Diana Waltzes

https://digitalcommons.library.umaine.edu/mmb-ps/2060/thumbnail.jp

The First Violin : Waltzes

https://digitalcommons.library.umaine.edu/mmb-ps/2992/thumbnail.jp

The moth and the flame /

https://digitalcommons.library.umaine.edu/mmb-vp/4006/thumbnail.jp

My Heart\u27s To-Night In Texas : By The Silvery Rio Grande

https://digitalcommons.library.umaine.edu/mmb-vp/2184/thumbnail.jp

My Heart\u27s To-Night In Texas : By The Silvery Rio Grande

https://digitalcommons.library.umaine.edu/mmb-vp/2185/thumbnail.jp

I Like Your Way

https://digitalcommons.library.umaine.edu/mmb-vp/3571/thumbnail.jp

My Clinging Ivy : My Ivy Green

https://digitalcommons.library.umaine.edu/mmb-vp/2168/thumbnail.jp

My Heart\u27s To-Night In Texas

Red tinted photograph of Lottie Colson inset against an illustration of green vines.https://scholarsjunction.msstate.edu/cht-sheet-music/2579/thumbnail.jp

The First Violin

Photograph of Richard Mansfield and woman holding hands; Illustration of trees with mansion on top of mountain in backgroundhttps://scholarsjunction.msstate.edu/cht-sheet-music/11414/thumbnail.jp

A Common Variant of PNPLA3 (p.I148M) Is Not Associated with Alcoholic Chronic Pancreatitis

Contains fulltext : 110441.pdf (publisher's version ) (Open Access)BACKGROUND: Chronic pancreatitis (CP) is an inflammatory disease that in some patients leads to exocrine and endocrine dysfunction. In industrialized countries the most common aetiology is chronic alcohol abuse. Descriptions of associated genetic alterations in alcoholic CP are rare. However, a common PNPLA3 variant (p.I148M) is associated with the development of alcoholic liver cirrhosis (ALC). Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M) possibly influences the development of alcoholic CP. METHODS: Using melting curve analysis we genotyped the variant in 1510 patients with pancreatitis or liver disease (961 German and Dutch alcoholic CP patients, 414 German patients with idiopathic or hereditary CP, and 135 patients with ALC). In addition, we included in total 2781 healthy controls in the study. RESULTS: The previously published overrepresentation of GG-genotype was replicated in our cohort of ALC (p-value <0.0001, OR 2.3, 95% CI 1.6-3.3). Distributions of genotype and allele frequencies of the p.I148M variant were comparable in patients with alcoholic CP, idiopathic and hereditary CP and in healthy controls. CONCLUSIONS: The absence of an association of PNPLA3 p.I148M with alcoholic CP seems not to point to a common pathway in the development of alcoholic CP and alcoholic liver cirrhosis