall accumulation and the vertical profile of snow water content, 2) identify the predominant snowfall regimes at Haukeliseter and Kiruna and characterize associated macrophysical and microphysical properties, snowfall production, and meteorological conditions, and 3) identify biases in the HARMONIE-AROME numerical weather prediction model for forecasts of snowfall accumulations and vertical profiles of snow water content for the distinct snowfall regimes observed at the mountainous Haukeliseter site. HiLaMS activities and results suggest value in the deployment of this enhanced snow observing instrumentation suite to new and diverse high-latitude locations that may be underrepresented in climate and weather process studies.Exploring Snowfall Variability through the High-Latitude Measurement of Snowfall (HiLaMS) Field CampaignpublishedVersio

Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production

Large scale continuous cell‐line cultures promise greater reproducibility and efficacy for the production of influenza vaccines, and adenovirus for gene therapy. This paper seeks to use an existing validated ultra scale‐down tool, which is designed to mimic the commercial scale process environment using only milliliters of material, to provide some initial insight into the performance of the harvest step for these processes. The performance of industrial scale centrifugation and subsequent downstream process units is significantly affected by shear. The properties of these cells, in particular their shear sensitivity, may be changed considerably by production of a viral product, but literature on this is limited to date. In addition, the scale‐down tool used here has not previously been applied to the clarification of virus production processes. The results indicate that virus infected cells do not actually show any increase in sensitivity to shear, and may indeed become less shear sensitive, in a similar manner to that previously observed in old or dead cell cultures. Clarification may be most significantly dependent on the virus release mechanism, with the budding influenza virus producing a much greater decrease in clarification than the lytic, non‐enveloped adenovirus. A good match was also demonstrated to the industrial scale performance in terms of clarification, protein release, and impurity profile.UK Engineering and Physical Sciences Research Council, EPSRC. Grant Number: EP/G034656/1Published versio

What specific modes of internationalization influence SME innovation in Sub-Saharan least developed countries (LDCs)?

Small and medium sized enterprises (SMEs) located in the least developed countries (LDCs), operate in distinctively hostile institutional environments compared to those in developed economies. Better understanding of the determinants of SME innovation in such environments is important for the development of private sector in LDCs, because innovative SMEs are crucial for sustainable economic growth. Yet, determinants of SME innovation in LDCs have hardly been studied. Considering the potential relevance of internationalization for SME innovation in LDCs, as means of overcoming domestic environmental constraints, this paper investigates the influence of foreign technology licensing, exports and imports on SME innovation in LDCs. The study employs data from 1058 manufacturing SMEs from Sub-Saharan LDCs - Djibouti, Tanzania, Uganda, Zambia and the Democratic Republic of Congo. The findings suggest that foreign technology licensing is found to be positively and statistically associated with SME product and process innovations in Sub-Saharan LDCs. Findings are compared with those from developed economies in order to identify distinctive features. The implication is that SMEs in Sub-Saharan LDCs need to be supported by different policies compared to developed economies. The results also show that R&D, firm size, sectoral characteristics and access to finance are important determinants of SME innovation

8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis

BACKGROUND: Breast cancer is a heterogeneous disease that is not totally eradicated by current therapies. The classification of breast tumors into distinct molecular subtypes by gene profiling and immunodetection of surrogate markers has proven useful for tumor prognosis and prediction of effective targeted treatments. The challenge now is to identify molecular biomarkers that may be of functional relevance for personalized therapy of breast tumors with poor outcome that do not respond to available treatments. The Mitochondrial Tumor Suppressor (MTUS1) gene is an interesting candidate whose expression is reduced in colon, pancreas, ovary and oral cancers. The present study investigates the expression and functional effects of MTUS1 gene products in breast cancer. METHODS AND FINDINGS: By means of gene array analysis, real-time RT-PCR and immunohistochemistry, we show here that MTUS1/ATIP3 is significantly down-regulated in a series of 151 infiltrating breast cancer carcinomas as compared to normal breast tissue. Low levels of ATIP3 correlate with high grade of the tumor and the occurrence of distant metastasis. ATIP3 levels are also significantly reduced in triple negative (ER- PR- HER2-) breast carcinomas, a subgroup of highly proliferative tumors with poor outcome and no available targeted therapy. Functional studies indicate that silencing ATIP3 expression by siRNA increases breast cancer cell proliferation. Conversely, restoring endogenous levels of ATIP3 expression leads to reduced cancer cell proliferation, clonogenicity, anchorage-independent growth, and reduces the incidence and size of xenografts grown in vivo. We provide evidence that ATIP3 associates with the microtubule cytoskeleton and localizes at the centrosomes, mitotic spindle and intercellular bridge during cell division. Accordingly, live cell imaging indicates that ATIP3 expression alters the progression of cell division by promoting prolonged metaphase, thereby leading to a reduced number of cells ungergoing active mitosis. CONCLUSIONS: Our results identify for the first time ATIP3 as a novel microtubule-associated protein whose expression is significantly reduced in highly proliferative breast carcinomas of poor clinical outcome. ATIP3 re-expression limits tumor cell proliferation in vitro and in vivo, suggesting that this protein may represent a novel useful biomarker and an interesting candidate for future targeted therapies of aggressive breast cancer

HER2 Status in Ovarian Carcinomas: A Multicenter GINECO Study of 320 Patients

BACKGROUND: Despite a typically good response to first-line combination chemotherapy, the prognosis for patients with advanced ovarian cancer remains poor because of acquired chemoresistance. The use of targeted therapies such as trastuzumab may potentially improve outcomes for patients with ovarian cancer. HER2 overexpression/amplification has been reported in ovarian cancer, but the exact percentage of HER2-positive tumors varies widely in the literature. In this study, HER2 gene status was evaluated in a large, multicentric series of 320 patients with advanced ovarian cancer, including 243 patients enrolled in a multicenter prospective clinical trial of paclitaxel/carboplatin-based chemotherapy. METHODOLOGY/PRINCIPAL FINDINGS: The HER2 status of primary tumors and metastases was evaluated by both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) analysis of paraffin-embedded tissue on conventional slides. The prognostic impact of HER2 expression was analyzed. HER2 gene was overexpressed and amplified in 6.6% of analyzed tumors. Despite frequent intratumoral heterogeneity, no statistically significant difference was detected between primary tumors and corresponding metastases. CONCLUSIONS/SIGNIFICANCE: Our results show that the decision algorithm usually used in breast cancer (IHC as a screening test, with equivocal results confirmed by FISH) is appropriate in ovarian cancer. In contrast to previous series, HER2-positive status did not influence outcome in the present study, possibly due to the fact that patients in our study received paclitaxel/carboplatin-based chemotherapy. This raises the question of whether HER2 status and paclitaxel sensitively are linked