Stapeloptimierung einer Haubengluehanlage mit Hilfe von Evolutionsstrategien Eine Machbarkeitsuntersuchung

SIGLEAvailable from TIB Hannover: RR 6055(95-03) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany)DEGerman

ANNIE, a Tool for Integrating Ergonomics in the Design of Car Interiors

An example of a result from a long-term cooperation with\ua0Lund University (together with professor Roland Akselsson at the Department\ua0for Work Environment) there some of the authors (Engstr\uf6m)\ua0gained extensive\ua0grants (Wallenberg Stifelsen regarding\ua0equipment as well as other founding from e.g. the Swedish Work Environment Found). In this case the just mentioned EU-financing

Annie, a Tool for Integrating Ergonomics in the Design of Car Interiors

An example of a result from a long-term cooperation with\ua0Lund University (together with professor Roland Axelsson at the Department\ua0for Work Environment) there some of the authors. (Engstr\uf6m)\ua0gained extensive\ua0grants (Wallenberg Stifelsen regarding\ua0equipment as well as other founding from e.g. the Swedish Work Environment Found)

Estimating Relevant Input Dimensions for Self-organizing Algorithms

this paper. Approaches like [11] clearly indicate that often a considerable reduction of the data dimension is possible without loss of informatio

Maternal autoimmunity and inflammation are associated with childhood tics and obsessive-compulsive disorder: Transcriptomic data show common enriched innate immune pathways.

Although genetic variation is a major risk factor of neurodevelopmental disorders, environmental factors during pregnancy and early life are also important in disease expression. Animal models demonstrate that maternal inflammation causes fetal neuroinflammation and neurodevelopmental deficits, and brain transcriptomics of neurodevelopmental disorders in humans show upregulated differentially expressed genes are enriched in immune pathways. We prospectively recruited 200 sequentially referred children with tic disorders/obsessive-compulsive disorder (OCD), 100 autoimmune neurological controls, and 100 age-matched healthy controls. A structured interview captured the maternal and family history of autoimmune disease and other pro-inflammatory states. Maternal blood and published Tourette brain transcriptomes were analysed for overlapping enriched pathways. Mothers of children with tics/OCD had a higher rate of autoimmune disease compared with mothers of children with autoimmune neurological conditions (p = 0.054), and mothers of healthy controls (p = 0.0004). Autoimmunity was similarly elevated in first- and second-degree maternal relatives of children with tics/OCD (p < 0.0001 and p = 0.014 respectively). Other pro-inflammatory states were also more common in mothers of children with tics/OCD than controls (p < 0.0001). Upregulated differentially expressed genes in maternal autoimmune disease and Tourette brain transcriptomes were commonly enriched in innate immune processes. Pro-inflammatory states, including autoimmune disease, are more common in the mothers and families of children with tics/OCD. Exploratory transcriptome analysis indicates innate immune signalling may link maternal inflammation and childhood tics/OCD. Targeting inflammation may represent preventative strategies in pregnancy and treatment opportunities for children with neurodevelopmental disorders