758 research outputs found

    Nova praga exĂłtica no ecossistema florestal.

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    O país estå convivendo desde de junho de 2003 com mais uma séria praga de florestas de eucalipto, o psilídeode- concha, Glycaspis brimblecombei (Hemiptera: Psyllidae). Este inseto, de tamanho reduzido, é semelhante a uma cigarrinha que suga a seiva das folhas novas das årvores. A praga tem provocado danos às florestas de eucaliptos, e atualmente se encontra distribuída em mais de 140 municípios do Estado de São Paulo, em pelo menos 20 municípios de Minas Gerais, um de Goiås, dois de Mato Grosso do Sul e seis do Paranå.bitstream/CNPMA/5837/1/comunicado_18.pd

    Towards biological control strategies for the bronze bug, Thaumastocoris peregrinus, on eucalyptus plantations in South America.

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    Edição dos abstracts do 24Âș IUFRO World Congress, 2014, Salt Lake City. Sustaining forests, sustaining people: the role of research

    Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53

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    The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers. Here, we identify different classes of small molecules that bind to this crevice and determine their binding modes by X-ray crystallography. These structures reveal two major conformational states of the pocket and a cryptic, transiently open hydrophobic subpocket that is modulated by Cys220. In one instance, specifically targeting this transient protein state by a pyrrole moiety resulted in a 40-fold increase in binding affinity. Molecular dynamics simulations showed that both open and closed states of this subsite were populated at comparable frequencies along the trajectories. Our data extend the framework for the design of high-affinity Y220C mutant binders for use in personalized anticancer therapy and, more generally, highlight the importance of implementing protein dynamics and hydration patterns in the drug-discovery process

    Improving mass rearing techniques for Cleruchoides noackae (Hymenoptera: Mymaridae).

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    Edição dos abstracts do 24Âș IUFRO World Congress, 2014, Salt Lake City. Sustaining forests, sustaining people: the role of research

    <sup>14</sup>C AMS at SUERC: improving QA data from the 5 MV tandem AMS and 250 kV SSAMS

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    In 2003, a National Electrostatics Corporation (NEC) 5MV tandem accelerator mass spectrometer was installed at SUERC, providing the radiocarbon laboratory with 14C measurements to 4–5‰ repeatability. In 2007, a 250kV single-stage accelerator mass spectrometer (SSAMS) was added to provide additional 14C capability and is now the preferred system for 14C analysis. Changes to the technology and to our operations are evident in our copious quality assurance data: typically, we now use the 134-position MC-SNICS source, which is filled to capacity. Measurement of standards shows that spectrometer running without the complication of on-line ή13C evaluation is a good operational compromise. Currently, 3‰ 14C/13C measurements are routinely achieved for samples up to nearly 3 half-lives old by consistent sample preparation and an automated data acquisition algorithm with sample random access for measurement repeats. Background and known-age standard data are presented for the period 2003–2008 for the 5MV system and 2007–2008 for the SSAMS, to demonstrate the improvements in data quality
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