Genetic Determinants For Cancer Risks With Racial Differences And Asthma

Over the past decade, many studies have found disproportionally higher prostate cancer among men of African ancestry, and testicular cancer incidences among men of European ancestry, compared with men from other ethnicity/race groups. However, genetic determinants that could potentially explain this observation are unclear. This study collected single nucleotide polymorphisms (SNPs) related to the two cancer types and compared the frequencies of each risk allele of SNPs among men of African or European ancestry from several genetic databases. When comparing the frequencies of risk alleles that are associated with prostate and testicular cancers, significant differences were found between those of African descendants and European descendants. As the second part of this thesis, we investigated the roles of genetic in the reversal relationship observed between asthma and all cancer risks. Single Nucleotide Polymorphisms that were reported to be associated with asthma were collected and identified first and the cancer risks related to each variant were reviewed in the hope to provide genetic basis for future pathway analysis

Connecting shear localization with the long-range correlated polarized stress fields in granular materials

One long-lasting puzzle in amorphous solids is shear localization, where local plastic deformation involves cooperative particle rearrangements in small regions of a few inter-particle distances, self-organizing into shear bands and eventually leading to the material failure. Understanding the connection between the structure and dynamics of amorphous solids is essential in physics, material sciences, geotechnical and civil engineering, and geophysics. Here we show a deep connection between shear localization and the intrinsic structures of internal stresses in an isotropically jammed granular material subject to shear. Specifically, we find strong (anti)correlations between the micro shear bands and two polarized stress fields along two directions of maximal shear. By exploring the tensorial characteristics and the rotational symmetry of force network, we reveal that such profound connection is a result of symmetry breaking by shear. Finally, we provide the solid experimental evidence of long-range correlated inherent shear stress in an isotropically jammed granular system.Comment: 23 pages, 9 figure

Distinct elastic properties and their origins in glasses and gels

Glasses and gels, widely encountered amorphous solids with diverse industrial and everyday applications, share intriguing similarities such as rigidity without crystalline order and dynamic slowing down during aging. However, the underlying differences between these two fascinating materials have remained elusive. Here we uncover distinct elastic properties concerning observation and aging times in glasses and gels, while delving into the underlying mechanisms. In glasses, we observe a gradual decrease in the shear modulus, while the bulk modulus remains constant throughout the observation time. In contrast, gels exhibit a decrease in both the shear and bulk moduli over the observation time. Additionally, during aging, glasses exhibit a steady trend of stiffening, while gels demonstrate initial stiffening followed by softening. By unravelling the intricate relationship between structure, dynamics, and elasticity, we attribute these differences to mechanisms that minimize free energy: structural ordering in glasses and interface reduction in gels. Our work not only uncovers the distinct behaviors of glasses and gels but also sheds light on the origin and evolution of elasticity in non-equilibrium disordered solids, offering significant implications for the application and design of amorphous materials.Comment: 15 pages, 5 figures, 5 Supplementary Figure

Experimental evidence of detailed balance in granular systems

The principle of detailed balance (DB) states that every kinetic transition in a system with many micro-states, $\mu$, is balanced, on average, with the opposite transition, $\mu_i\leftrightharpoons\mu_j$. Since its introduction by Boltzmann, this principle has been used by luminaries, such as Einstein, Eddington, Kramers, Pauli, Ehrenfest, Dirac, Onsager, and many others to derive significant results that underpin much of our scientific understanding. The current belief is that DB is satisfied only in equilibrium systems, while non-equilibrium steady states can only be balanced by cycles, such as $A\to B\to C\to A$. We show here experimentally that DB can exist and is commonly and robustly satisfied in a family of quasi-statically cyclically sheared granular systems. We further study the approach to DB as a function of system size and time. Given the significant impact that this principle has had on equilibrium systems, we believe that this discovery paves the way for better models of the dynamics of non-equilibrium systems.Comment: 5 pages, 4 figure

West Hartford-Bloomfield Health District Community Needs Assessment: A Mixed Methods Study Identifying COVID-19 Knowledge, Perceptions, and Health Disparities

Background: The West Hartford-Bloomfield Health District (WHBHD) is a regional health department serving the towns of West Hartford and Bloomfield in Connecticut. From February to April of 2020, elderly and Black residents accounted for 59% and 38% of COVID-19 related deaths, respectively. Since the district has not assessed community health needs previously and is interested in becoming accredited, a community needs assessment will serve as the first step in implementing effective and timely interventions to address needs, disparities, and misperceptions about the pandemic. Methods: A comprehensive survey was adapted from existing NIH COVID-19 research instruments. 779 responses were collected on the topics of community health and COVID-19 knowledge, practices and perceptions. Five semi-structured key informant interviews were conducted with faith-based organizations and local government leaders to corroborate findings from the survey. Quantitative analyses were performed via SAS and R, and qualitative data was summarized. Results: Demographic distributions significantly differed between West Hartford and Bloomfield in age, income, race, marital status and household size. While there were differences in community health problems, social/environmental problems, and health care barriers, both towns shared individual health problems and perceived certain populations as most underserved. Both towns have adequate COVID-19 knowledge regarding symptoms and transmissions, low perceived risk of infection, and positive attitude towards preventative actions and measures. There were significant differences in COVID-19 testing accessibility between towns (p = 0.002), with nearly double the proportion of West Hartford residents reporting difficulty accessing testing. COVID-19 vaccination status is also different between towns, with both reporting lack of available vaccines as the primary reason preventing or delaying vaccination. Conclusions: The mixed methods approach to conducting this community needs assessment has provided consequential preliminary findings that will be useful in refining the health district’s current and future responses to COVID-19 and other public health issues.https://elischolar.library.yale.edu/ysph_pbchrr/1055/thumbnail.jp

A review on shear jamming

Jamming is a ubiquitous phenomenon that appears in many soft matter systems, including granular materials, foams, colloidal suspensions, emulsions, polymers, and cells -- when jamming occurs, the system undergoes a transition from flow-like to solid-like states. Conventionally, the jamming transition occurs when the system reaches a threshold jamming density under isotropic compression, but recent studies reveal that jamming can also be induced by shear. Shear jamming has attracted much interest in the context of non-equilibrium phase transitions, mechanics and rheology of amorphous materials. Here we review the phenomenology of shear jamming and its related physics. We first describe basic observations obtained in experiments and simulations, and results from theories. Shear jamming is then demonstrated as a "bridge" that connects the rheology of athermal soft spheres and thermal hard spheres. Based on a generalized jamming phase diagram, a universal description is provided for shear jamming in frictionless and frictional systems. We further review the isostaticity and criticality of the shear jamming transition, and the elasticity of shear jammed solids. The broader relevance of shear jamming is discussed, including its relation to other phenomena such as shear hardening, dilatancy, fragility, and discrete shear thickening.Comment: 19 pages, 9 figure

HandBooster: Boosting 3D Hand-Mesh Reconstruction by Conditional Synthesis and Sampling of Hand-Object Interactions

Reconstructing 3D hand mesh robustly from a single image is very challenging, due to the lack of diversity in existing real-world datasets. While data synthesis helps relieve the issue, the syn-to-real gap still hinders its usage. In this work, we present HandBooster, a new approach to uplift the data diversity and boost the 3D hand-mesh reconstruction performance by training a conditional generative space on hand-object interactions and purposely sampling the space to synthesize effective data samples. First, we construct versatile content-aware conditions to guide a diffusion model to produce realistic images with diverse hand appearances, poses, views, and backgrounds; favorably, accurate 3D annotations are obtained for free. Then, we design a novel condition creator based on our similarity-aware distribution sampling strategies to deliberately find novel and realistic interaction poses that are distinctive from the training set. Equipped with our method, several baselines can be significantly improved beyond the SOTA on the HO3D and DexYCB benchmarks. Our code will be released on https://github.com/hxwork/HandBooster_Pytorch

Gender-Specific and U-Shaped Relationship Between Serum Uric Acid and All-Cause Mortality Among Chinese Older Adults: A National Population-Based Longitudinal Study

Objectives: This study aimed to prospectively investigate gender-specific relationship between hyperuricemia and all-cause mortality among Chinese older adults.Methods: The study was based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2008–2018, a prospective nationwide cohort of older adults in China. Multivariate Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for all-cause mortality. Restricted cubic splines (RCS) were conducted to explore the dose-response relationship between SUA levels and all-cause mortality.Results: For older women, compared to the participants in the third quartile of SUA level, those in the highest quartile of SUA was associated with significantly higher risk of all-cause mortality in the fully adjusted model (HR: 1.41, 95% CI: 1.03–1.92). No significant associations between SUA levels and all-cause mortality were observed in older men. The present study further found a U-shaped non-linear relationship between SUA levels and all-cause mortality in both sexes of older population (P for non-linear <0.05).Conclusions: This study provided prospective epidemiological evidence for the predictive role of SUA on all-cause mortality among the Chinese aging population over 10 years of follow-up, while revealing considerable gender-related differences