Non-resonant new physics search at the LHC for the b → cτν anomalies

Motivated by the →$\overline{}$ anomalies, we study non-resonant searches for new physics at the large hadron collider (LHC) by considering final states with an energetic and hadronically decaying τ lepton, a b-jet and large missing transverse momentum (→ℎ$\overline{}$+$^{miss}$$_{T}$). Such searches can be useful to probe new physics contributions to →$\overline{}$. They are analyzed not only within the dimension-six effective field theory (EFT) but also in explicit leptoquark (LQ) models with the LQ non-decoupled. The former is realized by taking a limit of large LQ mass in the latter. It is clarified that the LHC sensitivity is sensitive to the LQ mass for (1) TeV even in the search of →ℎ$\overline{}$+$^{miss}$$_{T}$. Although the LQ models provide a weaker sensitivity than the EFT limit, it is found that the non-resonant search of →ℎ$\overline{}$+$^{miss}$$_{T}$ can improve the sensitivity by ≈ 40% versus a conventional mono-τ search (→ℎ$\overline{}$+$^{miss}$$_{T}$) in the whole LQ mass region. Consequently, it is expected that most of the parameter regions suggested by the →$\overline{}$⎯ anomalies can be probed at the HL-LHC. Also, it is shown that R$_{2}$ LQ scenario is accessible entirely once the LHC Run 2 data are analyzed. In addition, we discuss a charge selection of τh to further suppress the standard-model background, and investigate the angular correlations among b, τ and the missing transverse momentum to discriminate the LQ scenarios

Investigation of the tracheal suctioning-related microbialcolonization in home care patients with tracheotomy

気管内吸引を必要とする在宅療養患者に対し,安全で経済的な感染管理方法を検討するため,在宅ケアにおける気管内吸引の実態と,吸引関連物品の細菌学的調査を実施した。対象は気管切開がされ,医療依存度の高い患者3名であり,気管内吸引は全て患者の妻が行っていた。吸引後のカテーテルは外側をアルコール綿で清拭し,内腔を洗浄水で洗浄していた。カテーテルは,0.05%グルコン酸クロルヘキシジンに浸漬あるいは,清潔な乾燥容器に保管されていた。カテーテルの交換時期は,1.5日から7日とばらつきがあった。カテーテル,洗浄水,浸潰液等の試料を,一般細菌,黄色ブドウ球菌,大腸菌群の寒天培地で培養したところ,各試料から一般細菌,黄色ブドウ球菌,大腸菌群が検出されたが,カテーテルの保管方法の違いによる細菌汚染に差は認められなかった｡また,気管切開部ガーゼからは,一般細菌,黄色ブドウ球菌,大腸菌群が検出された｡これらより,気管内吸引カテーテルおよび,洗浄水や浸溝用消毒液の清潔管理の必要性が示唆された｡Microbial colonization related to tracheal toilet was investigated in three home care patients who had tracheotomy with or without mechanical ventilation. We focused on the manipulation of suctioning tube to develop a effective and low-cost guidline for infection control. Tracheal suctioning was doned by wife in all the patients. Catheters used for suctioning was generally wiped with alcohol, washed in deionized or boiled water, and stored in alcohol-wiped container or immersed in 0.05% gluconate chlorhexizine. Catheter was changed into new one every 1.5 to 7 days. Samples were obtained from catheter, water used for washing, container as well as patients and their caregivers, and cultured on agar culture plate for Staphylococcus aureus, or Escherichia coli. Colonization of gauze around tracheotomy and water used for washing was detected in two patinets. E. coli and S. aureus were common organism colonizing gauze around tracheotomy. Therefore, it was suggested that the manipulation of the tracheal suctioning in home care influence on microbial colonization

Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of FcγRllB-deficient Mice

Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV