Trade relations between Central Asia and Kashmir Himalayas during the Dogra period (1846-1947)

Notwithstanding the great mountain barriers of Hindu Kush, Karakoram, Kuen Lun and Western Himalayas, there existed overland trade links between India and Central Asia since ancient times which in turn exerted strong influence on the socio-economic developments in both the regions. The caravan traders acted as the medium of exchange of art, culture, ideas and technology thereby assisting in the process of urbanisation. So much so, many areas along the trade routes became famous for their spec..

Trade relations between Central Asia and Kashmir Himalayas during the Dogra period (1846-1947)

Notwithstanding the great mountain barriers of Hindu Kush, Karakoram, Kuen Lun and Western Himalayas, there existed overland trade links between India and Central Asia since ancient times which in turn exerted strong influence on the socio-economic developments in both the regions. The caravan traders acted as the medium of exchange of art, culture, ideas and technology thereby assisting in the process of urbanisation. So much so, many areas along the trade routes became famous for their spec..

QSAR model to develop newer generation GSK-3β inhibitors targeting Alzheimer

In the year 2022 most of the patients affected by the disease was around 65 year age. Among total number of patients, 73% were near 75 year or older age. It was also stated that maximum numbers of patients were women. Black Americans were more affected by Alzheimer than white Americans. GSK-3β was also linked with hyperphosphorylation of tau protein followed by the increasing number of amyloid-beta plaques and other inflammatory responses followed by activation of microglial cells to develop neurotoxic inflammatory factors along with reducing the concentration of acetylcholine; these factors cumulatively create Alzheimer disease. GSK-3β modulated the inflammatory stress related to endoplasmic reticulum and mitochondrial abnormalities. But all the molecules those were used in the treatment not so much effective to fully cure the patient. So, to break this jinx to develop of newer generation anti Alzheimer drug molecules, computational approaches played an essential role. The most effective QSAR model was pIC50 = -5.47052 +2.60572 IC1 +1.64642 GATS2e +2.088 mindssC -0.01441 ATSC7s -13.5191 AVP-0 +0.16712 minssNH -0.15369 minaaN +0.01777 VR2_Dt +1.52684 MATS8s +0.04725 nAtomP with all necessary acceptance criteria Q^2: 0.60111, r^2: 0.65711, |r0^2-r'0^2|: 0.07866, k: 0.99121 [(r^2-r0^2)/r^2] 0.00543 or k': 0.92437 [(r^2-r'0^2)/r^2] 0.12513. It can be easily concluded that if in near future we want to develop a small molecule effective as GSK-3β inhibitor active against Alzheimer disease, this QSAR model will work as a boon for the mankind

Asian American Perspectives on Immigration Policy

Despite the rapid growth in both documented and undocumented Asian Americans, their attitudes toward immigration policy are not well understood. Drawing on data from the 2016 National Asian American Survey, this article examines both interracial and intra-Asian differences in views toward immigration. Relative to other racial groups, Asians are as likely to support legal migration, but less likely to support undocumented migration. We document significant diversity among Asians. As labor migrants, Filipinos support a congressional increase in annual work visas. As economic migrants, Chinese and Indians support an increase in annual family visas. As refugees, Vietnamese are least supportive of pro-immigration policy. These findings contribute to research on policy support by systematically including Asian Americans in this debate and by revealing their diverse policy perspectives

The academy for future science faculty:randomized controlled trial of theory-driven coaching to shape development and diversity of early-career scientists

Background: Approaches to training biomedical scientists have created a talented research community. However, they have failed to create a professional workforce that includes many racial and ethnic minorities and women in proportion to their representation in the population or in PhD training. This is particularly true at the faculty level. Explanations for the absence of diversity in faculty ranks can be found in social science theories that reveal processes by which individuals develop identities, experiences, and skills required to be seen as legitimate within the profession. Methods/Design: Using the social science theories of Communities of Practice, Social Cognitive Career Theory, identity formation, and cultural capital, we have developed and are testing a novel coaching-based model to address some of the limitations of previous diversity approaches. This coaching intervention (The Academy for Future Science Faculty) includes annual in-person meetings of students and trained faculty Career Coaches, along with ongoing virtual coaching, group meetings and communication. The model is being tested as a randomized controlled trial with two cohorts of biomedical PhD students from across the U.S., one recruited at the start of their PhDs and one nearing completion. Stratification into the experimental and control groups, and to coaching groups within the experimental arms, achieved equal numbers of students by race, ethnicity and gender to the extent possible. A fundamental design element of the Academy is to teach and make visible the social science principles which highly influence scientific advancement, as well as acknowledging the extra challenges faced by underrepresented groups working to be seen as legitimate within the scientific communities. Discussion: The strategy being tested is based upon a novel application of the well-established principles of deploying highly skilled coaches, selected and trained for their ability to develop talents of others. This coaching model is intended to be a complement, rather than a substitute, for traditional mentoring in biomedical research training, and is being tested as such

Beyond the numbers: Institutional influences on experiences with diversity on elite college campuses

In this article we bring together the burgeoning qualitative literature on the socializing influence of residential colleges, the survey-based literature on campus racial climate, and the literature on diversity work in organizations to analyze how two elite universities\u27 approaches to diversity shape students\u27 experiences with and feelings about diversity. We employ 77 in-depth interviews with undergraduates at two elite universities. While the universities appear comparable on measures of student demographics and overall diversity infrastructure, they take different approaches. These varying approaches lead to important differences in student perspectives. At the university that takes a power analysis and minority support approach, students who participate in minority-oriented activities develop a critical race theory perspective, while their white and nonparticipating minority peers frequently feel alienated from that programming. At the university that takes an integration and celebration approach, most students embrace a cosmopolitan perspective, celebrating diversity while paying less attention to power and resource differences between racial groups. The findings suggest that higher education institutions can influence the race frames of students as well as their approaches to multiculturalism, with implications for their views on a variety of important diversity-related issues on campus and beyond

Interactions among motility, fertilizing ability, and testosterone binding on spermatozoa of bonnet monkey (Macaca radiata)

Fresh ejaculates of bonnet monkeys were separated into fractions rich with highly motile and sluggishly motile spermatozoa. The motility, ability to fertilize zona-free hamster eggs, and distribution of testosterone-binding sites on spermatozoa were assessed to determine the relation between these sperm functions. Two parameters of objective assessment of motility—velocity and degree of flagellar bending—were significantly correlated with the ability to form pronuclei in zona-free hamster eggs. Only spermatozoa with good motility could form pronuclei, which might be important for assessment of the fertilizing ability. The motility was directly related to the distribution of testosterone-binding sites; the fraction having mostly motile spermatozoa was distributed over the sperm surface. The technique is simple and may be used to evaluate semen of nonhuman primates