171 research outputs found

    Host‐Response Therapeutics for Periodontal Diseases

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141161/1/jper1592.pd

    Getting to the Root of dental implant tissue engineering

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    Giannobile WV. Getting to the Root of dental implant tissue engineering. J Clin Peridontol 2010; 37: 747-749 doi: .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79316/1/j.1600-051X.2010.01589.x.pd

    Periodontal Surveillance – Prospects for the Future

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141014/1/jper1365.pd

    Periodontal Surveillance – Implications in the Promotion of Public Health

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142113/1/jper1177.pd

    Enhancing Periodontal Health Through Regenerative Approaches

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142301/1/jpers1.pd

    Epigenetics and Its Role in Periodontal Diseases: A State‐of‐the‐Art Review

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141896/1/jper0556.pd

    Gene therapy for periodontal bioengineering

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    Although significant advancements have been achieved in periodontal therapy over the last decade, predictable regeneration of the tooth-supporting tissues is a challenge in periodontology and oral implantology. Recently, gene therapy, a new therapeutic approach for genetic and acquired diseases, has been applied for tissue bioengineering in multiple clinical situations, including the craniofacial complex, among them defects resulting from periodontal disease. The use of gene therapy vectors has enhanced the bioavailability and targeting of multiple growth and host immune factors to repair alveolar bone defects. Early pre-clinical studies utilizing both ex vivo and in vivo gene transfer strategies demonstrate the feasibility of using gene therapy for periodontal tissue engineering. This review highlights the current progress made in the field of periodontal regenerative medicine via gene targeting approaches

    When epigenetics meets bioengineering—A material characteristics and surface topography perspective

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    The field of tissue engineering and regenerative medicine (TE/RM) involves regeneration of tissues and organs using implantable biomaterials. The term epigenetics refers to changes in gene expression that are not encoded in the DNA sequence, leading to remodeling of the chromatin and activation or inactivation of gene expression. Recently, studies have demonstrated that these modifications are influenced not only by biological cues but also by mechanical and topographical signals. This review highlights the current knowledge on emerging approaches in TE/RM with a focus on the effect of materials and topography on the epigenetic expression pattern in cells with potential impacts on modulating regenerative biology. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2065–2071, 2018.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144628/1/jbmb33953.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144628/2/jbmb33953_am.pd
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