Approximate g-functions for selection of borehole field configurations used with ground-source heat pump systems

The arrangement of boreholes in ground heat exchangers used with ground-source heat pump systems is commonly based on pre-computed libraries of g-functions with standard configurations, e.g. placing the boreholes on a uniformly-spaced rectangular grid. Particularly for larger fields with many boreholes in situations with significant annual heat rejection/extraction imbalance, these configurations may be far from optimal. That is, depending on the space constraints, it may be possible to reduce the number of boreholes and amount of drilling required by shifting the positions of the boreholes to make better use of the available space. These configurations of boreholes are unlikely to be found in any library. Furthermore, manual arrangement of boreholes in complex-shaped fields is tedious and time-consuming for the engineer. Therefore, tools are needed that can automatically arrange boreholes in candidate configurations to fit the available land area, calculate the g-function for these configurations, select the best configuration, and determine the required depth for the best configuration. These tools need to be reasonably fast in order to be practical for the design engineer. This paper reports on a fast method for calculating approximate g-functions using non-uniform segments and pre-computed integral tables. Despite being “approximate” g-functions, the difference between a g-function calculated with a more detailed method and the approximate g-function is usually under 1% RMSE. The g-functions for borehole fields with 300, 500, and 1000 boreholes can be calculated in about 2, 6, and 30 seconds on a run-of-the-mill desktop PC. The paper presents the methodology, quantifies the computational time requirements and accuracy of both the g-function and the resulting designs.Mechanical and Aerospace Engineerin

A randomised controlled study of high intensity exercise as a dishabituating stimulus to improve hypoglycaemia awareness in people with type 1 diabetes:a proof of concept study

Aims/hypothesis Approximately 25% of people with type 1 diabetes have suppressed counterregulatory hormonal and symptomatic responses to insulin-induced hypoglycaemia, which renders them at increased risk of severe, disabling hypoglycaemia. This is called impaired awareness of hypoglycaemia (IAH), the cause of which is unknown. We recently proposed that IAH develops through habituation, a form of adaptive memory to preceding hypoglycaemia. Consistent with this hypothesis, we demonstrated restoration of defective counterregulatory hormonal responses to hypoglycaemia (referred to as dishabituation) in a rodent model of IAH following introduction of a novel stress stimulus (high intensity training [HIT]). In this proof-of-concept study we sought to further test this hypothesis by examining whether a single episode of HIT would amplify counterregulatory responses to subsequent hypoglycaemia in people with type 1 diabetes who had IAH (assessed by Gold score ≥4, modified Clarke score ≥4 or Dose Adjustment For Normal Eating (DAFNE) hypoglycaemia awareness rating 2 or 3). The primary outcome was the difference in adrenaline response to hypoglycaemia following both a single episode of HIT and rest. Methods In this randomised, crossover study 12 participants aged between 18 and 55 years with type 1 diabetes for ≥5 years and an HbA1c < 75 mmol/mol (9%) were recruited. Individuals were randomised using computer generated block randomisation to start with one episode of HIT (4 × 30 s cycle sprints [2 min recovery] at 150% of maximum wattage achieved during V˙O2peak assessment) or rest (control). The following day they underwent a 90 min hyperinsulinaemic–hypoglycaemic clamp study at 2.5 mmol/l with measurement of hormonal counterregulatory response, symptom scores and cognitive testing (four-choice reaction time and digit symbol substitution test). Each intervention and subsequent clamp study was separated by at least 2 weeks. The participants and investigators were not blinded to the intervention or measurements during the study. The investigators were blinded to the primary outcome and blood analysis results. Results All participants (six male and six female, age 19–54 years, median [IQR] duration of type 1 diabetes 24.5 [17.3–29.0] years, mean [SEM] HbA1c 56 [3.67] mmol/mol; 7.3% [0.34%]) completed the study (both interventions and two clamps). In comparison with the rest study, a single episode of HIT led to a 29% increase in the adrenaline (epinephrine) response (mean [SEM]) (2286.5 [343.1] vs 2953.8 [384.9] pmol/l); a significant increase in total symptom scores (Edinburgh Hypoglycaemia Symptom Scale: 24.25 [2.960 vs 27.5 [3.9]; p < 0.05), and a significant prolongation of four-choice reaction time (591.8 [22.5] vs 659.9 [39.86] ms; p < 0.01] during equivalent hypoglycaemia induced the following day. Conclusions/interpretation These findings are consistent with the hypothesis that IAH develops in people with type 1 diabetes as a habituated response and that introduction of a novel stressor can restore, at least partially, the adapted counterregulatory hormonal, symptomatic and cognitive responses to hypoglycaemia.Output Status: Forthcoming/Available Onlin

Total Acquisition in Graphs

Let G be a weighted graph in which each vertex initially has weight 1. A total acquisition move transfers all the weight from a vertex u to a neighboring vertex v, under the condition that before the move the weight on v is at least as large as the weight on u. The (total) acquisition number of G, written at(G), is the minimum size of the set of vertices with positive weight after a sequence of total acquisition moves. Among connected n-vertex graphs, at(G) is maximized by trees. The maximum is Θ(√(n lg n) for trees with diameter 4 or 5. It is⌊(n + 1)/3⌋ for trees with diameter between 6 and (2/3)(n + 1), and it is⌈(2n – 1 – D)/4⌉ for trees with diameter D when (2/3)(n + 1) ≤ D ≤ n - 1. We characterize trees with acquisition number 1, which permits testing at(G) ≤ k in time O(nk+2) on trees. If G ≠ C5, then min{at(G), at()} = 1. If G has diameter 2, then at(G) ≤ 32 ln n ln ln n; we conjecture a constant upper bound. Indeed, at(G) = 1 when G has diameter 2 and no 4-cycle, except for four graphs with acquisition number 2. Deleting one edge of an n-vertex graph cannot increase at by more than 6.84√n, but we construct an n-vertex tree with an edge whose deletion increases it by more than (1/2)√n. We also obtain multiplicative upper bounds under products

Ground heat exchanger design tool with rowwise placement of boreholes

Simulation-based design tools have been used since the late 1980s for designing ground heat exchangers (GHE) used with ground source heat pump (GSHP) systems. The ground heat exchanger simulations used in these tools rely on thermal response functions known as g-functions. Because of the significant computational burden in computing g-functions for even a single configuration, the design tools have relied on libraries of pre-computed g-functions. These g-functions were available for standard configuration shapes, such as lines, rectangles, open rectangles, L-shapes, and U-shapes. Standard shapes are often sub-optimal. For any building on a site, the available land may preclude use of a standard shape. For large GSHP systems with significantly imbalanced annual heat rejection and extraction loads, large rectangular fields may experience significant heat build-up (or heat draw-down) in the interior of the field. This paper describes a new ground heat exchanger design tool capable of automatically selecting and sizing both standard and irregular configurations. The focus of this paper is a method for creating, selecting and sizing irregular configurations where the available land area and "no-go" zones are described as irregular polygons

Quantum Computing with Continuous-Variable Clusters

Continuous-variable cluster states offer a potentially promising method of implementing a quantum computer. This paper extends and further refines theoretical foundations and protocols for experimental implementation. We give a cluster-state implementation of the cubic phase gate through photon detection, which, together with homodyne detection, facilitates universal quantum computation. In addition, we characterize the offline squeezed resources required to generate an arbitrary graph state through passive linear optics. Most significantly, we prove that there are universal states for which the offline squeezing per mode does not increase with the size of the cluster. Simple representations of continuous-variable graph states are introduced to analyze graph state transformations under measurement and the existence of universal continuous-variable resource states.Comment: 17 pages, 5 figure

Open library of g-functions for 34,321 configurations

Thermal response functions, known as g-functions, are commonly used in ground heat exchanger design tools and whole building energy simulation programs to simulate the ground heat exchanger performance. Calculation of g-functions can be quite computationally time-consuming, particularly as the number of boreholes gets large. However, once the g-function is computed, the actual simulation time can be quite short, particularly if a hybrid time-step (Cullin and Spitler 2011) approach is used. Because of this, pre-computed g-function libraries are commonly used in design tools and building simulation tools. This paper describes development of a new, publicly available library containing g-functions for 34,321 borehole field configurations; for each configuration, gfunctions are provided for 5 depths to allow interpolation between different borehole-to-height ratios. The available configurations include configurations in standard shapes: lines, rectangles, open rectangles, L-shapes, and U-shapes. It also includes new configurations: C-shapes, lopsided-U-shapes, and zoned rectangles, which are rectangular configurations with different interior and perimeter spacing of the boreholes

The Large Deficit of HMXB Emission from Luminous Infrared Galaxies: the Case of the Circumnuclear Starburst Ring in NGC 7552

Luminous infrared galaxies (LIRGs), the most extreme star-forming galaxies in the nearby (D$<$30 Mpc) Universe, show a notable X-ray emission deficiency (up to a factor of $\sim$10) compared with predictions from scaling relations of galaxy-wide high mass X-ray binary (HMXB) luminosity with star-formation rate. In the nearby ($\approx$20 Mpc) LIRG NGC 7552, the majority of the IR emission originates in a circumnuclear starburst ring, which has been resolved into several discrete knots of star formation. We present results from recent Chandra observations of NGC 7552, which reveal significant deficits in the 2-7 keV X-ray luminosities from two of the most powerful star-forming knots. We hypothesize that the expected luminous HMXB populations in these knots are either (1) obscured by very large column densities or (2) suppressed due to the knots having relatively high metallicity and/or very young ages ($\lesssim$ 5 Myr). We distinguish between these possibilities using data from recent NuSTAR observations, whose sensitivity above 10 keV is capable of uncovering heavily obscured HMXB populations, since emission at these energies is more immune to absorption effects. We find no evidence of a heavily obscured HMXB population in the central region of NGC 7552, suggesting suppressed HMXB formation. We further show that metallicity-dependent scaling relations cannot fully account for the observed deficit from the most powerful star-forming knots or the central region as a whole. Thus, we suggest that recent bursts in local star formation activity likely drive the high $L_{\rm{IR}}$ within these regions on timescales $\lesssim$ 5 Myr, shorter than the timescale required for the formation of HMXBs.Comment: Accepted for publication in ApJ (17 pages, 3 tables, 8 figures

The Role of Corticothalamic Projections (Prelimbic Cortex to Nucleus Reuniens) in Working Memory

Working memory (WM) is the ability to store information for short periods of time and is used to execute tasks WM has been understood to work via the medial prefrontal cortex (mPFC) and dorsal hippocampus (dHPC), but they do not directly project to each other The nucleus reuniens of the thalamus (Re) is a “middle man” between the mPFC and dHPC There are projections between the prelimbic cortex (PrL) and Re that may be used during WM To test the connection of the PrL to Re, a delayed nonmatch to position (DNMTP) task was performe

The metabolome as a diagnostic for maximal aerobic capacity during exercise in type 1 diabetes

Aims/hypothesis: Our aim was to characterise the in-depth metabolic response to aerobic exercise and the impact of residual pancreatic beta cell function in type 1 diabetes. We also aimed to use the metabolome to distinguish individuals with type 1 diabetes with reduced maximal aerobic capacity in exercise defined by V˙O2peak. Methods: Thirty participants with type 1 diabetes (≥3 years duration) and 30 control participants were recruited. Groups did not differ in age or sex. After quantification of peak stimulated C-peptide, participants were categorised into those with undetectable (200 pmol/l) residual beta cell function. Maximal aerobic capacity was assessed by V˙O2peak test and did not differ between control and type 1 diabetes groups. All participants completed 45 min of incline treadmill walking (60% V˙O2peak) with venous blood taken prior to exercise, immediately post exercise and after 60 min recovery. Serum was analysed using targeted metabolomics. Metabolomic data were analysed by multivariate statistics to define the metabolic phenotype of exercise in type 1 diabetes. Receiver operating characteristic (ROC) curves were used to identify circulating metabolomic markers of maximal aerobic capacity (V˙O2peak) during exercise in health and type 1 diabetes. Results: Maximal aerobic capacity (V˙O2peak) inversely correlated with HbA1c in the type 1 diabetes group (r2=0.17, p=0.024). Higher resting serum tricarboxylic acid cycle metabolites malic acid (fold change 1.4, p=0.001) and lactate (fold change 1.22, p=1.23×10−5) differentiated people with type 1 diabetes. Higher serum acylcarnitines (AC) (AC C14:1, F value=12.25, p=0.001345; AC C12, F value=11.055, p=0.0018) were unique to the metabolic response to exercise in people with type 1 diabetes. C-peptide status differentially affected metabolic responses in serum ACs during exercise (AC C18:1, leverage 0.066; squared prediction error 3.07). The malic acid/pyruvate ratio in rested serum was diagnostic for maximal aerobic capacity (V˙O2peak) in people with type 1 diabetes (ROC curve AUC 0.867 [95% CI 0.716, 0.956]). Conclusions/interpretation: The serum metabolome distinguishes high and low maximal aerobic capacity and has diagnostic potential for facilitating personalised medicine approaches to manage aerobic exercise and fitness in type 1 diabetes. Graphical Abstract

Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens

BACKGROUND: In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal influence of estrogen). This study examined the influence of phytoestrogens (estrogen-like plant compounds) on VSM, utilizing radial arm-maze methods to examine varying aspects of memory. Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined. RESULTS: Female rats receiving lifelong exposure to a high-phytoestrogen containing diet (Phyto-600) acquired the maze faster than females fed a phytoestrogen-free diet (Phyto-free); in males the opposite diet effect was identified. In a separate experiment, at 80 days-of-age, animals fed the Phyto-600 diet lifelong either remained on the Phyto-600 or were changed to the Phyto-free diet until 120 days-of-age. Following the diet change Phyto-600 females outperformed females switched to the Phyto-free diet, while in males the opposite diet effect was identified. Furthermore, males fed the Phyto-600 diet had significantly higher phytoestrogen concentrations in a number of brain regions (frontal cortex, amygdala & cerebellum); in frontal cortex, expression of CALB (a neuroprotective calcium-binding protein) decreased while COX-2 (an inducible inflammatory factor prevalent in Alzheimer's disease) increased. CONCLUSIONS: Results suggest that dietary phytoestrogens significantly sex-reversed the normal sexually dimorphic expression of VSM. Specifically, in tasks requiring the use of reference, but not working, memory, VSM was enhanced in females fed the Phyto-600 diet, whereas, in males VSM was inhibited by the same diet. These findings suggest that dietary soy derived phytoestrogens can influence learning and memory and alter the expression of proteins involved in neural protection and inflammation in rats