1,2-Epoxypropane – Addendum: evaluation of a pregnancy risk group for the BAT value

In 2012, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of 1,2-epoxypropane (propylene oxide) [75-56-9]. If the MAK value of 2 ml 1,2-epoxypropane/m3 (4.8 mg/m3) is observed, no prenatal toxic effects are to be expect ed. 1,2-epoxypropane was therefore classified in Pregnancy Risk Group C. In 2014, the biological tolerance value (BAT value) of 2500 pmol N-(2-hydroxypropyl)valine/g globin was derived in correlation to the MAK value. As a result, Pregnancy Risk Group C is likewise valid for the BAT value. No prenatal toxic effects are to be expected by compliance with the BAT value of 2500 pg N-(2-hydroxypropyl)valine/g globi

Dichloromethane – Addendum: evaluation of a pregnancy risk group for the BAT value

In 2014, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of dichloromethane [75-09-2] and set a MAK value of 50 ml dichloromethane/m3 (180 mg/m3). In humans, exposure to 50 ml/m3 of dichloromethane led to CO-Hb levels in the range of 3%, which is above the endogenous CO-Hb range of 0.4–2.6% in non-smoking pregnant women. There is no information available on the CO-Hb level at which oxygen deficiency occurs in the foetal tissues. As a result, the possibility of prenatal toxicity cannot be excluded even if the MAK value of 50 ml dichloromethane/m3 is observed. Based on thisfinding, classification in Pregnancy Risk Group B has been confirmed. In 2015, the biological tolerance value (BAT value) of 500 μg dichloromethane/l blood was derived in correlation to the MAK value. Pregnancy Risk Group B istherefore also valid forthe BAT value. The possibility of prenatal toxicity cannot be excluded even when adhering to the BAT value of 500 μg dichloromethane/l bloo

Ethylbenzene – Addendum: evaluation of a pregnancy risk group for the BAT value

In 2011, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of ethylbenzene [100-41-4]. If the MAK value of 20 ml ethylbenzene/m3 (88 mg/m3) is observed, no prenatal toxic effects are to be expected. Therefore, ethylbenzene was classified in Pregnancy Risk Group C. In 2015, the biological tolerance value (BAT value) of 250 mg mandelic acid plus phenylglyoxylic acid/g creatinine was derived in correlation to the MAK value. Pregnancy Risk Group C is therefore similarly valid for the BAT value. In adherence with the BAT value of 250 mg mandelic acid plus phenylglyoxylic acid/g creatinine, no prenatal toxic effects are to be expected

2-Propanol – Addendum: evaluation of a pregnancy risk group for the BAT value

In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated and confirmed the maximum workplace concentration (MAK value) of 2-propanol [67-63-0]. If the MAK value of 200 ml 2-propanol/m3 (500 mg/m3) is observed, no prenatal toxic effects are to be expected. Therefore, Pregnancy Risk Group C was likewise confirmed. In 2010, biological tolerance values (BAT values) of 25 mg acetone/l blood and 25 mg acetone/l urine were derived in correlation to the MAK value. Pregnancy Risk Group C is therefore similarly valid for the BAT value. In adherence with the BAT values of 25 mg acetone/l blood and 25 mg acetone/l urine, no prenatal toxic effects are to be expecte

Isopropylbenzene – Addendum: evaluation of a pregnancy risk group for the BAT value

In 2012, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of isopropylbenzene (cumene) [98-82-8]. If the MAK value of 10 ml iso-propylbenzene/m3 (50 mg/m3) is observed, no prenatal toxic effects are to be expected. Therefore, Pregnancy Risk Group C was confirmed. In 2013, the biological tolerance value (BAT value) of 10 mg 2-phenyl-2-propanol (after hydrolysis)/g creatinine was derived in correlation to the MAK value. Pregnancy Risk Group C is also similarly valid for the BAT value. In adherence with the BAT value of 10 mg 2-phenyl-2-propanol (after hydrolysis)/g creatinine, no prenatal toxic effects are to be expected

1,2-Epoxypropan – Addendum: Evaluierung der Schwangerschaftsgruppe zum BAT-Wert

In 2012, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of 1,2-epoxypropane (propylene oxide) [75-56-9]. If the MAK value of 2 ml 1,2-epoxypropane/m3 (4.8 mg/m3) is observed, no prenatal toxic effects are to be expect ed. 1,2-epoxypropane was therefore classified in Pregnancy Risk Group C. In 2014, the biological tolerance value (BAT value) of 2500 pmol N-(2-hydroxypropyl)valine/g globin was derived in correlation to the MAK value. As a result, Pregnancy Risk Group C is likewise valid for the BAT value. No prenatal toxic effects are to be expected by compliance with the BAT value of 2500 pg N-(2-hydroxypropyl)valine/g globi

2-Propanol – Addendum: Evaluierung der Schwangerschaftsgruppe zum BAT-Wert

In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated and confirmed the maximum workplace concentration (MAK value) of 2-propanol [67-63-0]. If the MAK value of 200 ml 2-propanol/m3 (500 mg/m3) is observed, no prenatal toxic effects are to be expected. Therefore, Pregnancy Risk Group C was likewise confirmed. In 2010, biological tolerance values (BAT values) of 25 mg acetone/l blood and 25 mg acetone/l urine were derived in correlation to the MAK value. Pregnancy Risk Group C is therefore similarly valid for the BAT value. In adherence with the BAT values of 25 mg acetone/l blood and 25 mg acetone/l urine, no prenatal toxic effects are to be expected

Ethylbenzol – Addendum: Evaluierung der Schwangerschaftsgruppe zum BAT-Wert

In 2011, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of ethylbenzene [100-41-4]. If the MAK value of 20 ml ethylbenzene/m3 (88 mg/m3) is observed, no prenatal toxic effects are to be expected. Therefore, ethylbenzene was classified in Pregnancy Risk Group C. In 2015, the biological tolerance value (BAT value) of 250 mg mandelic acid plus phenylglyoxylic acid/g creatinine was derived in correlation to the MAK value. Pregnancy Risk Group C is therefore similarly valid for the BAT value. In adherence with the BAT value of 250 mg mandelic acid plus phenylglyoxylic acid/g creatinine, no prenatal toxic effects are to be expecte