A North American dust emission climatology (2001–2020) calibrated to dust point sources from satellite observations

Measurements of atmospheric dust have long influenced our understanding of dust sources and dust model calibration. However, assessing dust emission magnitude and frequency may reveal different dust source dynamics and is critical for informing land management. Here we use MODIS (500 m) albedo-based daily wind friction estimates to produce a new dust emission climatology of North America (2001–2020), calibrated by the novel use of dust point sources from optical satellite observations (rather than being tuned to dust in the atmosphere). Calibrated dust emission occurred predominantly in the biomes of the Great Plains (GP) and North American Deserts (NAD), in broad agreement with maps of aerosol optical depth and dust deposition but with considerably smaller frequency and magnitude. Combined, these biomes produced 7.2 Tg y-1 with contributions split between biomes (59.8% NAD, 40.2% GP) due to the contrasting conditions. Dust emission is dependent on different wind friction conditions on either side of the Rocky Mountains. In general, across the deserts, aerodynamic roughness was persistently small and dust sources were activated in areas prone to large wind speeds; desert dust emissions were wind speed limited. Across the Great Plains, large winds persist, and dust emission occurred when vegetation cover was reduced; vegetated dust emissions were roughness limited. We found comparable aerodynamic roughness exists across biomes/vegetation classes demonstrating that dust emission areas are not restricted to a single biome, instead they are spread across an ‘envelope’ of conducive wind friction conditions. Wind friction dynamics, describing the interplay between changing vegetation roughness (e.g., due to climate and land management) and changing winds (stilling and its reversal), influence modelled dust emission magnitude and frequency and its current and future climatology. We confirm previous results that in the second half of the 21st century the southern Great Plains is the most vulnerable to increased dust emission and show for the first time that risk is due to increased wind friction (by decreased vegetation roughness and / or increased wind speed). Regardless of how well calibrated models are to atmospheric dust, assuming roughness is static in time and / or homogeneous over space, will not adequately represent current and future dust source dynamics

Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites

The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions. The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that the wood in the starch composites did not prevent water loss from the samples.Peer reviewe

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Pressure of perfection Mental Health on College Campuses

Personal stories of students with mental health issues and suggestions for how to reduce pressure when you recognize warning signs or risk factors

A North American dust emission climatology (2001–2020) calibrated to dust point sources from satellite observations

Measurements of atmospheric dust have long influenced our understanding of dust sources and dust model calibration. However, assessing dust emission magnitude and frequency may reveal different dust source dynamics and is critical for informing land management. Here we use MODIS (500 m) albedo-based daily wind friction estimates to produce a new dust emission climatology of North America (2001–2020), calibrated by the novel use of dust point sources from optical satellite observations (rather than being tuned to dust in the atmosphere). Calibrated dust emission occurred predominantly in the biomes of the Great Plains (GP) and North American Deserts (NAD), in broad agreement with maps of aerosol optical depth and dust deposition but with considerably smaller frequency and magnitude. Combined, these biomes produced 7.2 Tg y-1 with contributions split between biomes (59.8% NAD, 40.2% GP) due to the contrasting conditions. Dust emission is dependent on different wind friction conditions on either side of the Rocky Mountains. In general, across the deserts, aerodynamic roughness was persistently small and dust sources were activated in areas prone to large wind speeds; desert dust emissions were wind speed limited. Across the Great Plains, large winds persist, and dust emission occurred when vegetation cover was reduced; vegetated dust emissions were roughness limited. We found comparable aerodynamic roughness exists across biomes/vegetation classes demonstrating that dust emission areas are not restricted to a single biome, instead they are spread across an ‘envelope’ of conducive wind friction conditions. Wind friction dynamics, describing the interplay between changing vegetation roughness (e.g., due to climate and land management) and changing winds (stilling and its reversal), influence modelled dust emission magnitude and frequency and its current and future climatology. We confirm previous results that in the second half of the 21st century the southern Great Plains is the most vulnerable to increased dust emission and show for the first time that risk is due to increased wind friction (by decreased vegetation roughness and / or increased wind speed). Regardless of how well calibrated models are to atmospheric dust, assuming roughness is static in time and / or homogeneous over space, will not adequately represent current and future dust source dynamics

Evaluation of VEGF-mediated signaling in primary human cells reveals a paracrine action for VEGF in osteoblast-mediated crosstalk to endothelial cells

Communication between endothelial and bone cells is crucial for controlling vascular supply during bone growth, remodeling, and repair but the molecular mechanisms coordinating this intercellular crosstalk remain ill-defined. We have used primary human and rat long bone-derived osteoblast-like cells (HOB and LOB) and human umbilical vein endothelial cells (HUVEC) to interrogate the potential autocrine/paracrine role of vascular endothelial cell growth factor (VEGF) in osteoblast:endothelial cell (OB:EC) communication and examined whether prostaglandins (PG), known modulators of both OB and EC behavior, modify VEGF production. We found that the stable metabolite of PGI2, 6-keto-PGF(1alpha) and PGE2, induced a concentration-dependent increase in VEGF release by HOBs but not ECs. In ECs, VEGF promoted early ERK1/2 activation, late cyclooxygenase-2 (COX-2) protein induction, and release of 6-keto-PGF1alpha. In marked contrast, no significant modulation of these events was observed in HOBs exposed to VEGF, but LOBs clearly exhibited COX-dependent prostanoid release (10-fold less than EC) following VEGF treatment. A low level of osteoblast-like cell responsiveness to exogenous VEGF was supported by VEGFR2/Flk-1 immunolabelling and by blockade of VEGF-mediated prostanoid generation by a VEGFR tyrosine kinase inhibitor (TKI). HOB alkaline phosphatase (ALP) activity was increased following long-term non-contact co-culture with ECs and exposure of ECs to VEGF in this system further increased OB-like cell differentiation and markedly enhanced prostanoid release. Our studies confirm a paracrine EC-mediated effect of VEGF on OB-like cell behavior and are the first supporting a model in which prostanoids may facilitate this unidirectional VEGF-driven OB:EC communication. These findings may offer novel regimes for modulating pathological bone remodeling anomalies through the control of the closely coupled vascular supply