Integrated approach to the modification of the shipping register in Macao

The dissertation is a study on the modification of the shipping register in Macao. It begins by revealing the facts about the current registration of ships in the territory and ends with proposing a modified shipping register which is considered acceptable to all parties involved and some recommendations for its further development. During the process, a brief look is taken at the historical background of the creation of the Macao Ship’s Register (MSR), the cause of its inoperability and the reality of the registration of ships in the territory - the registration of property of ships instead of registration in a real sense. The other issue to be examined are the needs for the modification of this irregular situation of the registration of ships in Macao. They are primarily the needs of the Republic of Portugal (Portugal) and the People’s Republic of China (PRC) for the smooth transference of administration of Macao from the former to the latter according to the Joint Declaration on the Question of Macao (Joint Declaration). As the necessity for the modification of the MSR to make it operable is recognized, a proposed modified shipping register is thus presented. In the proposal, all possible conflicts of interests with Portugal and the PRC are prevented with no cost to the interests of the territory. Otherwise, the register would either fail in concretization or become meaningless to the territory. Consequently, stringent requirements for ownership of ships and manning requirements with conditional flexibility are included in the proposed register. IV In the concluding chapter, conclusions and recommendations are made. The former concentrates on the benefits that the proposed modified shipping register would bring, while the latter is on the eventual efforts of the Capitania dos Ports de Macao (CPM, Harbor Master’s Office of Macao) to help smooth the operations and future development of the register

Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein

Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible p53 aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia and the presence of reactive oxygen species (ROS). The angiogenic pathways involving p53 mainly occur in nucleus or cytoplasm, with one exception that occurs in mitochondria. Considering the high mitochondrial density in brain and endothelial cells, we proposed that the cyclophilin D (CypD)-dependent vascular endothelial cell (VECs) necrosis pathway occurring in the mitochondria is one of the major factors that affects angiogenesis. Hence, targeting p53 aggregation, a key intermediate in the pathway, could be an alternative therapeutic target for post-stroke management