143 research outputs found
A novel signature based on microvascular invasion predicts the recurrence of HCC.
BACKGROUND AND OBJECTIVES: In hepatocellular carcinoma (HCC) patients, microvascular invasion (MVI) is associated with worse outcomes regardless of treatment. No single reliable preoperative factor exists to predict MVI. The aim of the work described here was to develop a new MVI- based mRNA biomarker to differentiate between high and low risk patients.
METHODS: Using The Cancer Genome Atlas (TCGA) database, we collected data from 315 HCC patients, including mRNA expression and complete clinical data. We generated a seven-mRNA signature to predict patient outcomes. The mRNA signature was validated using the GSE36376 cohort. Finally, we tested the formula in our own 53 HCC patients using qPCR for the seven mRNAs and analyzing the computed tomography (CT) features.
RESULTS: This seven-mRNA signature significantly correlated with length of recurrence-free survival (RFS) and overall survival (OS) for both the training and validation groups. RFS and OS were briefer in high risk versus low risk patients. A Kaplan-Meier analysis also indicated that survival time was significantly shortened in the high risk group versus the low risk group. Time-dependent receiver operating characteristic analysis demonstrated good predictive performance for the seven-mRNA signature. The mRNA signature also acts as an independent factor according to a Multivariate analysis. Our results are consistent with the seven-mRNA formula risk score.
CONCLUSION: Our research showed a novel seven-mRNA biomarker based on MVI predicting RFS and OS in HCC patients. This mRNA signature can stratify patients into subgroups based on their risk of recurrence to help guide individualized treatment and precision management in HCC
Laparoscopic Transient Uterine Artery Occlusion and Myomectomy for Symptomatic Uterine Myoma as an Alternative to Hysterectomy
Objective: To compare the clinical outcomes of laparoscopic transient uterine artery ligation plus myomectomy (LTUAL) to simple laparoscopic myomectomy (LM) for symptomatic myomas
Combining linear-scaling quantum transport and machine-learning molecular dynamics to study thermal and electronic transports in complex materials
We propose an efficient approach for simultaneous prediction of thermal and
electronic transport properties in complex materials. Firstly, a highly
efficient machine-learned neuroevolution potential is trained using reference
data from quantum-mechanical density-functional theory calculations. This
trained potential is then applied in large-scale molecular dynamics
simulations, enabling the generation of realistic structures and accurate
characterization of thermal transport properties. In addition, molecular
dynamics simulations of atoms and linear-scaling quantum transport calculations
of electrons are coupled to account for the electron-phonon scattering and
other disorders that affect the charge carriers governing the electronic
transport properties. We demonstrate the usefulness of this unified approach by
studying thermoelectric transport properties of a graphene antidot lattice.Comment: 8 pages, 4 figure
A minimal Tersoff potential for diamond silicon with improved descriptions of elastic and phonon transport properties
Silicon is an important material and many empirical interatomic potentials
have been developed for atomistic simulations of it. Among them, the Tersoff
potential and its variants are the most popular ones. However, all the existing
Tersoff-like potentials fail to reproduce the experimentally measured thermal
conductivity of diamond silicon. Here we propose a modified Tersoff potential
and develop an efficient open source code called GPUGA (graphics processing
units genetic algorithm) based on the genetic algorithm and use it to fit the
potential parameters against energy, virial and force data from quantum density
functional theory calculations. This potential, which is implemented in the
efficient open source GPUMD (graphics processing units molecular dynamics)
code, gives significantly improved descriptions of the thermal conductivity and
phonon dispersion of diamond silicon as compared to previous Tersoff potentials
and at the same time well reproduces the elastic constants. Furthermore, we
find that quantum effects on the thermal conductivity of diamond silicon at
room temperature are non-negligible but small: using classical statistics
underestimates the thermal conductivity by about 10\% as compared to using
quantum statistics.Comment: 9 pages, 6 figure
Scalable Scheduling for Industrial Time-Sensitive Networking: A Hyper-flow Graph Based Scheme
Industrial Time-Sensitive Networking (TSN) provides deterministic mechanisms
for real-time and reliable flow transmission. Increasing attention has been
paid to efficient scheduling for time-sensitive flows with stringent
requirements such as ultra-low latency and jitter. In TSN, the fine-grained
traffic shaping protocol, cyclic queuing and forwarding (CQF), eliminates
uncertain delay and frame loss by cyclic traffic forwarding and queuing.
However, it inevitably causes high scheduling complexity. Moreover, complexity
is quite sensitive to flow attributes and network scale. The problem stems in
part from the lack of an attribute mining mechanism in existing frame-based
scheduling. For time-critical industrial networks with large-scale complex
flows, a so-called hyper-flow graph based scheduling scheme is proposed to
improve the scheduling scalability in terms of schedulability, scheduling
efficiency and latency & jitter. The hyper-flow graph is built by aggregating
similar flow sets as hyper-flow nodes and designing a hierarchical scheduling
framework. The flow attribute-sensitive scheduling information is embedded into
the condensed maximal cliques, and reverse maps them precisely to congestion
flow portions for re-scheduling. Its parallel scheduling reduces network scale
induced complexity. Further, this scheme is designed in its entirety as a
comprehensive scheduling algorithm GH^2. It improves the three criteria of
scalability along a Pareto front. Extensive simulation studies demonstrate its
superiority. Notably, GH^2 is verified its scheduling stability with a runtime
of less than 100 ms for 1000 flows and near 1/430 of the SOTA FITS method for
2000 flows
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